{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:28Z","timestamp":1753877188973,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malignant melanomas are aggressive cancers that can prove to be fatal, with Australia harbouring the highest incidence of skin cancers worldwide. Surprisingly, as little as 13.4% of patients undergoing surgical resection of high-risk melanomas remain disease-free after 2 years, with 31.6% showing evidence of distant spread. Although rare, secondary tumours of the ampulla of Vater have been documented, with the most common primaries involving breast, renal and melanoma cancers. We report the case of a malignant melanoma of the ampulla of Vater occurring in a patient 4-year post-surgical resection of a Stage II melanoma manifesting as acute pancreatitis with obstructive jaundice. Given the rarity of secondary ampullary tumours, metastatic melanoma should always be considered in patients with obstructive jaundice and a history of melanoma resection. In the absence of distant disease, surgery may be considered after consensus at multidisciplinary team meetings and after consideration of the patient preference.<\/jats:p>","DOI":"10.1093\/jscr\/rjac621","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T18:32:17Z","timestamp":1674066737000},"source":"Crossref","is-referenced-by-count":2,"title":["The ampulla of Vater: A potential target for metastatic melanoma?"],"prefix":"10.1093","volume":"2023","author":[{"given":"David","family":"Armany","sequence":"first","affiliation":[{"name":"General Surgery Department, Nepean Hospital, NBMLHD , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preet","family":"Gosal","sequence":"additional","affiliation":[{"name":"General Surgery Department, Nepean Hospital, NBMLHD , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology , NSW Health Pathology, , NSW , Australia"},{"name":"Nepean Hospital, NBMLHD , NSW Health Pathology, , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"volume-title":"Melanoma Facts and Statistics 2022","author":"Melanoma Institute Australia","key":"2023011818315149300_ref1"},{"key":"2023011818315149300_ref2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10585-012-9521-1","article-title":"Progression of cutaneous melanoma: implications for treatment","volume":"29","author":"Leong","year":"2012","journal-title":"Clin Exp Metastasis"},{"key":"2023011818315149300_ref3","first-page":"163","article-title":"Melanoma development: current knowledge on melanoma pathogenesis","volume":"28","author":"Vukovi\u0107","year":"2020","journal-title":"Acta Dermatovenerol Croat"},{"key":"2023011818315149300_ref4","first-page":"274","article-title":"Secondary tumours of the ampulla of Vater: case report and review of the literature","volume":"8","author":"Sarocchi","year":"2018","journal-title":"Molecular and clinical oncology"},{"key":"2023011818315149300_ref5","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archsurg.1964.01310240065013","article-title":"Metastatic melanoma of the gastrointestinal tract","volume":"88","author":"Gupta","year":"1964","journal-title":"Arch Surg"},{"key":"2023011818315149300_ref6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/cncr.11513","article-title":"Symptoms and signs of primary melanoma: important indicators of Breslow depth","volume":"98","author":"Negin","year":"2003","journal-title":"Cancer"},{"key":"2023011818315149300_ref7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1001\/jamadermatol.2019.0440","article-title":"Risk of melanoma recurrence after diagnosis of a high-risk primary tumor","volume":"155","author":"Von Schuckmann","year":"2019","journal-title":"JAMA Dermatol"},{"key":"2023011818315149300_ref8","article-title":"The role for close follow-up of melanoma patients with AJCC stage I-III: a preliminary analysis","volume":"14","author":"Jillella","year":"1995","journal-title":"Proc Am Soc Clin Oncol"},{"volume-title":"Cancer Council Australia Clinical Guidelines: Follow Up After Initial Definitive Treatment for Each Stage of Melanoma.","key":"2023011818315149300_ref9"},{"key":"2023011818315149300_ref10","first-page":"1174","article-title":"Pancreaticoduodenectomy for melanoma metastatic to the duodenum: a case report and review of the literature","volume":"64","author":"Meyers","year":"1998","journal-title":"Am Surg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/1\/rjac621\/48756563\/rjac621.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/1\/rjac621\/48756563\/rjac621.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T18:32:29Z","timestamp":1674066749000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjac621\/6991136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjac621","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2023,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"rjac621"}}