{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T09:14:27Z","timestamp":1793006067680,"version":"4.5.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Infectious mononucleosis (IM) is a syndrome caused by the Epstein-Barr virus. IM typically presents with fever, pharyngitis and lymphadenopathy. Rarely, it can cause acute appendicitis. We report the case of a 19-year-old female presenting with a chief complaint of colicky, non-radiating abdominal pain for 2\u00a0days. Abdominal examination revealed rebound tenderness in right iliac fossa tenderness and splenomegaly. The diagnosis of acute appendicitis was confirmed by computed tomography. She underwent laparoscopic appendectomy and mesenteric lymph node biopsy. She was later diagnosed with IM based on laboratory findings and histopathology results. She received a course of intravenous acyclovir and was discharged. This shows that IM may present with acute appendicitis as the initial presentation and may not be accompanied by any other significant symptoms of IM.<\/jats:p>","DOI":"10.1093\/jscr\/rjab039","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T12:10:23Z","timestamp":1611922223000},"source":"Crossref","is-referenced-by-count":5,"title":["An insidious case of infectious mononucleosis presenting with acute appendicitis diagnosed postoperatively: a case report"],"prefix":"10.1093","volume":"2021","author":[{"given":"Faisal A","family":"AlMudaiheem","sequence":"first","affiliation":[{"name":"Department of General Surgery, Ministry of the National Guard-Health Affairs, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Alhabdan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ministry of the National Guard-Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S","family":"Alhalafi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Alshieban","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City-National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"2021031109213479500_ref1","first-page":"211","article-title":"Infectious mononucleosis","volume":"390","author":"Dunmire","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"2021031109213479500_ref2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0011-5029(74)80012-X","article-title":"Infectious mononucleosis","volume":"20","author":"Chervenick","year":"1974","journal-title":"Dis Mon"},{"key":"2021031109213479500_ref3","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.jpedsurg.2007.02.030","article-title":"Infectious mononucleosis manifested as a cecal mass","volume":"42","author":"Keramidas","year":"2007","journal-title":"J Pediatr Surg"},{"key":"2021031109213479500_ref4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/clinids\/12.2.297","article-title":"Acute appendicitis complicating infectious mononucleosis: case report and review","volume":"12","author":"Lopez-Navidad","year":"1990","journal-title":"Rev Infect Dis"},{"key":"2021031109213479500_ref5","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/bmj.38940.664363.AE","article-title":"Acute appendicitis","volume":"333","author":"Humes","year":"2006","journal-title":"BMJ"},{"key":"2021031109213479500_ref6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/00365540410020271","article-title":"Cytomegalovirus appendicitis following acute Epstein-Barr virus infection in an immunocompetent patient","volume":"36","author":"Kanafani","year":"2004","journal-title":"Scand J Infect Dis"},{"key":"2021031109213479500_ref7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13256-016-0859-x","article-title":"Acute cholestatic hepatitis induced by Epstein-Barr virus infection in an adult: a case report","volume":"10","author":"Khoo","year":"2016","journal-title":"J Med Case Reports"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/3\/rjab039\/36512808\/rjab039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/3\/rjab039\/36512808\/rjab039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T11:36:57Z","timestamp":1615462617000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjab039\/6161808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjab039","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3]]},"published":{"date-parts":[[2021,3,1]]},"article-number":"rjab039"}}