{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:29Z","timestamp":1753877189131,"version":"3.41.2"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Described is a case of diffuse large B cell lymphoma that presented within a typical fistula tract, possibly secondary to oxidative stress within the fistula tract itself and consequent malignant change rather than a fistula as a consequence of necrosis in a lymphoma. If so it would be unique in the world literature. A 42-year-old fitness instructor presented with a typical appearing left lateral anal fistula. Biopsy of the fistulous tract revealed B cell lymphoma, graded 1E. Although chemotherapy cured the lymphoma, surgical treatment by ligation of the inter-sphincteric fistula tract was required to heal the fistula. At 3-year follow-up, there has been no recurrence of the lymphoma or the fistula. Neoplasia arising secondary to oxidative stress within an anal fistula is a well-established phenomenon. Early diagnosis of rare conditions associated with anal fistula can only be accomplished by routine biopsy of every fistula tract.<\/jats:p>","DOI":"10.1093\/jscr\/rjab360","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T19:09:49Z","timestamp":1627585789000},"source":"Crossref","is-referenced-by-count":2,"title":["Diffuse large B cell lymphoma within an anal fistula: a case report with an intriguing possible aetiology"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-0759","authenticated-orcid":false,"given":"James","family":"Kent","sequence":"first","affiliation":[{"name":"Bentley Health Service, Department of Surgery, Perth, WA 6102, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Joske","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital, Department of Haematology, Nedlands, WA 6009, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Parry","sequence":"additional","affiliation":[{"name":"Murdoch University, Department of Pathology, Murdoch, WA 6150, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"2021081623012081500_ref1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/1097-0142(19800701)46:1<215::AID-CNCR2820460136>3.0.CO;2-6","article-title":"Gastrointestinal involvement in non-Hodgkin\u2019s lymphoma","volume":"46","author":"Herrmann","year":"1980","journal-title":"Cancer"},{"key":"2021081623012081500_ref2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10151-013-1082-z","article-title":"Management of acute perianal sepsis in neutropenic patients with haematological malignancy","volume":"18","author":"Baker","year":"2014","journal-title":"Tech Coloproctol"},{"key":"2021081623012081500_ref3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1080\/11024150201680018","article-title":"Perianal abscess: an unusual presentation of non-Hodgkins lymphoma","volume":"168","author":"Ganeshan","year":"2002","journal-title":"Eur J Surg"},{"key":"2021081623012081500_ref4","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/1097-0142(19871001)60:7<1449::AID-CNCR2820600707>3.0.CO;2-8","article-title":"Primary anorectal lymphoma: a new manifestation of the acquired immunodeficiency syndrome (AIDS)","volume":"60","author":"Ioachim","year":"1987","journal-title":"Cancer"},{"key":"2021081623012081500_ref5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/bmj.291.6491.311","article-title":"Primary lymphoma of the anal canal presenting as perianal suppuration","volume":"291","author":"Steele","year":"1985","journal-title":"Br Med J"},{"key":"2021081623012081500_ref6","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1007\/BF02237108","article-title":"Perianal lymphoma in a heterosexual and non-immunocompromised patient. Report of a case and review of the literature","volume":"42","author":"Smith","year":"1999","journal-title":"Dis Colon Rectum"},{"key":"2021081623012081500_ref7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12029-011-9270-4","article-title":"Perianal lymphoma presenting as an abscess in a heterosexual and non-immunocompromised patient: report of a case","volume":"43","author":"Yaprak","year":"2012","journal-title":"J Gastrointest Cancer"},{"key":"2021081623012081500_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rju035","article-title":"Diffuse large B cell lymphoma presenting as peri-anal abscess","author":"Jayasekera","journal-title":"J Surg Case Rep"},{"key":"2021081623012081500_ref9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1055\/s-0031-1272824","article-title":"Neoplasms of the anal canal and perianal skin","volume":"24","author":"Leonard","year":"2011","journal-title":"Clin Colon Rectal Surg"},{"key":"2021081623012081500_ref10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/2325957414553838","article-title":"Plasmoblastic lymphoma as a cause of perianal fistula: a case report and literature review","volume":"14","author":"Isfahani","year":"2015","journal-title":"J Int Assoc Provid AIDS Care"},{"key":"2021081623012081500_ref11","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10151-016-1494-7","article-title":"Proinflammatory cytokines in cryptoglandular anal fistulas","volume":"20","author":"Van Onkelen","year":"2016","journal-title":"Tech Coloproctol"},{"key":"2021081623012081500_ref12","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1093\/carcin\/bgl013","article-title":"Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma","volume":"27","author":"Wang","year":"2006","journal-title":"Carcinogenesis"},{"key":"2021081623012081500_ref13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/1471-2407-11-343","article-title":"Malignant melanoma arising from a perianal fistula and harbouring a BRAF gene mutation: a case report","volume":"11","author":"Martinez-Cadenas","year":"2011","journal-title":"BMC Cancer"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/8\/rjab360\/39763685\/rjab360.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/8\/rjab360\/39763685\/rjab360.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T23:01:38Z","timestamp":1629154898000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjab360\/6353048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjab360","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2021,8]]},"published":{"date-parts":[[2021,8,1]]},"article-number":"rjab360"}}