{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:22:33Z","timestamp":1768882953278,"version":"3.49.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs of the small bowel are rare, and often present with an abdominal mass and\/or bleeding. Chemotherapy and surgery are the mainstay of therapy. Here, we discuss an unusual case of a ruptured jejunal GIST with hemoperitoneum and recurrence despite surgical excision followed by Imatinib treatment. Forty-five cases of ruptured small intestinal GISTs were identified in the literature. Most cases were in males and were found to be at the site of the jejunum.<\/jats:p>","DOI":"10.1093\/jscr\/rjac434","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T23:19:44Z","timestamp":1669418384000},"source":"Crossref","is-referenced-by-count":4,"title":["Ruptured gastro-intestinal stromal tumor as a surgical emergency: A case report and literature review"],"prefix":"10.1093","volume":"2022","author":[{"given":"Mohamed","family":"Abdelgawad","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Texas Health Science Center, UT Health East Texas , Tyler, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar M","family":"Kamel","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, Tulane University , New Orleans, LA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5248-3142","authenticated-orcid":false,"given":"Peter P","family":"Issa","sequence":"additional","affiliation":[{"name":"School of Medicine, Louisiana State University Health Sciences Center , New Orleans, LA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, Tulane University , New Orleans, LA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-4280","authenticated-orcid":false,"given":"Lutfi","family":"Barghuthi","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Health Science Center, UT Health East Texas , Tyler, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Health Science Center, UT Health East Texas , Tyler, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hishaam","family":"Ismael","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Health Science Center, UT Health East Texas , Tyler, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"2022112523090608400_ref1","first-page":"49","article-title":"A ruptured Jejunal gastrointestinal stromal tumor with Hemoperitoneum mimicking ovarian carcinoma","volume":"13","author":"Hwang","year":"2020","journal-title":"Int J Clin Exp 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Res"},{"key":"2022112523090608400_ref8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ijsu.2014.02.004","article-title":"Gastrointestinal stromal tumors (GIST) related emergencies","volume":"12","author":"Sorour","year":"2014","journal-title":"Int J Surg"},{"key":"2022112523090608400_ref9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1245\/ASO.2004.09.011","article-title":"Surgery and Imatinib in the management of GIST: emerging approaches to adjuvant and neoadjuvant therapy","volume":"11","author":"Eisenberg","year":"2004","journal-title":"Ann Surg Oncol"},{"key":"2022112523090608400_ref10","first-page":"818","article-title":"Tumor resection following Imatinib pretreatment in GI stromal tumors","volume-title":"Proc Am Soc Clin Oncol","author":"Hohenberger","year":"2003"},{"key":"2022112523090608400_ref11","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1007\/s00535-002-1168-2","article-title":"Treatment with STI571, a tyrosine kinase 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Case report","volume":"15","author":"Efremidou","year":"2006","journal-title":"J Gastrointestin Liver Dis"},{"key":"2022112523090608400_ref15","first-page":"264","article-title":"Multifocal intestinal stromal tumors with jejunal perforation and intra-abdominal abscess: report of a case","volume":"19","author":"Karag\u00fclle","year":"2008","journal-title":"Turk J Gastroenterol"},{"key":"2022112523090608400_ref16","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.3748\/wjg.14.2928","article-title":"A ruptured large extraluminal ileal gastrointestinal stromal tumor causing hemoperitoneum","volume":"14","author":"Hirasaki","year":"2008","journal-title":"World J Gastroenterol: WJG"},{"key":"2022112523090608400_ref17","first-page":"69","article-title":"Acute abdomen for perforated gastrointestinal stromal tumor (GIST). 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Personal experience on three cases of the tumors of the small intestine complicated and emergency surgically treated","volume":"30","author":"Licursi","year":"2009","journal-title":"G Chir"},{"key":"2022112523090608400_ref20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.clinimag.2009.03.005","article-title":"Multiple gastrointestinal stromal tumors in a patient with type I neurofibromatosis presenting with tumor rupture and peritonitis","volume":"34","author":"Ku","year":"2010","journal-title":"Clin Imaging"},{"key":"2022112523090608400_ref21","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4318\/tjg.2010.0142","article-title":"A case of gastrointestinal stromal tumor presenting with small bowel perforation and internal hernia","volume":"21","author":"\u00d6zben","year":"2010","journal-title":"Turk J Gastroenterol"},{"key":"2022112523090608400_ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7819-8-95","article-title":"Malignant gastrointestinal stromal tumor presenting with hemoperitoneum in puerperium: report of a case with review of the literature","volume":"8","author":"Varras","year":"2010","journal-title":"World J Surg Oncol"},{"key":"2022112523090608400_ref23","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4318\/tjg.2011.0195","article-title":"A rare perforated gastrointestinal stromal tumor in the jejunum: a case report","volume":"22","author":"Feng","year":"2011","journal-title":"Turk J Gastroenterol"},{"key":"2022112523090608400_ref24","first-page":"44","article-title":"Perforated gastrointestinal stromal tumor of the small intestine: a case report presenting with peritonitis","volume":"1","author":"Paramythiotis","year":"2011","journal-title":"J Curr Surg"},{"key":"2022112523090608400_ref25","first-page":"463","article-title":"Giant Jejunal gastrointestinal stromal tumor presenting as acute abdomen","volume":"53","author":"Bhandarwar","year":"2011","journal-title":"Bombay Hosp J"},{"key":"2022112523090608400_ref26","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1016\/j.clinre.2011.08.004","article-title":"Tumor abscess formation caused by Morganella morganii complicated with Bacteremia in a patient with gastrointestinal stromal tumor","volume":"36","author":"Chen","year":"2012","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"2022112523090608400_ref27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4318\/tjg.2012.0329","article-title":"Gastrointestinal stromal tumor perforation in a case with Neurofibromatosis presenting with abdominal pain","volume":"23","author":"Aslan","year":"2012","journal-title":"Turk J Gastroenterol"},{"key":"2022112523090608400_ref28","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.3892\/ol.2012.917","article-title":"Perforated gastrointestinal stromal tumor in the jejunum: a rare cause of acute abdomen","volume":"4","author":"Memmi","year":"2012","journal-title":"Oncol Lett"},{"key":"2022112523090608400_ref29","article-title":"Jejunal gastrointestinal stromal tumor causing perforation peritonitis in a young male: a case report","volume":"2","author":"Choudhary","year":"2012","journal-title":"Int J Surg"},{"key":"2022112523090608400_ref30","first-page":"341","article-title":"A ruptured gastrointestinal stromal tumor of jejunum causing acute abdomen","volume":"3","author":"Sezer","year":"2012","journal-title":"J Clin Anal Med"},{"key":"2022112523090608400_ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1749-7922-7-37","article-title":"Spontaneous perforation of jejunal gastrintestinal stromal tumour (Gist). 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a literature review","volume":"6","author":"Alessiani","year":"2015","journal-title":"Int J Surg Case Rep"},{"key":"2022112523090608400_ref38","first-page":"99","article-title":"Spontaneous rupture of extraluminal jejunal gastrointestinal stromal tumor causing acute abdomen and hemoperitoneum","volume":"31","author":"Attaallah","year":"2015","journal-title":"Turk J Surg\/Ulus Cerrahi Derg"},{"key":"2022112523090608400_ref39","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s10140-015-1312-y","article-title":"BWH emergency radiology\u2014surgical correlation: small-bowel GI stromal tumor perforation","volume":"22","author":"Cabral","year":"2015","journal-title":"Emerg Radiol"},{"key":"2022112523090608400_ref40","doi-asserted-by":"crossref","DOI":"10.4103\/amhs.amhs_306_21","article-title":"Gastrointestinal stromal tumor of jejunum presenting as a pelvic mass: a rare case report and review of literature","volume-title":"Arch Med Health 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