{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:56:25Z","timestamp":1761630985520,"version":"3.41.2"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Peutz-Jeghers syndrome (PJS) is an autosomal dominant mutation of the STK11\/LKB1 gene on chromosome 19 often characterized by mucocutaneous pigmentation, hamartomatous polyps, anemia, gastrointestinal bleeding and intussusception. We present the case of a 21-year-old female with no pertinent family history who received the diagnosis of PJS after presenting to the hospital with two episodes intussusception. Patients with PJS have an increased lifetime risk of developing stomach, small bowel, colon, pancreatic, breast, cervical, uterus and testicular cancer requiring religious surveillance at an early age.<\/jats:p>","DOI":"10.1093\/jscr\/rjac070","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T12:07:50Z","timestamp":1646222870000},"source":"Crossref","is-referenced-by-count":4,"title":["A case of sporadic Peutz-Jeghers syndrome presenting as multiple intussusceptions"],"prefix":"10.1093","volume":"2022","author":[{"given":"Leva","family":"Gorji","sequence":"first","affiliation":[{"name":"Kettering Health \u2013 Washington Township, Department of Surgery, Washington Township, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Huish","sequence":"additional","affiliation":[{"name":"Kettering Health \u2013 Washington Township, Department of Surgery, Washington Township, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Morgan","sequence":"additional","affiliation":[{"name":"Kettering Health \u2013 Washington Township, Department of Surgery, Washington Township, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Levy","sequence":"additional","affiliation":[{"name":"Kettering Health \u2013 Washington Township, Department of Surgery, Washington Township, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"volume-title":"Cleveland Clinic","author":"Peutz-Jeghers syndrome: symptoms, causes, treatments","key":"2022031004483880800_ref1"},{"volume-title":"Arch Clin Med Case Rep","year":"2020","author":"Sabrine","key":"2022031004483880800_ref2"},{"key":"2022031004483880800_ref3","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/gut.2009.198499","article-title":"Peutz-Jeghers syndrome: a systematic review and recommendations for management","volume":"59","author":"Beggs","year":"2010","journal-title":"Gut"},{"key":"2022031004483880800_ref4","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1053\/gast.2000.20228","article-title":"Very high risk of cancer in familial Peutz-Jeghers syndrome","volume":"119","author":"Giardiello","year":"2000","journal-title":"Gastroenterology"},{"key":"2022031004483880800_ref5","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1158\/1078-0432.CCR-06-0083","article-title":"Frequency and spectrum of cancers in the Peutz-Jeghers syndrome","volume":"12","author":"Hearle","year":"2006","journal-title":"Clin Cancer Res"},{"volume-title":"Peutz Jeghers syndrome","year":"2018","author":"Leveille","key":"2022031004483880800_ref6"},{"key":"2022031004483880800_ref7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000351885","article-title":"Rectal carcinoma in a young female patient with Peutz-Jeghers syndrome: a case report","volume":"23","author":"Tsai","year":"2014","journal-title":"Med Princ Pract"},{"key":"2022031004483880800_ref8","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/jmg.2004.026294","article-title":"STK11 genotyping and cancer risk in Peutz-Jeghers syndrome","volume":"42","author":"Schumacher","year":"2005","journal-title":"J Med Genet"},{"key":"2022031004483880800_ref9","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/gutjnl-2012-303108","article-title":"For the International Cancer of Pancreas Screening (CAPS) consortium. International Cancer of the Pancreas Screening (CAPS) consortium summit on the management of patients with increased risk for familial pancreatic cancer","volume":"62","author":"Canto","year":"2013","journal-title":"Gut"},{"key":"2022031004483880800_ref10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.humpath.2015.10.002","article-title":"Morphologic characterization of hamartomatous gastrointestinal polyps in Cowden syndrome, Peutz-Jeghers syndrome, and juvenile polyposis syndrome","volume":"49","author":"Shaco-Levy","year":"2016","journal-title":"Hum Pathol"},{"key":"2022031004483880800_ref11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.12998\/wjcc.v8.i3.577","article-title":"Peutz-Jeghers syndrome with mesenteric fibromatosis: a case report and review of literature","volume":"8","author":"Cai","year":"2020","journal-title":"World J Clin Cases"},{"key":"2022031004483880800_ref12","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/ajg.2009.725","article-title":"High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations","volume":"105","author":"Lier","year":"2010","journal-title":"Am J Gastroenterol"},{"volume-title":"Cancer.Net","year":"2020","author":"Peutz-Jeghers syndrome","key":"2022031004483880800_ref13"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/3\/rjac070\/42778958\/rjac070.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/3\/rjac070\/42778958\/rjac070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T04:48:57Z","timestamp":1646887737000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjac070\/6545277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjac070","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2022,3]]},"published":{"date-parts":[[2022,3,1]]},"article-number":"rjac070"}}