{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:29Z","timestamp":1753877189075,"version":"3.41.2"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Prostate adenocarcinoma metastasizes to bone and forms fragile blastic lesions, which can present as dense obstacles intraoperatively. There are limited reports on the challenges surgeons face when operating through these lesions. A 60-year-old male with a pathologic subtrochanteric femur fracture in the presence of blastic lesions was successfully treated with intramedullary (IM) fixation. Pathologic fractures from blastic bone lesions are expected to increase in prevalence as survivability improves for metastatic prostate cancer. Orthopedic surgeons, when performing IM fixation for these fractures, should be prepared to utilize accessory equipment and should adopt creative techniques for reduction and fixation.<\/jats:p>","DOI":"10.1093\/jscr\/rjac630","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T04:03:33Z","timestamp":1674014613000},"source":"Crossref","is-referenced-by-count":0,"title":["Operative challenges of intramedullary nailing for subtrochanteric blastic pathological femur fracture: a case report"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4967-7859","authenticated-orcid":false,"given":"Kyle J","family":"Klahs","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Texas Tech University Health Sciences Center , El Paso TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Heh","sequence":"additional","affiliation":[{"name":"El Paso Paul Foster School of Medicine, Texas Tech University Health Sciences Center , El Paso TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Yousaf","sequence":"additional","affiliation":[{"name":"El Paso Paul Foster School of Medicine, Texas Tech University Health Sciences Center , El Paso TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Tadlock","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Texas Tech University Health Sciences Center , El Paso TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M","family":"Thabet","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Texas Tech University Health Sciences Center , El Paso TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"2023011718291226000_ref1","first-page":"321","article-title":"Bone metastases: an overview","volume":"11","author":"Macedo","year":"2017","journal-title":"Oncol Rev"},{"key":"2023011718291226000_ref2","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/pros.20574","article-title":"Prostate-specific antigen stimulates osteoprotegerin production and inhibits receptor activator of nuclear factor-kappaB ligand expression by human osteoblasts","volume":"67","author":"Yonou","year":"2007","journal-title":"Prostate"},{"key":"2023011718291226000_ref3","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.3390\/ijms20102587","article-title":"Prostate cancer and bone metastases: the underlying mechanisms","volume":"20","author":"Wong","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2023011718291226000_ref4","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1002\/jbmr.405","article-title":"Fracture risk in men with prostate cancer: a population-based study","volume":"26","author":"Melton","year":"2011","journal-title":"J Bone Miner Res"},{"key":"2023011718291226000_ref5","first-page":"803","article-title":"Intramedullary versus extramedullary fixation in the management of subtrochanteric femur fractures: a meta-analysis","volume":"10","author":"Liu","year":"2015","journal-title":"Clin Interv Aging"},{"key":"2023011718291226000_ref6","first-page":"190","article-title":"Clinical outcomes of intramedullary and extramedullary fixation in unstable intertrochanteric fractures: a randomized clinical trial","volume":"8","author":"Andalib","year":"2020","journal-title":"Arch Bone Jt Surg"},{"key":"2023011718291226000_ref7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s10555-006-9034-y","article-title":"The central role of osteoblasts in the metastasis of prostate cancer","volume":"25","author":"Choueiri","year":"2006","journal-title":"Cancer Metastasis Rev"},{"key":"2023011718291226000_ref8","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3332\/ecancer.2016.698","article-title":"The current status of prophylactic femoral intramedullary nailing for metastatic cancer","volume":"10","author":"Ormsby","year":"2016","journal-title":"Ecancermedicalscience"},{"key":"2023011718291226000_ref9","first-page":"256","article-title":"Metastatic disease in long bones. 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