{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:17:38Z","timestamp":1778890658615,"version":"3.51.4"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tumor-induced osteomalacia (TIO) is a rare tumor-associated syndrome in which osteomalacia is induced by a tumor. A 67-year-old male patient presented for the first time with low back pain, weakness of the lower extremities and difficulty in walking. Six years earlier, he had nonspecific symptoms such as low back pain, and blood tests showed high alkaline phosphatase and low phosphorus. In addition, fibroblast growth factor 23 (FGF23) was abnormally high at 454 pg\/mL. A diagnosis of FGF23-related hypophosphatemic osteomalacia was made. Somatostatin receptor scintigraphy, venous sampling and MRI were performed to localize and diagnose TIO. The tumor was found to be confined to the right femoral head and hemiarthroplasty was performed. Pathological examination revealed a phosphaturic mesenchymal tumor. Postoperatively, symptoms and blood test data improved. Although resection of the lesion and osteochondral transplantation or total hip arthroplasty were considered, hemiarthroplasty was chosen over concerns about treatment failure due to seeding.<\/jats:p>","DOI":"10.1093\/jscr\/rjac478","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T23:41:00Z","timestamp":1672184460000},"source":"Crossref","is-referenced-by-count":3,"title":["Hemiarthroplasty for tumor-induced osteomalacia caused by tumor localized in femoral head: a case report"],"prefix":"10.1093","volume":"2022","author":[{"given":"Sayaka","family":"Arita","sequence":"first","affiliation":[{"name":"University of Tsukuba College of Medicine, School of Medicine and Health Sciences, , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-4900","authenticated-orcid":false,"given":"Tomofumi","family":"Nishino","sequence":"additional","affiliation":[{"name":"University of Tsukuba Department of Orthopaedic Surgery, Faculty of Medicine, , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuuki","family":"Mitani","sequence":"additional","affiliation":[{"name":"University of Tsukuba Department of Orthopaedic Surgery, Faculty of Medicine, , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Sakashita","sequence":"additional","affiliation":[{"name":"University of Tsukuba Department of Orthopaedic Surgery, Faculty of Medicine, , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Totsuka","sequence":"additional","affiliation":[{"name":"University of Tsukuba Department of Orthopaedic Surgery, Faculty of Medicine, , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryunosuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"University of Tsukuba Department of Orthopaedic Surgery, Faculty of Medicine, , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Mishima","sequence":"additional","affiliation":[{"name":"University of Tsukuba Department of Orthopaedic Surgery, Faculty of Medicine, , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Kawai","sequence":"additional","affiliation":[{"name":"University of Tsukuba Department of Diagnostic Pathology, Faculty of Medicine, , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Matsubara","sequence":"additional","affiliation":[{"name":"University of Tsukuba Department of Diagnostic Pathology, Faculty of Medicine, , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshionao","family":"Oda","sequence":"additional","affiliation":[{"name":"Kyushu University Department of Anatomic Pathology, Graduate School of Medical Sciences, , Fukuoka, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"University of Tsukuba Department of Orthopaedic Surgery, Faculty of Medicine, , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"2022122723405057000_ref1","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1001\/jama.294.10.1260","article-title":"Tumor-induced osteomalacia","volume":"294","author":"Jan de Beur","year":"2005","journal-title":"JAMA"},{"key":"2022122723405057000_ref2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis","volume":"19","author":"Shimada","year":"2004","journal-title":"J Bone Miner 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