{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:13:24Z","timestamp":1769505204503,"version":"3.49.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The solid pseudopapillary neoplasm (SPN) of the pancreas is an uncommon, low-grade malignant tumour, mostly seen in young women. We report a rare case of a 44-year-old female who presented with spontaneous rupture and upper gastrointestinal bleeding. The emergency endoscopy revealed a 2\u00a0cm bleeding ulcer on the duodenal bulb. A computer tomography scan (CT scan) showed a 6.7\u00a0cm mass, with solid and cystic components arising in the head of the pancreas. After achieving haemostasis, she was discharged. Two months later, a new CT scan showed a persistent 6\u00a0cm mass in the head of the pancreas, now containing air and communicating with the duodenal lumen. The patient was successfully treated by pancreatoduodenectomy. Histopathological examination showed a T3N0M0 SPN with immunohistochemical expression of \u03b2-catenin, synaptophysin, vimentin and progesterone receptor, and negativity for chromogranin. The labelling index of Ki 67 was 2%. No recurrence was present after 2\u00a0years of follow-up.<\/jats:p>","DOI":"10.1093\/jscr\/rjac462","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T23:36:33Z","timestamp":1665444993000},"source":"Crossref","is-referenced-by-count":5,"title":["Spontaneous rupture and upper gastrointestinal bleeding of solid pseudopapillary neoplasm of the pancreas"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8316-9703","authenticated-orcid":false,"given":"Fernando","family":"Revoredo","sequence":"first","affiliation":[{"name":"Department of General Surgery, Cl\u00ednica Internacional , Lima, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz","family":"Kometter","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Cl\u00ednica Internacional , Lima, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Cl\u00ednica Internacional , Lima, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Cl\u00ednica Internacional , Lima, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Luna","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Cl\u00ednica Internacional , Lima, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Valdes","sequence":"additional","affiliation":[{"name":"Division of Pathology, Cl\u00ednica Internacional - Instituto de Patolog\u00eda y Biolog\u00eda Molecular Arias Stella , Lima, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"2022101023362537200_ref1","first-page":"340","volume-title":"WHO Classification of Tumours. 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