{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:34Z","timestamp":1753877194643,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Anal canal neuroendocrine carcinoma (NEC) with pagetoid spread (PS) is a rare disease, and its treatment strategy remains unclear. The prognosis of anal canal NEC with PS is poor. Resection margin status is very important for anorectal carcinoma because it affects survival. When accompanied by PS, the defect of the resulting perineal wound following radical surgical intervention may be necessarily enlarged to ensure the appropriate margin status. This case report discusses the treatment of a patient with advanced anal canal NEC with PS, inguinal lymph node metastasis and sphincter infiltration in which total pelvic exenteration with plastic surgery was successfully performed. The plastic surgery incorporated a gracilis muscle flap that was useful for the reconstruction of the enlarged perineal defect.<\/jats:p>","DOI":"10.1093\/jscr\/rjab111","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T19:08:40Z","timestamp":1619896120000},"source":"Crossref","is-referenced-by-count":2,"title":["Radical surgery for anal canal neuroendocrine carcinoma with pagetoid spread: a case report"],"prefix":"10.1093","volume":"2021","author":[{"given":"Sotaro","family":"Fukuhara","sequence":"first","affiliation":[{"name":"Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, 7-33, Motomachi, Naka-ku, Hiroshima 730-8518, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Yoshimitsu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, 7-33, Motomachi, Naka-ku, Hiroshima 730-8518, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, 7-33, Motomachi, Naka-ku, Hiroshima 730-8518, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Oshita","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, 7-33, Motomachi, Naka-ku, Hiroshima 730-8518, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Bekku","sequence":"additional","affiliation":[{"name":"Department of Urology, Hiroshima City Hiroshima Citizens Hospital, 7-33, Motomachi, Naka-ku, Hiroshima 730-8518 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hiroshima City Hiroshima Citizens Hospital, 7-33, Motomachi, Naka-ku, Hiroshima 730-8518, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Toi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hiroshima City Hiroshima Citizens Hospital, 7-33, Motomachi, Naka-ku, Hiroshima 730-8518, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ichimura","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hiroshima City Hiroshima Citizens Hospital, 7-33, Motomachi, Naka-ku, Hiroshima 730-8518, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Cancer Treatment Center, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masazumi","family":"Okajima","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, 7-33, Motomachi, Naka-ku, Hiroshima 730-8518, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"2021070811425550100_ref1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/MPA.0b013e3181ec1261","article-title":"The NANETS consensus guidelines for the diagnosis and management of gastrointestinal neuroendocrine tumors (nets): well-differentiated nets of the distal colon and rectum","volume":"39","author":"Anthony","year":"2010","journal-title":"Pancreas"},{"key":"2021070811425550100_ref2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1590\/abd1806-4841.20153189","article-title":"Mammary and extramammary Paget\u2019s disease","volume":"90","author":"Lopes Filho","year":"2015","journal-title":"An Bras 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Today"},{"key":"2021070811425550100_ref9","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/jjco\/hyl009","article-title":"T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma","volume":"36","author":"Kobayashi","year":"2006","journal-title":"Jpn J Clin Oncol"},{"key":"2021070811425550100_ref10","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1186\/s12885-018-5084-0","article-title":"Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report","volume":"18","author":"Yamamura","year":"2006","journal-title":"BMC Cancer"}],"container-title":["Journal of Surgical Case 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