{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:48:05Z","timestamp":1780404485024,"version":"3.54.1"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignant peritoneal mesothelioma is a rare cancer originating primarily from the peritoneum with a poor prognosis and non-specific clinical presentation. We present a case of a 60-year-old male, retired metallurgy engineer who initially presented with shortness of breath, lethargy, weight loss, vague abdominal pain and night sweats. Extensive workup for almost 2 months finally leads to the diagnosis of primary malignant peritoneal mesothelioma based on immunohistochemical analysis of loss of BAP1 gene. The patient was deemed non-suitable for surgical management and started on palliative carboplatin and pemetrexed. In conclusion, histological diagnosis is essential for peritoneal diseases before considering it as a metastasis from other primary tumours. Furthermore, immunohistochemical analysis and genetic profiling may also guide towards the diagnosis and possible treatment.<\/jats:p>","DOI":"10.1093\/jscr\/rjac555","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T21:23:42Z","timestamp":1670534622000},"source":"Crossref","is-referenced-by-count":4,"title":["Malignant peritoneal mesothelioma\u2014a diagnostic challenge"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9165-1647","authenticated-orcid":false,"given":"Saad","family":"Abdul Razzak","sequence":"first","affiliation":[{"name":"General Surgery Department, St. Luke\u2019s General Hospital , Kilkenny , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Awan","sequence":"additional","affiliation":[{"name":"St Luke\u2019s General Hospital , Kilkenny , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Ahmed","sequence":"additional","affiliation":[{"name":"General Surgery Department, St. Luke\u2019s General Hospital , Kilkenny , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"2022120821232363000_ref1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4149\/neo_2014_053","article-title":"Prognostic factors influencing survival in 35 patients with malignant peritoneal mesothelioma","volume":"61","author":"Kaya","year":"2014","journal-title":"Neoplasma"},{"key":"2022120821232363000_ref2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/(SICI)1096-9098(199901)70:1<6::AID-JSO2>3.0.CO;2-X","article-title":"Clinical picture, response to therapy, and survival of women with diffuse malignant peritoneal mesothelioma","volume":"70","author":"Eltabbakh","year":"1999","journal-title":"J Surg Oncol"},{"key":"2022120821232363000_ref3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/carcin\/bgu227","article-title":"Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival","volume":"36","author":"Baumann","year":"2015","journal-title":"Carcinogenesis"},{"key":"2022120821232363000_ref4","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1200\/JCO.2018.79.0352","article-title":"A subset of mesotheliomas with improved survival occurring in carriers of BAP1 and other germline mutations","volume":"36","author":"Pastorino","year":"2018","journal-title":"J Clin Oncol"},{"key":"2022120821232363000_ref5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3322\/caac.21572","article-title":"Mesothelioma: scientific clues for prevention, diagnosis, and therapy","volume":"69","author":"Carbone","year":"2019","journal-title":"CA Cancer J Clin"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/12\/rjac555\/47708019\/rjac555.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2022\/12\/rjac555\/47708019\/rjac555.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T21:23:45Z","timestamp":1670534625000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjac555\/6881623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":5,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjac555","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12]]},"published":{"date-parts":[[2022,12,1]]},"article-number":"rjac555"}}