{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:10:27Z","timestamp":1778285427874,"version":"3.51.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T00:00:00Z","timestamp":1644105600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignant pleural mesothelioma represents a rare etiology of lung cancer metastasis to the brain. Neurologically symptomatic presentations are extremely rare as these metastatic lesions are detected in the late stages of the disease. Despite many highly heterogenous treatment techniques reported in the literature, overall survival is poor. A 72-year-old male with a history of mesothelioma presented with recurrent episodes of altered mental status, confusion and expressive aphasia. Imaging indicated a large hemorrhagic, enhancing lesion in the anterior left frontal lobe resulting in midline shift of 6\u00a0mm. He underwent a left frontal craniotomy for resection, after which he had complete resolution of symptoms. The resected mass was metastatic high-grade malignant mesothelioma. On a 1-month follow-up, new lesions in the bilateral frontal lobes were discovered, and despite undergoing adjuvant stereotactic radiosurgery, the right one grew significantly, causing notable mass effect. The patient successfully underwent a right craniotomy for resection.<\/jats:p>","DOI":"10.1093\/jscr\/rjac002","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T20:08:42Z","timestamp":1641240522000},"source":"Crossref","is-referenced-by-count":3,"title":["Cerebral metastases of malignant mesothelioma"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1205-1297","authenticated-orcid":false,"given":"Abhijith","family":"Bathini","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Department of Neurological Surgery, Allegheny Health Network, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorian M","family":"Kusyk","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Department of Neurological Surgery, Allegheny Health Network, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Stabingas","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Department of Neurological Surgery, Allegheny Health Network, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Kujawski","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Department of Neurological Surgery, Allegheny Health Network, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Department of Neurological Surgery, Allegheny Health Network, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Drexel University College of Medicine, Philadelphia, PA, USA"},{"name":"Department of Neurological Surgery, Allegheny Health Network, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,6]]},"reference":[{"key":"2022020901392972400_ref1","volume-title":"StatPearls [Internet]","author":"Jain","year":"2021"},{"key":"2022020901392972400_ref2","first-page":"S397","article-title":"Malignant pleural mesothelioma: current and future perspectives","volume":"5","author":"Porpodis","year":"2013","journal-title":"J Thorac Dis"},{"key":"2022020901392972400_ref3","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1513\/AnnalsATS.201404-165BC","article-title":"Malignant mesothelioma and central nervous system metastases. Report of two cases, pooled analysis, and systematic review","volume":"11","author":"Miller","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"2022020901392972400_ref4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF01054270","article-title":"Cerebral metastases in pleural mesothelioma: case report and review of the literature","volume":"17","author":"Wro\u0144ski","year":"1993","journal-title":"J Neurooncol"},{"key":"2022020901392972400_ref5","doi-asserted-by":"crossref","first-page":"rjt087","DOI":"10.1093\/jscr\/rjt087","article-title":"Cerebral metastasis from malignant pleural mesothelioma","volume":"2013","author":"El Molla","year":"2013","journal-title":"J Surg Case Rep"},{"key":"2022020901392972400_ref6","first-page":"CASE2099","article-title":"A case of brain metastasis with pathological transformation of long-surviving malignant pleural mesothelioma: illustrative case","volume":"1","author":"Noda","year":"2021","journal-title":"Journal of Neurosurgery: Case Lessons JNSCL"},{"key":"2022020901392972400_ref7","volume-title":"StatPearls [Internet]","author":"Amsbaugh","year":"2021"},{"key":"2022020901392972400_ref8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s004200100240","article-title":"Malignant mesothelioma--German mesothelioma register 1987-1999","volume":"74","author":"Neumann","year":"2001","journal-title":"Int Arch Occup Environ Health"},{"key":"2022020901392972400_ref9","first-page":"e241","article-title":"Cerebral metastasis of a malignant pleural mesothelioma: a case report and review of the literature","volume":"7","author":"Chari","year":"2015","journal-title":"Cureus"},{"key":"2022020901392972400_ref10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.clon.2012.10.001","article-title":"Nervous system metastases from malignant mesothelioma","volume":"25","author":"Martinez","year":"2013","journal-title":"Clin Oncol (R Coll Radiol)"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/2\/rjac002\/42405333\/rjac002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/2\/rjac002\/42405333\/rjac002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T02:06:43Z","timestamp":1644372403000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjac002\/6523270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjac002","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2]]},"published":{"date-parts":[[2022,2,1]]},"article-number":"rjac002"}}