{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:31:00Z","timestamp":1787682660900,"version":"build-2784847793"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Retroperitoneal lipoma is exceedingly rare, and due to the difficulty in distinguishing between retroperitoneal lipoma and well-differentiated liposarcoma (WDLS), recommendation is en-bloc resection. A 58-year-old male was investigated for scrotal swelling, ultrasound and computed tomography showed a well-defined lipomatous mass occupying much of the left side of the lower abdomen. At laparotomy, a large left-sided retroperitoneal mass was found. Histology reported a 160\u00a0mm \u00d7 150\u00a0mm \u00d7 90\u00a0mm fatty tumour weighing 1540\u00a0g. MDM2 gene amplification was not present on fluorescence in situ hybridization. No significant somatic signatures were identified on whole exome sequencing. Retroperitoneal fatty tumours represent a diagnostic dilemma. Sampling via core biopsy has been recorded at 85% accuracy for WDLS. Positive amplification of the MDM2 gene supports a diagnosis of WDLS; however, a negative biopsy does not exclude the diagnosis due to varied amplification among different cells in the same tumour.<\/jats:p>","DOI":"10.1093\/jscr\/rjac121","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T20:09:54Z","timestamp":1646942994000},"source":"Crossref","is-referenced-by-count":4,"title":["A rare case of a giant retroperitoneal lipoma with multiple limb and trunk lipomata without familial multiple lipomatosis"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-5306","authenticated-orcid":false,"given":"Jason R","family":"Laurens","sequence":"first","affiliation":[{"name":"Upper Gastro-intestinal and Soft Tissue Unit, Princess Alexandra Hospital, Woolloongabba, QLD, Australia"},{"name":"C\/O Department of Surgical Specialties, Princess Alexandra Hospital, Woolloongabba, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J","family":"Frankel","sequence":"additional","affiliation":[{"name":"Upper Gastro-intestinal and Soft Tissue Unit, Princess Alexandra Hospital, Woolloongabba, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard M","family":"Smithers","sequence":"additional","affiliation":[{"name":"Upper Gastro-intestinal and Soft Tissue Unit, Princess Alexandra Hospital, Woolloongabba, QLD, Australia"},{"name":"Mayne Professor and Head, Discipline of Surgery, The University of Queensland, Woolloongabba, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Strutton","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,26]]},"reference":[{"key":"2022032913495864800_ref1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/aid2.13126","article-title":"Giant retroperitoneal lipoma presenting as abdominal protrusion: one case report and review of literature","volume":"6","author":"Chen","year":"2019","journal-title":"Adv Dig Med"},{"key":"2022032913495864800_ref2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.eucr.2018.08.020","article-title":"Fatty tumors of the retroperitoneum: lipoma or well-differentiated liposarcoma. 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