{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T09:29:09Z","timestamp":1778232549489,"version":"3.51.4"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Leiomyomas are benign mesenchymal tumors derived from smooth muscles. Uterus is the commonest site of origin for leiomyomas; however, unusual growth patterns and locations have been reported posing diagnostic challenges, clinically and radiologically. Histological diagnosis remains the gold standard of diagnosis. Here, we present a 17-year-old female with a 3-month history of chest pain, cough, difficulty in breathing and chest tightness. Chest CT scan showed a 12.3\u00a0cm\u2009\u00d7\u200914.4\u00a0cm\u2009\u00d7\u200922.8\u00a0cm mass occupying the entire left posterior hemithorax. The patient underwent thoracotomy and recovered well after surgery. Histopathology of the excised specimen confirmed it to be leiomyoma. Despite its rarity, primary mediastinal leiomyoma should be considered in the differential diagnosis of an unexplained mediastinal mass. Its accurate pre-operative diagnosis is difficult. Respiratory compromise and risk of transformation to sarcoma mandate complete surgical resection for a definitive diagnosis and good prognosis.<\/jats:p>","DOI":"10.1093\/jscr\/rjab584","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T20:11:37Z","timestamp":1639599097000},"source":"Crossref","is-referenced-by-count":1,"title":["Ectopic uterus? A rare presentation of a giant leiomyoma in the posterior mediastinum"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4834-9995","authenticated-orcid":false,"given":"Murad","family":"Tarmohamed","sequence":"first","affiliation":[{"name":"Department of General Surgery, Kilimanjaro Christian Medical Centre, P.O. Box 3010, Moshi, Kilimanjaro, Tanzania"},{"name":"Kilimanjaro Christian Medical University College, P.O. Box 2240, Moshi, Kilimanjaro, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abednego","family":"Mashambo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Kilimanjaro Christian Medical Centre, P.O. Box 3010, Moshi, Kilimanjaro, Tanzania"},{"name":"Kilimanjaro Christian Medical University College, P.O. Box 2240, Moshi, Kilimanjaro, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Sadiq","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kilimanjaro Christian Medical Centre, P.O. Box 3010, Moshi, Kilimanjaro, Tanzania"},{"name":"Kilimanjaro Christian Medical University College, P.O. Box 2240, Moshi, Kilimanjaro, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-0168","authenticated-orcid":false,"given":"Alex","family":"Mremi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kilimanjaro Christian Medical Centre, P.O. Box 3010, Moshi, Kilimanjaro, Tanzania"},{"name":"Kilimanjaro Christian Medical University College, P.O. Box 2240, Moshi, Kilimanjaro, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kondo","family":"Chilonga","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Kilimanjaro Christian Medical Centre, P.O. Box 3010, Moshi, Kilimanjaro, Tanzania"},{"name":"Kilimanjaro Christian Medical University College, P.O. Box 2240, Moshi, Kilimanjaro, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"2022020903560520200_ref1","volume-title":"Leiomyoma-general","author":"Alran","year":"2021"},{"key":"2022020903560520200_ref2","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1148\/rg.287085095","article-title":"Leiomyomas beyond the uterus: unusual locations, rare manifestations","volume":"28","author":"Fasih","year":"2008","journal-title":"Radiographics"},{"key":"2022020903560520200_ref3","doi-asserted-by":"crossref","first-page":"E116","DOI":"10.21037\/jtd.2018.01.37","article-title":"Primary mediastinal leiomyoma: a rare case report and literature review","volume":"10","author":"Li","year":"2018","journal-title":"J Thorac Dis"},{"key":"2022020903560520200_ref4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4076\/1757-1626-2-8555","article-title":"Primary mediastinal leiomyoma: a case report","volume":"2","author":"Ouadnouni","year":"2009","journal-title":"Cases J"},{"key":"2022020903560520200_ref5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5761\/atcs.cr.16-00137","article-title":"Giant leiomyoma arising from the mediastinal pleura: a case report","volume":"23","author":"Haratake","year":"2017","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"2022020903560520200_ref6","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.athoracsur.2019.07.082","article-title":"Anterior and posterior mediastinum Leiomyomas arising from the parietal pleura","volume":"111","author":"Torres-Luna","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"2022020903560520200_ref7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3348\/jksr.2016.75.2.147","article-title":"Primary mediastinal leiomyoma mimicking a giant mediastinal cyst: a case report","volume":"75","author":"Hwang","year":"2016","journal-title":"J Korean Soc Radiol"},{"key":"2022020903560520200_ref8","first-page":"1409","article-title":"Benign metastasizing leiomyoma","volume-title":"Am J Roentgenol","year":"2001"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/12\/rjab584\/42431379\/rjab584.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2021\/12\/rjab584\/42431379\/rjab584.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T03:56:46Z","timestamp":1644379006000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjab584\/6482643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjab584","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12]]},"published":{"date-parts":[[2021,12,1]]},"article-number":"rjab584"}}