{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:20:37Z","timestamp":1767651637648,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Carcinosarcoma ex pleomorphic adenoma is an extremely rare malignant neoplasm of the salivary gland that originates from a pre-existing benign tumor. Malignant transformation of the pleomorphic adenoma is extremely rare. The management of carcinosarcoma ex pleomorphic adenoma remains challenging because of its rarity, behavioral aggressiveness and resemblance to benign pleomorphic adenoma. Herein, we present the case of a 75-year-old male resident of Saudi Arabia with a history of a swelling in the right parotid gland for more than 25\u00a0years, which grew slowly with time. He underwent surgical removal with superficial parotidectomy. Afterward, histological examination of the resected tumor revealed features of carcinosarcoma, and he was diagnosed with carcinosarcoma ex pleomorphic adenoma. He presented again with recurrence of the tumor, which was managed with total parotidectomy and a combination of radiotherapy and chemotherapy. At 12-month follow-up, the patient showed no evidence of disease recurrence or distant metastasis.<\/jats:p>","DOI":"10.1093\/jscr\/rjab361","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T11:08:25Z","timestamp":1627643305000},"source":"Crossref","is-referenced-by-count":2,"title":["Carcinosarcoma ex pleomorphic adenoma of the parotid gland: a case report"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-2202","authenticated-orcid":false,"given":"Ali A","family":"Almubarak","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, King Saud bin Abdulziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman K","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Shaqra University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fareed R","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawan M","family":"Alahmadi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"2021081921301372900_ref1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.oraloncology.2011.04.020","article-title":"Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)","volume":"47","author":"Bj\u00f8rndal","year":"2011","journal-title":"Oral Oncol"},{"key":"2021081921301372900_ref2","first-page":"279","article-title":"Malignant mixed tumors of the salivary glands: a review","volume":"28","author":"Gnepp","year":"1993","journal-title":"Pathol Annu"},{"key":"2021081921301372900_ref3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0964-1955(92)90013-Q","article-title":"Histopathology of malignant salivary gland tumours","volume":"28","author":"Seifert","year":"1992","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"2021081921301372900_ref4","doi-asserted-by":"crossref","first-page":"812","DOI":"10.5858\/2001-125-0812-TMMTCO","article-title":"True malignant mixed tumor (carcinosarcoma) of parotid gland with unusual mesenchymal component: a case report and review of the literature","volume":"125","author":"Kwon","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"2021081921301372900_ref5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.oraloncology.2017.01.004","article-title":"Salivary gland pleomorphic adenoma in the Netherlands: a nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence","volume":"66","author":"Valstar","year":"2017","journal-title":"Oral Oncol"},{"key":"2021081921301372900_ref6","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.4314\/ahs.v19i4.50","article-title":"Carcinoma ex pleomorphic adenoma: a case report and review of literature","volume":"19","author":"Khanna","year":"2019","journal-title":"Afr Health Sci"},{"key":"2021081921301372900_ref7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00405-003-0698-4","article-title":"Neoplasms of the parotid gland in northern Poland, 1991-2000: an epidemiologic study","volume":"261","author":"Przewo\u017any","year":"2004","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2021081921301372900_ref8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.11604\/pamj.2016.23.66.5105","article-title":"Epidemiological and histopathological patterns of salivary gland tumors in Cameroon","volume":"23","author":"Sando","year":"2016","journal-title":"Pan Afr Med J"},{"key":"2021081921301372900_ref9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3174\/ajnr.A0974","article-title":"Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic- pathologic correlation with MR imaging including diffusion-weighted imaging","volume":"29","author":"Kato","year":"2008","journal-title":"AJNR Am J Neuroradiol"},{"key":"2021081921301372900_ref10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jamaoto.2015.3930","article-title":"A 20-year review of 75 cases of salivary duct carcinoma","volume":"142","author":"Gilbert","year":"2016","journal-title":"JAMA Otolaryngol-Head Neck Surg"},{"key":"2021081921301372900_ref11","first-page":"203","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"9","author":"Bernier","year":"2005","journal-title":"Cancer\/Radiotherapie"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/8\/rjab361\/39766825\/rjab361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/8\/rjab361\/39766825\/rjab361.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T21:31:44Z","timestamp":1629408704000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjab361\/6353397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjab361","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2021,8]]},"published":{"date-parts":[[2021,8,1]]},"article-number":"rjab361"}}