{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:03:10Z","timestamp":1770462190882,"version":"3.49.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignant peripheral nerve sheath tumors (MPNSTs), as defined by immunohistochemical evaluation, are identified along a spectrum ranging from atypical neurofibroma to high-grade MPNST because these tumors are similar in terms of cell shape and tissue components on hematoxylin\u2013eosin (HE) staining. The patient was a 57-year-old male referred to our hospital, with a recurrent red tumor at the anterior commissure of the larynx and submucosal swelling of the right vocal fold. A surgical specimen from a right horizontal partial laryngectomy was evaluated immunohistochemically. A high-grade MPNST lesion was included in the submucosal white tumor, whereas a low-grade MPNST lesion was encountered around the high-grade MPNST lesion. This tumor may involve different malignancies even when it is small. Although intra-tumor heterogeneity in cancers has been reported recently, careful immunohistochemical examination can be important and beneficial for eradicating the tumor while preserving vocal function.<\/jats:p>","DOI":"10.1093\/jscr\/rjab373","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T19:14:22Z","timestamp":1629400462000},"source":"Crossref","is-referenced-by-count":1,"title":["Laryngeal malignant peripheral nerve sheath tumor mixed with high- and low-grade malignancies"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8897-9174","authenticated-orcid":false,"given":"Taihei","family":"Kajiyama","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuka","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamitsu","family":"Hyodo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Kochi Medical School, Kochi University, Nankoku, 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