{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:16:52Z","timestamp":1793117812908,"version":"4.5.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A perforated peptic or duodenal ulcer may cause an unusual expression of right lower quadrant pain. In Valentino\u2019s syndrome, the chemical fluid from the ulcer flows via the right paracolic gutter to the right iliac fossa, causing peritoneal irritation and chemical appendicitis which will mimic pain in the right lower quadrant. We report a case of a 23-year-old male patient who presented with cramping lower abdominal pain with fevers and vomiting. His pain was mostly in the right lower quadrant and radiated to his back. A perforation-related pneumoperitoneum was found on a computed tomography scan, along with an accumulation of fluid in the abdomen and thickening of the pyloric antrum. Valentino\u2019s syndrome\u2019s aberrant clinical picture mimicking acute appendicitis is a pathognomonic presentation of the disease. Right lower abdominal pain should also prompt the scrutiny of atypical differentials, such as perforated ulcers. Physicians need to manage these patients with a high index of suspicion.<\/jats:p>","DOI":"10.1093\/jscr\/rjad035","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T16:11:59Z","timestamp":1674058319000},"source":"Crossref","is-referenced-by-count":8,"title":["Valentino\u2019s syndrome: a bizarre clinical presentation"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-431X","authenticated-orcid":false,"given":"Dennis","family":"Machaku","sequence":"first","affiliation":[{"name":"Kilimanjaro Christian Medical Center General Surgery, , Kilimanjaro, Tanzania"},{"name":"Kilimanjaro Christian Medical University College , Kilimanjaro, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mujaheed","family":"Suleman","sequence":"additional","affiliation":[{"name":"Kilimanjaro Christian Medical Center General Surgery, , Kilimanjaro, Tanzania"},{"name":"Kilimanjaro Christian Medical University College , Kilimanjaro, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Mduma","sequence":"additional","affiliation":[{"name":"Kilimanjaro Christian Medical Center General Surgery, , Kilimanjaro, Tanzania"},{"name":"Kilimanjaro Christian Medical University College , Kilimanjaro, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mugisha","family":"Nkoronko","sequence":"additional","affiliation":[{"name":"Kilimanjaro Christian Medical Center General Surgery, , Kilimanjaro, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"2023020701021087500_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13017-020-00306-3","article-title":"Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines","volume":"15","author":"Di Saverio","year":"2020","journal-title":"World J Emerg Surg"},{"key":"2023020701021087500_ref2","article-title":"An unusual cause of abdominal pain: Valentino\u2019s syndrome. A case report","volume":"V4","author":"Lopez-Casillas","journal-title":"JPN J Gastroenterol Hepatol"},{"key":"2023020701021087500_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12659\/AJCR.922647","article-title":"Valentino\u2019s syndrome (with retroperitoneal ulcer perforation): a rare clinico-anatomical entity","volume":"21","author":"Noussios","year":"2020","journal-title":"Am J Case Rep"},{"key":"2023020701021087500_ref4","doi-asserted-by":"crossref","first-page":"bcr2014204716","DOI":"10.1136\/bcr-2014-204716","article-title":"Atypical presentation of perforated peptic ulcer disease in a 12-year-old boy","volume":"2014","author":"Mbarushimana","year":"2014","journal-title":"BMJ Case Rep"},{"key":"2023020701021087500_ref5","doi-asserted-by":"crossref","first-page":"540","DOI":"10.9738\/INTSURG-D-17-00136.1","article-title":"A case of valentino\u2019s syndrome presenting as possible appendicitis","volume":"104","author":"Cherry","year":"2019","journal-title":"Int Surg"},{"key":"2023020701021087500_ref6","first-page":"2","article-title":"A cautionary tale: unveiling Valentino\u2019s syndrome","volume":"14","author":"Mahajan","year":"2022","journal-title":"Cureus"},{"key":"2023020701021087500_ref7","doi-asserted-by":"crossref","first-page":"bcr0320126015","DOI":"10.1136\/bcr.03.2012.6015","article-title":"Valentino\u2019s syndrome a perforated peptic ulcer mimicking acute appendicitis","volume":"2012","author":"Wijegoonewardene","year":"2012","journal-title":"BMJ Case Rep"},{"key":"2023020701021087500_ref8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ajem.2004.04.037","article-title":"A pregnant woman presenting to the ED with Valentino's syndrome","volume":"23","author":"Hsu","year":"2005","journal-title":"Am J Emerg Med"},{"key":"2023020701021087500_ref9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/2156-7514.133263","article-title":"First report of preoperative imaging diagnosis of a surgically confirmed case of Valentino\u2019s syndrome","volume":"4","author":"Mahajan","year":"2014","journal-title":"J Clin Imaging Sci"},{"key":"2023020701021087500_ref10","doi-asserted-by":"crossref","first-page":"2050313X2211320","DOI":"10.1177\/2050313X221132069","article-title":"Valentino\u2019s syndrome: a rare and lethal differential diagnosis for acute appendicitis","volume":"10","author":"Rodrigo","year":"2022","journal-title":"SAGE Open Med Case Rep"},{"key":"2023020701021087500_ref11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/ts.ts_16_17","article-title":"Valentino\u2019s syndrome: an unusual presentation of a perforated peptic ulcer","volume":"2","author":"Sgro","year":"2017","journal-title":"Transl Surg"},{"key":"2023020701021087500_ref12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4103\/ais.ais_41_17","article-title":"Surgeons beware: it may not be acute appendicitis","volume":"7","author":"Iloh","year":"2017","journal-title":"Arch Int Surg"},{"key":"2023020701021087500_ref13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000264653","article-title":"Perforated peptic ulcer disease: a review of history and treatment","volume":"27","author":"Bertleff","year":"2010","journal-title":"Dig Surg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/2\/rjad035\/49103112\/rjad035.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/2\/rjad035\/49103112\/rjad035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T20:07:08Z","timestamp":1675714028000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjad035\/7028679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjad035","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2]]},"published":{"date-parts":[[2023,2,1]]},"article-number":"rjad035"}}