{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:47Z","timestamp":1753877087419,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oligometastatic disease is a relatively new concept that refers to an intermediate stage between disseminated and localized cancer. Most frequent locations for colorectal metastasis are lung and liver. We present an a typical case of an 85-year-old woman who was diagnosed with a low-grade adenocarcinoma in left colon; she underwent a left laparoscopic hemicolectomy which resulted in a stage IIIb. After 24\u00a0months of follow-up, an increase of carcinoembryonic antigen (CEA) leads to the diagnosis of two metastatic lesions in two uncommon locations: spleen and myometrium. Stepwise surgical resection of both lesions was performed without complications. Spleen and uterus are organs that are rarely affected in colorectal cancer, the affection of both organs being even more infrequent. Despite the atypicality, surgical treatment is a valid strategy in this case of oligometastatic disease, which enables the disease-free survival of the patients.<\/jats:p>","DOI":"10.1093\/jscr\/rjab577","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T20:11:38Z","timestamp":1638216698000},"source":"Crossref","is-referenced-by-count":1,"title":["Atypical double colorectal metastasis: spleen and uterus"],"prefix":"10.1093","volume":"2022","author":[{"given":"\u00c1lex","family":"Morera-Grau","sequence":"first","affiliation":[{"name":"General Surgery Department , Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Evangelina","family":"Patriarca-Amiano","sequence":"additional","affiliation":[{"name":"Pathology Department , Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2219-7687","authenticated-orcid":false,"given":"Pablo","family":"Santiago-D\u00edaz","sequence":"additional","affiliation":[{"name":"Pathology Department , Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Serrano-Munn\u00e9","sequence":"additional","affiliation":[{"name":"Pathology Department , Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetto","family":"Ielpo","sequence":"additional","affiliation":[{"name":"General Surgery Department , Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Burd\u00edo-Pinilla","sequence":"additional","affiliation":[{"name":"General Surgery Department , Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Pera-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"General Surgery Department , Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Espuelas-Mal\u00f3n","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department , Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Iglesias-Coma","sequence":"additional","affiliation":[{"name":"Pathology Department , Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"S\u00e1nchez-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"General Surgery Department , Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"2022072512191083500_ref1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s10147-010-0182-2","article-title":"Isolated splenic metastasis from colorectal cancer","volume":"16","author":"Abi Saad","year":"2011","journal-title":"Int J Clin Oncol"},{"key":"2022072512191083500_ref2","first-page":"277","article-title":"Two cases with atypical metastasis in colorectal cancer: splenic and renal metastasis","volume":"32","author":"Dogan","year":"2010","journal-title":"Exp Oncol"},{"key":"2022072512191083500_ref3","first-page":"143","article-title":"Isolated splenic metastasis from colon cancer","volume":"23","author":"Cavallaro","year":"2004","journal-title":"J Exp Clin Cancer Res"},{"key":"2022072512191083500_ref4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/ijc.2910180613","article-title":"Kinetics of the response of spleen cells from tumor-bearing animals in an in vivo tumor neutralization assay","volume":"18","author":"Gabizon","year":"1976","journal-title":"Int J Cancer"},{"key":"2022072512191083500_ref5","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1177\/000313480106700515","article-title":"Isolated colon cancer metastasis to the spleen","volume":"67","author":"Place","year":"2001","journal-title":"Am Surg"},{"key":"2022072512191083500_ref6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0301-2115(99)00043-3","article-title":"Sigmoid colon carcinoma metastatic to the myometrium","volume":"86","author":"Walfisch","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2022072512191083500_ref7","first-page":"499","article-title":"Splenic metastases. 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