{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:41:47Z","timestamp":1771670507310,"version":"3.50.1"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Granulomatosis with polyangiitis (GPA, formerly Wegener\u2019s) is a rare form of vasculitis, commonly affecting the upper and lower respiratory tract with simultaneous glomerulonephritis. Ear, nose and throat (ENT) manifestations account for the majority of presentations. The presence of antineutrophil cytoplasmic antibody is a recognized hallmark of GPA, but clinicians should remain cautious of false negative results. We describe a rare case of GPA presenting with concurrent middle ear disease and multiple lower cranial nerve palsies. Clinical judgment was affected by repeated negative autoimmune screens, and a definitive diagnosis was only achieved following renal biopsy. Reported cases of GPA presenting with mastoiditis or cranial nerve involvement are typically seropositive, with seronegative GPA following a less aggressive process. This case highlights the importance of clinical suspicion in the face of treatment resistant ENT pathology, and the need for early histopathological analysis. Early diagnosis and treatment are crucial in limiting disease progression.<\/jats:p>","DOI":"10.1093\/jscr\/rjab476","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T07:30:22Z","timestamp":1633505422000},"source":"Crossref","is-referenced-by-count":3,"title":["Seronegative granulomatosis with polyangiitis presenting as an acute skull base osteomyelitis with multiple cranial neuropathies"],"prefix":"10.1093","volume":"2021","author":[{"given":"Andrew","family":"Lotfallah","sequence":"first","affiliation":[{"name":"Otolaryngology, New Cross Hospital, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayan","family":"Shahidi","sequence":"additional","affiliation":[{"name":"Otolaryngology, New Cross Hospital, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven Wilhelm","family":"Odelberg","sequence":"additional","affiliation":[{"name":"Otolaryngology, New Cross Hospital, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Darr","sequence":"additional","affiliation":[{"name":"Otolaryngology, New Cross Hospital, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Mathews","sequence":"additional","affiliation":[{"name":"Otolaryngology, New Cross Hospital, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"2021102204345366300_ref1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.5114\/reum.2017.71643","article-title":"Two clinical cases of granulomatosis with polyangiitis with isolated otitis media and mastoiditis","volume":"55","author":"Kukushev","year":"2017","journal-title":"Reumatologia"},{"key":"2021102204345366300_ref2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-0038-1675759","article-title":"Head and neck manifestations of granulomatosis with polyangiitis: a retrospective analysis of 19 patients and review of the literature","volume":"23","author":"Carnevale","year":"2019","journal-title":"Int Arch Otorhinolaryngol"},{"key":"2021102204345366300_ref3","volume-title":"ANCA Positive Vasculitis","author":"Qasim","year":"2021"},{"key":"2021102204345366300_ref4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s004050100327","article-title":"Wegener's granulomatosis presenting with bilateral facial nerve palsy","volume":"258","author":"Nikolaou","year":"2001","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2021102204345366300_ref5","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/art.40577","article-title":"Epidemiology and outcomes of granulomatosis with polyangiitis (GPA) in pediatric and working-age adults populations in the United States: analysis of a large National Claims Database","volume":"70","author":"Panupattanapong","year":"2018","journal-title":"Arthritis Rhematol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/10\/rjab476\/40787496\/rjab476.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/10\/rjab476\/40787496\/rjab476.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T04:36:44Z","timestamp":1634877404000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjab476\/6406705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":5,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjab476","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10]]},"published":{"date-parts":[[2021,10,1]]},"article-number":"rjab476"}}