{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:10:52Z","timestamp":1767625852489,"version":"3.41.2"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recurrence of rectal cancer (RRC) affects up to one-third of patients. The survival is strictly dependent on the possibility of performing surgery without microscopic tumor residues (R0).<\/jats:p>\n               <jats:p>Electrochemotherapy (ECT) is based on the effect that electric pulsations have on increasing the permeability of the cell membrane to certain drugs. We propose the association of ECT to the surgical excision of perineal RRC in a 72-year-old male patient. Given the proximity between the recurrence and the urethra, it was decided to use ECT in order to clean any further neoplastic residues 10\u00a0mm from the surgical resection margin. Pelvic MRI at 4 and 7\u00a0months and clinical follow-up conducted for 9\u00a0months did not document disease recurrence. ECT combined with surgery can prove to be a valid choice in selected cases and could be the best treatment the patient is willing to accept.<\/jats:p>","DOI":"10.1093\/jscr\/rjab403","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:19:00Z","timestamp":1631099940000},"source":"Crossref","is-referenced-by-count":5,"title":["Use of electrochemotherapy in a combined surgical treatment of local recurrence of rectal cancer"],"prefix":"10.1093","volume":"2021","author":[{"given":"Paola","family":"Caprino","sequence":"first","affiliation":[{"name":"Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8704-2171","authenticated-orcid":false,"given":"Franco","family":"Sacchetti","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonietta","family":"Gambacorta","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo Eugenio","family":"Potenza","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Pastena","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Sofo","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS \u2013 Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"2021092821114042300_ref1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1463-1318.2006.01018.x","article-title":"Surgery for local recurrence of rectal cancer","volume":"8","author":"Heriot","year":"2006","journal-title":"Colorectal Dis"},{"key":"2021092821114042300_ref2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-bioeng-071813-104622","article-title":"Electroporation-Based Technologies for Medicine: Principles, Applications, and Challenge","volume":"16","author":"Yarmush","year":"2014","journal-title":"Annu Rev Biomed Eng"},{"key":"2021092821114042300_ref3","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1016\/0006-2952(88)90344-9","article-title":"Transient electropermeabilization of cells in culture: Increase of the cytotoxicity of anticancer drugs","volume":"37","author":"Orlowski","year":"1988","journal-title":"Biochem Pharmacol"},{"key":"2021092821114042300_ref4","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/s41416-018-0300-x","article-title":"Development of a best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours in the UK","volume":"119","author":"Watson","year":"2018","journal-title":"Br J Cancer"},{"key":"2021092821114042300_ref5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2482-13-43","article-title":"Intensified neoadjuvant radiochemotherapy for rectal cancer enhances surgical complications","volume":"13","author":"Schiffmann","year":"2013","journal-title":"BMC Surg"},{"key":"2021092821114042300_ref6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.5114\/jcb.2017.72603","article-title":"Is an interventional oncology center an advantage in the service of cancer patients or in the education? The Gemelli Hospital and INTERACTS experience","volume":"9","author":"Kov\u00e1cs","year":"2017","journal-title":"J Contemp Brachytherapy"},{"key":"2021092821114042300_ref7","first-page":"16","article-title":"Interventional oncology: should interventional radiotherapy (brachytherapy) be integrated into modern treatment procedures?","volume":"34","author":"Kov\u00e1cs","year":"2019","journal-title":"Turk Onkoloji Dergisi"},{"key":"2021092821114042300_ref8","first-page":"435","article-title":"VATE: VAlidation of high TEchnology based on large database analysis by learning machine","volume-title":"Colorectal Cancer","author":"Meldolesi","year":"2014"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/9\/rjab403\/40444175\/rjab403.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/9\/rjab403\/40444175\/rjab403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T21:44:28Z","timestamp":1632865468000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjab403\/6374321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,1]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjab403","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2021,9]]},"published":{"date-parts":[[2021,9,1]]},"article-number":"rjab403"}}