{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:47Z","timestamp":1753877207023,"version":"3.41.2"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Amyloidosis was initially described by Nicolaes Fonteyn in 1639. It is caused by the deposition of soluble immunoglobulin light chains as insoluble fibrils and can affect any organ including the heart, nervous system, dermis and subcutaneous tissue, kidneys and liver. This is a rare case of cardiac amyloidosis occurring with multiple myeloma and pleural effusion.<\/jats:p>\n               <jats:p>A 65-year-old Arab woman, nonsmoker, nonalcoholic, known to have hypothyroidism and multiple myeloma, presented to the hospital with dyspnea and basilar crackles. Workup was done to exclude leukemia. Cardiac echography showed features of amyloidosis.<\/jats:p>\n               <jats:p>Cardiac amyloidosis occurring with multiple myeloma and pleural effusion is rare. However, it is stated that 10\u201315% of amyloidosis patients might develop multiple myeloma (MM).<\/jats:p>","DOI":"10.1093\/jscr\/rjab279","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T11:07:31Z","timestamp":1623755251000},"source":"Crossref","is-referenced-by-count":1,"title":["Cardiac amyloidosis with overt multiple myeloma presenting with pulmonary effusion: case report"],"prefix":"10.1093","volume":"2021","author":[{"given":"Wajih","family":"Saad","sequence":"first","affiliation":[{"name":"Oncology Department, Al Zahraa Hospital University Medical Center, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Moussa","sequence":"additional","affiliation":[{"name":"Urology Department, Al Zahraa Hospital University Medical Center and Lebanese University, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Medicine, Saint George Medical School University, Grenada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Dbouk","sequence":"additional","affiliation":[{"name":"Department of Surgery, Al Zahraa Hospital University Medical Center, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagham","family":"Bazzi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lebanese University, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"2021070811461874800_ref1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00059-020-04904-4","article-title":"Amyloid cardiomyopathy","volume":"45","author":"Kristen","year":"2020","journal-title":"Herz"},{"key":"2021070811461874800_ref2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.hemonc.2018.09.003","article-title":"Cutaneous light chain amyloidosis with multiple myeloma: a concise review","volume":"12","author":"Andrei","year":"2019","journal-title":"Hematol\/Oncol Stem Cell Ther"},{"key":"2021070811461874800_ref3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.rdc.2013.02.012","article-title":"Amyloidosis: a clinical overview","volume":"39","author":"Hazenberg","year":"2013","journal-title":"Rheumat Dis Clin North America"},{"key":"2021070811461874800_ref4","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.jacc.2016.06.053","article-title":"(Light-Chain) cardiac amyloidosis: a review of diagnosis and therapy","volume":"68","author":"Falk","year":"2016","journal-title":"J Am College Cardiol"},{"key":"2021070811461874800_ref5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5644\/ama2006-124.242","article-title":"Multiple myeloma genomics - a concise review","volume":"48","author":"Castaneda","year":"2019","journal-title":"Acta Med Acad"},{"key":"2021070811461874800_ref6","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1038\/nrdp.2017.46","article-title":"Multiple myeloma","volume":"3","author":"Kumar","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"2021070811461874800_ref7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jcu.20552","article-title":"Cardiac amyloidosis in a patient with multiple myeloma: a case report and review of literature","volume":"37","author":"Sedaghat","year":"2009","journal-title":"J Clin Ultras"},{"key":"2021070811461874800_ref8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ajg.2020.01.002","article-title":"Multiple myeloma with primary amyloidosis presenting with digestive symptoms: a case report and literature review","volume":"21","author":"Hu","year":"2020","journal-title":"Arab J Gastroenterol"},{"key":"2021070811461874800_ref9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nrclinonc.2011.63","article-title":"Treatment of multiple myeloma","volume":"8","author":"Rajkumar","year":"2011","journal-title":"Nat Rev Clin Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/6\/rjab279\/38840685\/rjab279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/6\/rjab279\/38840685\/rjab279.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T20:36:18Z","timestamp":1625776578000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjab279\/6311558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjab279","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2021,6]]},"published":{"date-parts":[[2021,6,1]]},"article-number":"rjab279"}}