{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:37:29Z","timestamp":1793407049821,"version":"4.5.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Squamous cell carcinoma (SCC) arising in a Zenker diverticulum (ZD) is an extremely rare entity. Approximately 50 cases have been reported worldwide. We report a case of a 74-year-old man who presented to our institution with chronic regurgitation, dysphagia and halitosis. The patient was initially seen in 2015 at which point he reported a 10-year history of these symptoms and was diagnosed with ZD. A barium swallow was done revealing a large posterior esophageal diverticulum with significant residual contrast within the diverticulum lumen. Given these findings, he was taken for open surgical excision where a SCC was identified. Although it is extremely rare for a SCC to occur in a ZD, patients with ZD must undergo regular surveillance endoscopy of the esophagus and the diverticulum itself to identify any suspicious mass or lesion arising in within.<\/jats:p>","DOI":"10.1093\/jscr\/rjac458","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T21:31:02Z","timestamp":1664487062000},"source":"Crossref","is-referenced-by-count":6,"title":["Squamous cell carcinoma arising in a Zenker diverticulum"],"prefix":"10.1093","volume":"2022","author":[{"given":"Francesca","family":"Polit","sequence":"first","affiliation":[{"name":"Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center , Miami Beach, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3799-2595","authenticated-orcid":false,"given":"Hisham F","family":"Bahmad","sequence":"additional","affiliation":[{"name":"Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center , Miami Beach, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Wahi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Mount Sinai Medical Center , Miami Beach, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunima","family":"Deb","sequence":"additional","affiliation":[{"name":"Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center , Miami Beach, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Newsome","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University , Miami, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Howard","sequence":"additional","affiliation":[{"name":"Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center , Miami Beach, FL , USA"},{"name":"Department of Translational Medicine, Herbert Wertheim College of Medicine , Florida International University, Miami, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Poppiti","sequence":"additional","affiliation":[{"name":"Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center , Miami Beach, FL , USA"},{"name":"Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University , Miami, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kfir","family":"Ben-David","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Mount Sinai Medical Center , Miami Beach, FL , USA"},{"name":"Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University , Miami, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center , Miami Beach, FL , USA"},{"name":"Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University , Miami, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"2022092921305111500_ref1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/MOO.0000000000000309","article-title":"Pharyngoesophageal diverticuli: diagnosis, incidence and management","volume":"24","author":"Little","year":"2016","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"2022092921305111500_ref2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0003-4975(10)62238-2","article-title":"Long-term survival following diverticulectomy for cancer in pharyngoesophageal (Zenker's) diverticulum","volume":"38","author":"Huang","year":"1984","journal-title":"Ann Thorac Surg"},{"key":"2022092921305111500_ref3","first-page":"976","article-title":"Carcinoma occurring in pharyngoesophageal diverticulum: report of three cases","volume":"66","author":"Wychulis","year":"1969","journal-title":"Surgery"},{"key":"2022092921305111500_ref4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1177\/000348949910801102","article-title":"Pharyngeal pouch carcinoma: real or imaginary risks?","volume":"108","author":"Bradley","year":"1999","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"2022092921305111500_ref5","first-page":"284","article-title":"Zenker's diverticulum: aetiopathogenesis, symptoms and diagnosis. Comparison of operative methods","volume":"8","author":"Nehring","year":"2013","journal-title":"Prz Gastroenterol"},{"key":"2022092921305111500_ref6","volume-title":"Handbuch der Krankheiten des Chylopo\u00ebtischen Apparates I.: Krankheiten des Oesophagus","author":"Zenker","year":"1877"},{"key":"2022092921305111500_ref7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s12876-021-01914-2","article-title":"Zenker\u2019s diverticulum in an 85-year-old Ugandan man","volume":"21","author":"Sereke","year":"2021","journal-title":"BMC Gastroenterol"},{"key":"2022092921305111500_ref8","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.ejrad.2010.05.028","article-title":"Sonographic diagnosis features of Zenker diverticulum","volume":"80","author":"Lixin","year":"2011","journal-title":"Eur J Radiol"},{"key":"2022092921305111500_ref9","first-page":"219","article-title":"Zenker's diverticulum: exploring treatment options","volume":"33","author":"Bizzotto","year":"2013","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"2022092921305111500_ref10","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/pmj.77.910.506","article-title":"Pharyngeal pouch (Zenker's diverticulum)","volume":"77","author":"Siddiq","year":"2001","journal-title":"Postgrad Med J"},{"key":"2022092921305111500_ref11","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ijscr.2012.07.010","article-title":"Squamous cell carcinoma in an esophageal diverticulum below the aortic arch","volume":"3","author":"Wakita","year":"2012","journal-title":"Int J Surg Case Rep"},{"key":"2022092921305111500_ref12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00000658-190402000-00003","article-title":"Diverticula of the oesophagus, with the report of a case","volume":"39","author":"Halstead","year":"1904","journal-title":"Ann Surg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/9\/rjac458\/46125016\/rjac458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/9\/rjac458\/46125016\/rjac458.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T21:31:20Z","timestamp":1664487080000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjac458\/6726002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjac458","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9]]},"published":{"date-parts":[[2022,9,1]]},"article-number":"rjac458"}}