{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:37Z","timestamp":1753877197766,"version":"3.41.2"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cancer metastasis to appendix vermiformis is rare. We here report a case of appendiceal metastasis of gastric cancer, which was incidentally discovered in the appendix resected as acute appendicitis. A 65-year-old man, who had undergone distal gastrectomy for poorly differentiated adenocarcinoma 2\u00a0years before, complained of lower abdominal pain. Physical examination and laboratory tests clinically suggested acute appendicitis. Macroscopically, the serosal surface of the resected appendix was hyperaemic and white-coated. These findings were compatible with the clinical diagnosis. However, histological examination revealed intra-mural invasion of poorly differentiated adenocarcinoma. The appendix serosal and mucosal surfaces were spared from cancer involvement. As the morphological appearance of adenocarcinoma and associated extensive lymphatic invasion was similar to those seen in the primary gastric cancer, the adenocarcinoma observed in the appendix was diagnosed as a metastasis. Possible routes of metastasis to the appendix from stomach were discussed with a brief review of relevant literature.<\/jats:p>","DOI":"10.1093\/jscr\/rjac322","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T19:57:27Z","timestamp":1657310247000},"source":"Crossref","is-referenced-by-count":2,"title":["Appendiceal metastasis of gastric cancer clinically masquerading acute appendicitis: possible route of metastasis"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-2196","authenticated-orcid":false,"given":"Takahiko","family":"Sakuma","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology , Toyohashi Medical Centre, Toyohashi Aichi, Japan"},{"name":"Department of Pathology , Nagoya Medical Centre, Nagoya Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Surgery , Nagoya Medical Centre, Nagoya Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Department of Pathology , Nagoya Medical Centre, Nagoya Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"2022070819572062800_ref1","first-page":"129","article-title":"Appendiceal malignancies","volume":"15","author":"Lyss","year":"1988","journal-title":"Semin Oncol"},{"key":"2022070819572062800_ref2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5009\/gnl.2010.4.3.351","article-title":"Secondary appendiceal tumors: a review of 139 cases","volume":"4","author":"Yoon","year":"2010","journal-title":"Gut Liver"},{"key":"2022070819572062800_ref3","doi-asserted-by":"crossref","first-page":"e920010","DOI":"10.12659\/AJCR.920010","article-title":"Missed gastric Cancer metastasis to the appendix: case report and literature review","volume":"21","author":"Alhadid","year":"2020","journal-title":"Am J Case Rep"},{"key":"2022070819572062800_ref4","first-page":"140","article-title":"Metastatic gastric signet-ring cell carcinoma: a rare cause of acute appendicitis","volume":"32","author":"Er\u00e7etin","year":"2015","journal-title":"Ulus Cerrahi Derg"},{"key":"2022070819572062800_ref5","doi-asserted-by":"crossref","first-page":"E17","DOI":"10.1055\/s-2006-944904","article-title":"Metastasis to the appendix from gastric cancer detected incidentally on colonoscopy","author":"Fu","year":"2007","journal-title":"Endoscopy"},{"key":"2022070819572062800_ref6","first-page":"153","article-title":"An unusual cause of acute appendicitis","volume":"39","author":"Gillesse","year":"1987","journal-title":"Neth J Surg"},{"key":"2022070819572062800_ref7","first-page":"137","article-title":"Acute suppurative appendicitis with perforation resulting from metastatic carcinoma; report of a case","volume":"29","author":"Goldfarb","year":"1951","journal-title":"Surgery"},{"key":"2022070819572062800_ref8","doi-asserted-by":"crossref","first-page":"rjy208","DOI":"10.1093\/jscr\/rjy208","article-title":"Acute appendicitis as the first presentation of appendiceal metastasis of gastric cancer-report of a rare case","volume":"2018","author":"Karanikas","year":"2018","journal-title":"J Surg Case Rep"},{"key":"2022070819572062800_ref9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1368-504X.2005.00360.x","article-title":"Recurrent gastric adenocarcinoma presenting as acute appendicitis: a case report","volume":"147","author":"Lin","year":"2005","journal-title":"Int J Clin Pract Suppl"},{"key":"2022070819572062800_ref10","first-page":"241","article-title":"Acute appendicitis as primary symptom of gastric cancer","volume":"73","author":"M\u00f8ller","year":"1984","journal-title":"Ann Chir Gynaecol"},{"key":"2022070819572062800_ref11","doi-asserted-by":"crossref","first-page":"rjt080","DOI":"10.1093\/jscr\/rjt080","article-title":"Incidental complete excision of appendiceal gastric cancer metastasis","volume":"2013","author":"Simpson","year":"2013","journal-title":"J Surg Case Rep"},{"key":"2022070819572062800_ref12","doi-asserted-by":"crossref","first-page":"7132","DOI":"10.21037\/apm-21-1098","article-title":"Acute appendicitis caused by metastatic gastric adenocarcinoma: a case report and literature review","volume":"10","author":"Wang","year":"2021","journal-title":"Ann Palliat Med"},{"key":"2022070819572062800_ref13","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00268-009-9985-6","article-title":"Investigation of the lymphatic stream of the stomach in gastric cancer with solitary lymph node metastasis","volume":"33","author":"Tokunaga","year":"2009","journal-title":"World J Surg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/7\/rjac322\/44643206\/rjac322.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/7\/rjac322\/44643206\/rjac322.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T19:57:41Z","timestamp":1657310261000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjac322\/6633858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjac322","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2022,7]]},"published":{"date-parts":[[2022,7,1]]},"article-number":"rjac322"}}