{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:02Z","timestamp":1753877222831,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Due to advances in retroviral treatment, human immunodeficiency virus (HIV)-related disease may become chronic and the patient survival has substantially increased. Osteoarticular disease in those patients include multifocal osteonecrosis and its complications. Pain and functional limitation may be due to these complications, frequently underdiagnosed, including pathological fractures. Its prompt management may require a different approach than osteosynthesis. We present a long-term chronic HIV patient with severe pain and limitation. A tibial plateau pathological fracture associated to multifocal osteonecrosis was identified and treated with osteonecrosis debridement and total knee arthroplasty (TKA). Acute periprosthetic joint infection developed and required debridement, antibiotic and implant retention. The contralateral knee, also with multiple osteonecrosis foci, was managed with early TKA. We highlight the importance of timely surgical reconstruction to avoid serious limitation and complications.<\/jats:p>","DOI":"10.1093\/jscr\/rjac223","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T21:29:56Z","timestamp":1654896596000},"source":"Crossref","is-referenced-by-count":0,"title":["Complications and surgical treatment after pathological fracture associated to HIV secondary disease. A case report"],"prefix":"10.1093","volume":"2022","author":[{"given":"Jorge","family":"Fuentes-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Orthopaedic Surgery and Traumatology Department , Hospital Universitario La Paz, P\u00b0 Castellana 261, 28046 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-6137","authenticated-orcid":false,"given":"Enrique","family":"G\u00f3mez-Barrena","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery and Traumatology Department , Hospital Universitario La Paz, Universidad Aut\u00f3noma de Madrid, P\u00b0 Castellana 261, 28046 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"2022061021294148900_ref1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1097\/QAD.0b013e32832ce85a","article-title":"Metabolic bone disease in HIV infection","volume":"23","author":"Borderi","year":"2009","journal-title":"AIDS"},{"key":"2022061021294148900_ref2","first-page":"515","article-title":"Musculoskeletal disorders in HIV-infected patients. National AIDS plan (PNS) and the AIDS study group (GESIDA)","volume":"29","year":"2011","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"2022061021294148900_ref3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00256-004-0764-z","article-title":"Musculoskeletal disorders associated with HIV infection and AIDS. Part I: infectious musculoskeletal conditions","volume":"33","author":"Tehranzadeh","year":"2004","journal-title":"Skeletal Radiol"},{"key":"2022061021294148900_ref4","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.RVW.17.00029","article-title":"Human immunodeficiency virus infection and hip and knee arthroplasty","volume":"5","author":"Dimitriou","year":"2017","journal-title":"JBJS Rev"},{"key":"2022061021294148900_ref5","first-page":"102","article-title":"Outcomes of total joint arthroplasty in HIV patients","volume":"34","author":"Falakassa","year":"2014","journal-title":"Iowa Orthop J"},{"key":"2022061021294148900_ref6","article-title":"Total joint arthroplasty in HIV-positive patients in Malawi: outcomes from the National Arthroplasty Registry of the Malawi Orthopaedic Association","volume":"6","author":"Graham","year":"2021","journal-title":"JB JS Open Access"},{"key":"2022061021294148900_ref7","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s00198-020-05350-y","article-title":"People living with HIV and fracture risk","volume":"31","author":"Premaor","year":"2020","journal-title":"Osteoporos Int"},{"key":"2022061021294148900_ref8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1051\/sicotj\/2020035","article-title":"Coinfection of HIV and hepatitis C increases complication rates after total joint arthroplasty","volume":"6","author":"Fang","year":"2020","journal-title":"Sicot J"},{"key":"2022061021294148900_ref9","first-page":"329","article-title":"One-year follow-up of orthopaedic implants in HIV-positive patients","volume":"28","author":"Harrison","year":"2004","journal-title":"Int Orthop"},{"key":"2022061021294148900_ref10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jor.2020.01.023","article-title":"Fracture-related infections in HIV infected patients: a systematic review and meta-analysis","volume":"18","author":"Nieuwoudt","year":"2020","journal-title":"J Orthop"},{"key":"2022061021294148900_ref11","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1302\/0301-620X.93B5.26081","article-title":"The effect of HIV on early wound healing in open fractures treated with internal and external fixation","volume":"93","author":"Aird","year":"2011","journal-title":"J Bone Joint Surg Br"},{"key":"2022061021294148900_ref12","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00590-015-1595-4","article-title":"An observational case series of HIV-positive patients treated with open reduction internal fixation for a closed lower extremity fracture","volume":"25","author":"Hao","year":"2015","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"2022061021294148900_ref13","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s00264-016-3285-1","article-title":"Fracture management in HIV positive individuals: a systematic review","volume":"40","author":"Wijesekera","year":"2016","journal-title":"Int Orthop"},{"key":"2022061021294148900_ref14","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.12669\/pjms.336.13368","article-title":"Analysis of the surgical treatment of fracture in HIV positive patients: a clinical study","volume":"33","author":"Xu","year":"2017","journal-title":"Pak J Med Sci"},{"key":"2022061021294148900_ref15","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.12023","article-title":"The association between serum CD4 T lymphocyte counts and surgical outcomes in HIV\/AIDS patients in Guangxi, China: a retrospective cohort study","volume":"9","author":"Liu","year":"2021","journal-title":"Peer J"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/6\/rjac223\/44008255\/rjac223.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/6\/rjac223\/44008255\/rjac223.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T21:30:11Z","timestamp":1654896611000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjac223\/6605240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjac223","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2022,6]]},"published":{"date-parts":[[2022,6,1]]},"article-number":"rjac223"}}