{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:20:06Z","timestamp":1754482806563,"version":"3.41.2"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The diagnosis of intra-abdominal infection and post-operative peritonitis based on clinical examination, biomarkers and radiological signs, should be made as early as possible to improve outcomes and decrease mortality through early and optimal source control, adequate surgery and appropriate antibiotic therapy (Montravers et\u00a0al. Therapeutic management of peritonitis: a comprehensive guide for intensivists. Intensive Care Med 2016;42:1234\u201347). However, the indication and the timing of the surgery is often not an easy decision. This case presents the use of a novel early biomarker of infection and sepsis, pancreatic stone protein (Fidalgo et\u00a0al. Pancreatic stone protein: review of a new biomarker in sepsis. J Clin Med 2022;11:1085), as a tool to aid in the diagnosis of intra-abdominal infection and post-operative peritonitis and to help guide the decision for adequate surgeries in a patient with intra-abdominal infection and post radical prostatectomy peritonitis.<\/jats:p>","DOI":"10.1093\/jscr\/rjac497","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T05:41:50Z","timestamp":1672206110000},"source":"Crossref","is-referenced-by-count":3,"title":["Pancreatic stone protein as a biomarker for the early diagnosis of post-operative peritonitis, intra-abdominal infection and sepsis"],"prefix":"10.1093","volume":"2022","author":[{"given":"Fran\u00e7ois","family":"Ventura","sequence":"first","affiliation":[{"name":"Hirslanden Clinique des Grangettes Division of Critical Care Medicine, , Geneva, Switzerland"},{"name":"University Hospitals of Geneva Division of Anesthesiology, , Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvan","family":"Gasche","sequence":"additional","affiliation":[{"name":"Hirslanden Clinique des Grangettes Division of Critical Care Medicine, , Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aymen Kraiem Ben","family":"Rached","sequence":"additional","affiliation":[{"name":"Hirslanden Clinique des Grangettes Division of Critical Care Medicine, , Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9borah","family":"Pugin","sequence":"additional","affiliation":[{"name":"Hirslanden Clinique des Grangettes Division of Critical Care Medicine, , Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Mollard","sequence":"additional","affiliation":[{"name":"Hirslanden Clinique des Grangettes Division of Critical Care Medicine, , Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Vora","sequence":"additional","affiliation":[{"name":"Hirslanden Clinique des Grangettes Division of Infectiology, , Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Charbonnet","sequence":"additional","affiliation":[{"name":"Hirslanden Clinique des Grangettes Division of Surgery, , Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9o","family":"B\u00fchler","sequence":"additional","affiliation":[{"name":"Hirslanden Clinique des Grangettes Division of Surgery, , Geneva, Switzerland"},{"name":"University of Fribourg Surgical Research Unit, , Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"2022122805414253400_ref1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1007\/s00134-016-4307-6","article-title":"Therapeutic management of peritonitis: a comprehensive guide for intensivists","volume":"42","author":"Montravers","year":"2016","journal-title":"Intensive Care Med"},{"key":"2022122805414253400_ref3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00134-019-05841-5","article-title":"Post-operative abdominal infections: epidemiology, operational definitions, and outcomes","volume":"46","author":"Bassetti","year":"2020","journal-title":"Intensive Care Med"},{"key":"2022122805414253400_ref4","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00134-019-05819-3","article-title":"Epidemiology of intra-abdominal infection and sepsis in critically ill patients: \u201cAbSeS\u201d, a multinational observational cohort study and ESICM Trials Group Project","volume":"45","author":"Blot","year":"2019","journal-title":"Intensive Care Med"},{"key":"2022122805414253400_ref5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13054-021-03576-8","article-title":"Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study","volume":"25","author":"Pugin","year":"2021","journal-title":"Crit Care"},{"key":"2022122805414253400_ref6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13017-021-00387-8","article-title":"WSES\/GAIS\/SIS-E\/WSIS\/AAST global clinical pathways for patients with intra-abdominal infections","volume":"16","author":"Sartelli","year":"2021","journal-title":"World J Emerg Surg"},{"key":"2022122805414253400_ref7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1586\/eri.11.164","article-title":"Serum procalcitonin in the diagnosis and management of intra-abdominal infections","volume":"10","author":"Watkins","year":"2012","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2022122805414253400_ref2","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3390\/jcm11041085","article-title":"Pancreatic stone protein: review of a new biomarker in sepsis","volume":"11","author":"Fidalgo","year":"2022","journal-title":"J Clin Med"},{"key":"2022122805414253400_ref8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13054-021-03609-2","article-title":"Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis","volume":"25","author":"Prazak","year":"2021","journal-title":"Crit Care"},{"key":"2022122805414253400_ref9","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/CCM.0b013e3182771193","article-title":"Pancreatic stone protein predicts outcome in patients with peritonitis in the 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