{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:36:35Z","timestamp":1785879395742,"version":"3.56.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neuroendocrine tumors are extremely rare in the middle ear. These tumors represent a spectrum of tumors with a diverse range of molecular abnormalities, functionality and anatomical locations. We present a rare case of middle ear neuroendocrine tumor, review the pathology and differential diagnosis of the tumors, and discuss the management and follow-up of patients with these tumors. We suspect that the middle ear neuroendocrine tumor is underdiagnosed and more cases can be detected through education and personal experience. Treatment is surgical resection, and long follow-up is recommended.<\/jats:p>","DOI":"10.1093\/jscr\/rjac257","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T22:51:47Z","timestamp":1655506307000},"source":"Crossref","is-referenced-by-count":8,"title":["Middle ear neuroendocrine tumor: a case report"],"prefix":"10.1093","volume":"2022","author":[{"given":"Azeddine","family":"Lachkar","sequence":"first","affiliation":[{"name":"ENT and Head and Neck Surgery Department, University Hospital Center Mohammed VI , Faculty of Medicine and Pharmacy, , Oujda, Morocco"},{"name":"Mohammed First University , Faculty of Medicine and Pharmacy, , Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drissia","family":"Benfadil","sequence":"additional","affiliation":[{"name":"ENT and Head and Neck Surgery Department, University Hospital Center Mohammed VI , Faculty of Medicine and Pharmacy, , Oujda, Morocco"},{"name":"Mohammed First University , Faculty of Medicine and Pharmacy, , Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahd","family":"Elayoubi","sequence":"additional","affiliation":[{"name":"ENT and Head and Neck Surgery Department, University Hospital Center Mohammed VI , Faculty of Medicine and Pharmacy, , Oujda, Morocco"},{"name":"Mohammed First University , Faculty of Medicine and Pharmacy, , Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"2022061722514008800_ref1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41574-020-00458-x","article-title":"Diagnostic and therapeutic advances in neuroendocrine tumours","volume":"17","author":"Caplin","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"2022061722514008800_ref2","first-page":"3453","article-title":"Neuroendocrine neoplasms of the middle ear: report of 2 cases and review of the literature","volume":"12","author":"He","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"2022061722514008800_ref3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12022-021-09684-z","article-title":"Middle ear \"adenoma\": a neuroendocrine tumor with predominant L cell differentiation","volume":"32","author":"Asa","year":"2021","journal-title":"Endocr Pathol"},{"key":"2022061722514008800_ref4","doi-asserted-by":"crossref","first-page":"e13031","DOI":"10.1111\/jne.13031","article-title":"Middle ear neuroendocrine tumours: Insight into their pathogenesis, diagnosis and management","volume":"33","author":"Ratnayake","year":"2021","journal-title":"J Neuroendocrinol"},{"key":"2022061722514008800_ref5","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s12105-018-0924-4","article-title":"Neuroendocrine neoplasms of the ear","volume":"12","author":"Katabi","year":"2018","journal-title":"Head Neck Pathol"},{"key":"2022061722514008800_ref6","doi-asserted-by":"crossref","first-page":"014556132110297","DOI":"10.1177\/01455613211029785","article-title":"Middle ear adenomatous neuroendocrine tumor: a rare entity","author":"Marini","year":"2021","journal-title":"Ear Nose Throat J"},{"key":"2022061722514008800_ref7","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/ccr3.3767","article-title":"Neuroendocrine adenoma of the middle ear\u2014an intriguing entity","volume":"9","author":"Rahal","year":"2021","journal-title":"Clin Case Rep"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/6\/rjac257\/44112612\/rjac257.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/6\/rjac257\/44112612\/rjac257.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T22:51:50Z","timestamp":1655506310000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjac257\/6609526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjac257","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6]]},"published":{"date-parts":[[2022,6,1]]},"article-number":"rjac257"}}