{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:40:34Z","timestamp":1787067634951,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malakoplakia is a rare entity on inflammatory base that mostly occurs in immunocompromised individuals which is thought to be secondary to a bactericidal defect in macrophages. The genitourinary tract is typically affected. The appendix is a very rare localization. We report a case of malakoplakia in the appendix of a young healthy patient with a recent history of abdominal pain associated with diarrhea and nausea. The colonscopy and CT scan showed an extramucosal bumping mass pressing on the cecum and covered by normal mucosa. The patient underwent to laparoscopic appendectomy. The histology showed a malakoplakia of the appendix. Gastrointestinal localization of malakoplakia is often associated with preexisting diseases, which are probably responsible for an immune disorder underlying the etiopathogenesis of the disease. However, in our case, the patient had no comorbidities. Probably, a clinically unknown immune predisposition plays an important role. Further studies are needed to clarify this nexus.<\/jats:p>","DOI":"10.1093\/jscr\/rjac357","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T15:29:51Z","timestamp":1659626991000},"source":"Crossref","is-referenced-by-count":6,"title":["Malakoplakia of the appendix in a young healthy adult: a case report and literature review"],"prefix":"10.1093","volume":"2022","author":[{"given":"Dario","family":"Pastena","sequence":"first","affiliation":[{"name":"Division of Abdominal Surgery , Department of Medical and Surgical Sciences, , Rome, Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Department of Medical and Surgical Sciences, , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-6861","authenticated-orcid":false,"given":"Mauro","family":"Giambusso","sequence":"additional","affiliation":[{"name":"Division of Abdominal Surgery , Department of Medical and Surgical Sciences, , Rome, Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Department of Medical and Surgical Sciences, , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Castri","sequence":"additional","affiliation":[{"name":"Division of General Pathological Anatomy , Department of Women's and Child Health and Public Health Sciences, , Rome, Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Department of Women's and Child Health and Public Health Sciences, , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo Eugenio","family":"Potenza","sequence":"additional","affiliation":[{"name":"Division of Abdominal Surgery , Department of Medical and Surgical Sciences, , Rome, Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Department of Medical and Surgical Sciences, , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Caprino","sequence":"additional","affiliation":[{"name":"Division of Abdominal Surgery , Department of Medical and Surgical Sciences, , Rome, Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Department of Medical and Surgical Sciences, , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Sacchetti","sequence":"additional","affiliation":[{"name":"Division of Abdominal Surgery , Department of Medical and Surgical Sciences, , Rome, Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Department of Medical and Surgical Sciences, , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Sofo","sequence":"additional","affiliation":[{"name":"Division of Abdominal Surgery , Department of Medical and Surgical Sciences, , Rome, Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Department of Medical and Surgical Sciences, , Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"2022080419294394700_ref1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00383-010-2551-3","article-title":"Pediatric malakoplakia of colon: a report of two cases","volume":"26","author":"Divya","year":"2010","journal-title":"Pediatr Surg Int"},{"key":"2022080419294394700_ref2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1046\/j.1464-410x.1999.00198.x","article-title":"Malacoplakia: von Hansemann's disease","volume":"84","author":"Dasgupta","year":"1999","journal-title":"BJU Int"},{"key":"2022080419294394700_ref3","first-page":"67","article-title":"Malakoplakia of the urinary system","volume":"59","author":"Ci\u0119szczyk","year":"2019","journal-title":"Folia Med Cracov"},{"key":"2022080419294394700_ref4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13000-020-01013-y","article-title":"Malakoplakia of the gastrointestinal tract: clinicopathologic analysis of 23 cases","volume":"15","author":"Lee","year":"2020","journal-title":"Diagn Pathol"},{"key":"2022080419294394700_ref5","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/PAS.0000000000001491","article-title":"Gastrointestinal malakoplakia: clinicopathologic analysis of 26 cases","volume":"44","author":"Yang","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"2022080419294394700_ref6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/pgmj.57.664.95","article-title":"Malakoplakia of the gastrointestinal tract","volume":"57","author":"McClure","year":"1981","journal-title":"Postgrad Med J"},{"key":"2022080419294394700_ref7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5858\/2008-132-113-CM","article-title":"Cutaneous malakoplakia","volume":"132","author":"Kohl","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"2022080419294394700_ref8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/ajcp\/53.2.284","article-title":"Malakoplakia of the appendix: a case report","volume":"53","author":"Blackshear","year":"1970","journal-title":"Am J Clin Pathol"},{"key":"2022080419294394700_ref9","first-page":"304","article-title":"Malacoplakia of the appendix","volume":"8","author":"Pandit","year":"1989","journal-title":"Indian J Gastroenterol"},{"key":"2022080419294394700_ref10","first-page":"465","article-title":"Malakoplakia of the appendix","volume":"52","author":"Borghesi","year":"1997","journal-title":"Minerva Chir"},{"key":"2022080419294394700_ref11","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.5858\/2000-124-1828-MOTA","article-title":"Malakoplakia of the appendix. An unusual association with eggs of Taenia species","volume":"124","author":"Jain","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"2022080419294394700_ref12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0090-4295(75)90727-X","article-title":"Sarcoidosis and malakoplakia","volume":"6","author":"Brownstein","year":"1975","journal-title":"Urology"},{"key":"2022080419294394700_ref13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/003130299105160","article-title":"Malakoplakia and tuberculosis","volume":"31","author":"Govender","year":"1999","journal-title":"Pathology"},{"key":"2022080419294394700_ref14","first-page":"664","article-title":"Colonic carcinoma associated with malakoplakia","volume":"63","author":"Edmund","year":"2014","journal-title":"West Indian Med J"},{"key":"2022080419294394700_ref15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/1752-1947-2-181","article-title":"Malakoplakia of the appendix, an uncommon entity at an unusual site: a case report","volume":"2","author":"Shaktawat","year":"2008","journal-title":"J Med Case Reports"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/8\/rjac357\/45249158\/rjac357.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/8\/rjac357\/45249158\/rjac357.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T15:30:06Z","timestamp":1659627006000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjac357\/6655635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjac357","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,4]]},"published":{"date-parts":[[2022,8,1]]},"article-number":"rjac357"}}