{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:05:03Z","timestamp":1753877103059,"version":"3.41.2"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Severe coronavirus disease of 2019 (COVID-19) disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes substantial parenchymal damage in some patients. There is a paucity of literature describing the surgical management COVID-19 associated bronchopleural fistula after failure of medical therapy. We present the case of a 59-year-old woman with SARS-CoV-2 pneumonia, secondary bacterial pneumonia with bronchopleural fistula and radiographic and clinical evidence of disease refractory to medical therapy. After a course of culture-driven antimicrobial therapy and failure to improve following drainage with tube thoracostomy, she was treated successfully with Clagett open thoracostomy. After resolution of the bronchopleural fistula, the thoracostomy was closed and she was discharged home. In cases of severe COVID-19 complicated by bronchopleural fistula with parenchymal destruction, a tailored approach involving surgical management when indicated can lead to acceptable outcomes without significant morbidity.<\/jats:p>","DOI":"10.1093\/jscr\/rjac076","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T12:08:06Z","timestamp":1645272486000},"source":"Crossref","is-referenced-by-count":1,"title":["Bronchopleural fistula due to cavitary pneumonia after SARS-CoV-2 infection treated with open thoracostomy"],"prefix":"10.1093","volume":"2022","author":[{"given":"Leonid A","family":"Belyayev","sequence":"first","affiliation":[{"name":"Department of Surgery, Veterans Affairs Medical Center, West Roxbury, MA 02132, USA"},{"name":"Department of Surgery, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5036-3868","authenticated-orcid":false,"given":"Sophia M","family":"Foroushani","sequence":"additional","affiliation":[{"name":"Department of Surgery, Veterans Affairs Medical Center, West Roxbury, MA 02132, USA"},{"name":"Department of Surgery, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C","family":"Wiener","sequence":"additional","affiliation":[{"name":"Department of Surgery, Veterans Affairs Medical Center, West Roxbury, MA 02132, USA"},{"name":"Department of Surgery, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Westyn","family":"Branch-Elliman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Veterans Affairs Medical Center, West Roxbury, MA 02132, USA"},{"name":"Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Blair","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan A","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Surgery, Veterans Affairs Medical Center, West Roxbury, MA 02132, USA"},{"name":"Department of Surgery, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"2022041213272871900_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-92220-0","article-title":"Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients","volume":"11","author":"Shafran","year":"2021","journal-title":"Sci Rep"},{"key":"2022041213272871900_ref2","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1513\/AnnalsATS.202009-1093RL","article-title":"Secondary bacterial pneumonias and bloodstream infections in patients hospitalized with COVID-19","volume":"18","author":"Adelman","year":"2021","journal-title":"Ann Am Thorac Soc"},{"key":"2022041213272871900_ref3","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3949\/ccjm.87a.ccc015","article-title":"Recognition and management of respiratory coinfection and secondary bacterial pneumonia in patients with COVID-19: posted April 27, 2020","volume":"87","author":"Wu","year":"2020","journal-title":"Cleve Clin J Med"},{"key":"2022041213272871900_ref4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/icvts\/ivaa238","article-title":"Cavitary lung lesions and pneumothorax in a healthy patient with active Coronavirus-19 (COVID-19) viral pneumonia","volume":"32","author":"Afrazi","year":"2021","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"2022041213272871900_ref5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1155\/2006\/760390","article-title":"Surgical management of acute necrotizing lung infections","volume":"13","author":"Reimel","year":"2006","journal-title":"Can Respir J"},{"key":"2022041213272871900_ref6","first-page":"76","article-title":"Bronchopleural fistulas","volume":"3","author":"Noppen","year":"2007","journal-title":"Int J Respir Care"},{"key":"2022041213272871900_ref7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.21037\/shc.2017.06.01","article-title":"Surgical approaches for bronchopleural fistula","volume":"1","author":"Dal Agnol","year":"2017","journal-title":"Shanghai Chest"},{"key":"2022041213272871900_ref8","article-title":"Bronchopleural fistula as a complication in a COVID-19 patient managed with endobronchial valves","volume":"9","author":"Talon","year":"2021","journal-title":"J Investig Med High Impact Case Reports"},{"key":"2022041213272871900_ref9","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.4103\/lungindia.lungindia_914_20","article-title":"Use of endobronchial valve to treat COVID-19 adult respiratory distress syndrome-related alveolopleural fistula","volume":"38","author":"Pathak","year":"2021","journal-title":"Lung India"}],"container-title":["Journal of Surgical Case 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