{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:05:11Z","timestamp":1766268311717,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chondrosarcoma is a highly aggressive malignant tumor originating from cartilaginous and mesenchymal tissues. The aim of this report is to describe a rare case of nasosinusal chondrosarcoma with orbito-cerebral extension. Our patient was a 55-year-old with a right cheek swelling evolving over a year, with unilateral right nasal obstruction gradually becoming bilateral associated with hyposmia, bilateral exophthalmos, reduced bilateral deep visual acuity and permanent headaches. The clinical examination found a tumor obstructing the two nasal cavities. Imaging showed a lobulated heterogeneous tissue process occupying the paranasal sinuses, with calcifications and enhancement at its periphery, extending to the orbito-cerebral area. The histopathological analysis was in favor of chondrosarcoma. The patient was first treated with an incomplete surgical resection by an endonasal route due to the extension to the orbit and the brain and received adjuvant radiotherapy. Surgical excision is a prognostic factor in this type of sarcomas and reduces recurrence rates.<\/jats:p>","DOI":"10.1093\/jscr\/rjac286","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T14:59:31Z","timestamp":1655909971000},"source":"Crossref","is-referenced-by-count":3,"title":["Nasosinusal chondrosarcoma with orbito-cerebral extension"],"prefix":"10.1093","volume":"2022","author":[{"given":"Khalid","family":"Bouhafs","sequence":"first","affiliation":[{"name":"Otorhinolaryngology and Head and Neck Surgery Department , Mohammed VI University Hospital of Oujda, Oujda, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azeddine","family":"Lachkar","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Head and Neck Surgery Department , Mohammed VI University Hospital of Oujda, Oujda, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayeb","family":"Bouamama","sequence":"additional","affiliation":[{"name":"Radiology Department , Mohammed VI University Hospital Center of Oujda, Oujda, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achraf","family":"Miry","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Department , Mohammed VI University Hospital Center of Oujda, Oujda, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drissia","family":"Benfadil","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Head and Neck Surgery Department , Mohammed VI University Hospital of Oujda, Oujda, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Rachid","family":"Ghailan","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Head and Neck Surgery Department , Mohammed VI University Hospital of Oujda, Oujda, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"2022062214592250400_ref1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1302\/0301-620X.48B4.729","article-title":"Chondrosarcoma of the bone","volume":"48-B","author":"Barnes","year":"1966","journal-title":"J Bone Joint Surg"},{"key":"2022062214592250400_ref2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/1097-0347(200007)22:4<408::AID-HED15>3.0.CO;2-H","article-title":"National cancer database report on chondrosarcoma of the head and neck","volume":"22","author":"Koch","year":"2000","journal-title":"Head Neck"},{"key":"2022062214592250400_ref3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/hed.2890030110","article-title":"The pathology of the head and neck tumors: neoplasm of cartilage, bone and the notochord, part 7","volume":"3","author":"Batsakis","year":"1980","journal-title":"Head Neck 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