{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:05:58Z","timestamp":1753877158411,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Signet cell carcinoma of the appendix is the rarest and the most aggressive subtype of appendiceal malignancy, typically presenting with non-specific symptoms. We describe a case of a 62-year-old male with large bowel obstruction, with computed tomography demonstrating dilated large bowels from caecum to proximal sigmoid colon and pneumoperitoneum. Intraoperatively, closed loop obstruction caused by dense adherence of sigmoid colon to caecum was noted, which had resulted in caecal perforation. Histopathology study indicated primary appendiceal malignancy of signet cell morphology with intraperitoneal spread to sigmoid colon. Large bowel obstruction from appendiceal malignancy has rarely been reported and similar presentations have not been described in the existing literature. When left-sided large bowel obstruction is suspected to be caused by a malignant stricture, it is essential to consider transperitoneal spread of appendiceal malignancy as potential aetiology, particularly in the elderly.<\/jats:p>","DOI":"10.1093\/jscr\/rjab452","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T18:26:13Z","timestamp":1634581573000},"source":"Crossref","is-referenced-by-count":1,"title":["Closed loop large bowel obstruction due to appendiceal signet cell carcinoma"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3604-4438","authenticated-orcid":false,"given":"Du H","family":"Phan","sequence":"first","affiliation":[{"name":"Department of General Surgery, Hervey Bay Hospital, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua Y","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hervey Bay Hospital, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasikaran","family":"Nalliah","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hervey Bay Hospital, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"2021103114000018100_ref1","first-page":"22","article-title":"Signet ring cell carcinoma of the appendix presenting with intestinal obstruction","volume":"69","author":"Arcot","year":"2007","journal-title":"Indian J Surg"},{"key":"2021103114000018100_ref2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1477-7800-4-20","article-title":"Appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, a case report and literature review","volume":"4","author":"Aljarabah","year":"2007","journal-title":"Int Semin Surg 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Oncol"},{"key":"2021103114000018100_ref6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF02236899","article-title":"Appendiceal tumors","volume":"41","author":"Connor","year":"1998","journal-title":"Dis Colon Rectum"},{"key":"2021103114000018100_ref7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3810\/pgm.2008.11.1944","article-title":"Appendiceal carcinoma: a diagnostic and therapeutic challenge","volume":"120","author":"Subramanya","year":"2008","journal-title":"Postgrad Med"},{"key":"2021103114000018100_ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1258\/arsr.2012.120017","article-title":"Primary signet ring cell carcinoma of the appendix mimicking acute appendicitis","volume":"1","author":"Fusari","year":"2012","journal-title":"Acta Radiol Short Rep"},{"key":"2021103114000018100_ref9","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjaa139","article-title":"A rare case of signet ring cell carcinoma of the appendix","volume":"2020","author":"Caesar-Peterson","year":"2020","journal-title":"J Surg Case Rep"},{"key":"2021103114000018100_ref10","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4103\/0377-4929.130918","article-title":"Incidentally discovered goblet cell carcinoid clinically presenting as acute intestinal obstruction: a case report with review of literature","volume":"57","author":"Afroz","year":"2014","journal-title":"Indian J Pathol Microbiol"},{"key":"2021103114000018100_ref11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00595-008-3839-y","article-title":"Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case","volume":"39","author":"Suzuki","year":"2009","journal-title":"Surg Today"}],"container-title":["Journal of Surgical Case 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