{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:28Z","timestamp":1753877188419,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 55-year-old woman with previous skin-sparing mastectomy and prosthetic reconstruction for multifocal ductal carcinoma developed homolateral axillary recurrence. Following nodal dissection, partial periprosthetic capsulectomy and the overlying breast skin excision, the pathology report revealed a positive cutaneous margin. Since further breast skin excision or radiotherapy would have compromised the prosthetic implant, and the patient was adamant about avoiding any endangering intervention, the multidisciplinary recommendation included skin-directed electrochemotherapy (ECT) in the frame of a multimodal treatment strategy. The procedure lasted 20\u00a0minutes under mild general sedation and included a bolus of intravenous bleomycin followed by local application of electric pulses using a needle electrode. The postprocedural course was uneventful, except for mild dermatologic toxicity. At 5 years, the patient is disease-free with the implant in situ. This report illustrates the proof-of-concept of adjuvant skin-sparing ECT to sterilize resection margins, preserve a breast implant and highlight procedural details to avert toxicity.<\/jats:p>","DOI":"10.1093\/jscr\/rjac199","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T19:14:44Z","timestamp":1650482084000},"source":"Crossref","is-referenced-by-count":2,"title":["Adjuvant skin-sparing electrochemotherapy in a breast cancer patient with a prosthetic implant: 5-year follow-up outcomes"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8466-8459","authenticated-orcid":false,"given":"Luca G","family":"Campana","sequence":"first","affiliation":[{"name":"Department of Surgery, The Christie NHS Foundation Trust, Manchester, UK"},{"name":"Department of Surgery, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Balestrieri","sequence":"additional","affiliation":[{"name":"Breast Unit, ULSS 2 Marca Trevigiana, Vittorio Veneto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Menin","sequence":"additional","affiliation":[{"name":"Breast Unit, ULSS 2 Marca Trevigiana, Vittorio Veneto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"2022051817341395500_ref1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1054\/bjoc.2000.1625","article-title":"Electroporation of human microvascular endothelial cells: evidence for an anti-vascular mechanism of electrochemotherapy","volume":"84","author":"Cemazar","year":"2001","journal-title":"Br J Cancer"},{"key":"2022051817341395500_ref2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1586\/era.10.43","article-title":"Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases","volume":"10","author":"Jarm","year":"2010","journal-title":"Expert Rev Anticancer Ther"},{"key":"2022051817341395500_ref3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0277-5379(91)90064-K","article-title":"Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses","volume":"27","author":"Mir","year":"1991","journal-title":"Eur J Cancer"},{"key":"2022051817341395500_ref4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10555-016-9615-3","article-title":"The promising alliance of anti-cancer electrochemotherapy with immunotherapy","volume":"35","author":"Calvet","year":"2016","journal-title":"Cancer Metastasis Rev"},{"key":"2022051817341395500_ref5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ctrv.2011.07.006","article-title":"Electrochemotherapy of chest wall breast cancer recurrence","volume":"38","author":"Sersa","year":"2012","journal-title":"Cancer Treat Rev"},{"key":"2022051817341395500_ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10585-020-10063-x","article-title":"Electrochemotherapy of skin metastases from breast cancer: a systematic review","volume":"38","author":"Ferioli","year":"2021","journal-title":"Clin Exp Metastasis"},{"key":"2022051817341395500_ref7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cps.2017.08.001","article-title":"Radiation therapy and immediate breast reconstruction: novel approaches and evidence base for radiation effects on the reconstructed breast","volume":"45","author":"See","year":"2018","journal-title":"Clin Plast Surg"},{"key":"2022051817341395500_ref8","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/jdv.14708","article-title":"Electrochemotherapy of unresectable cutaneous tumours with reduced dosages of intravenous bleomycin: analysis of 57 patients from the International Network for Sharing Practices of Electrochemotherapy registry","volume":"32","author":"Rotunno","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2022051817341395500_ref9","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/jso.26725","article-title":"Locoregional recurrence in skin-sparing and nipple-sparing mastectomies","volume":"125","author":"Costeira","year":"2022","journal-title":"J Surg Oncol"},{"key":"2022051817341395500_ref10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/j.seminoncol.2019.04.002","article-title":"Electrochemotherapy of superficial tumors - 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