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The patient\u2019s initial imaging revealed a 4.6-cm irregular mass at 11:00 categorized as a BI-RADS 5 as well as an enlarged axillary lymph node and an area of 2.5\u00a0cm of heterogeneous calcifications in the 3 o\u2019clock position. The 4.6-cm lesion was revealed to be infiltrating ductal carcinoma with a squamous component, mixed metaplastic carcinoma, which was strongly ER (100+)\/PR (100+) positive, HER-2\/Neu negative on FISH. The 2.5-cm calcifications were ductal carcinoma in situ. The patient completed neoadjuvant chemotherapy, and had an excellent response. After further discussion, the patient elected for breast conservation therapy and underwent a left wireless localized partial mastectomy with a left axillary dissection. Surgical pathology revealed a near complete pathologic response with only 8-mm residual tumour as well as a negative conversion of the clipped axillary node.<\/jats:p>","DOI":"10.1093\/jscr\/rjad144","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:43:45Z","timestamp":1678841025000},"source":"Crossref","is-referenced-by-count":3,"title":["Mixed metaplastic carcinoma of the breast: a case report"],"prefix":"10.1093","volume":"2023","author":[{"given":"Amelia","family":"Tower","sequence":"first","affiliation":[{"name":"Texas Health Breast Specialists, Texas Health Harris Methodist Hospital , Fort Worth, TX 76104 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Hughes","sequence":"additional","affiliation":[{"name":"Texas Health Harris Methodist Hospital , Fort Worth, TX 76104 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Moore","sequence":"additional","affiliation":[{"name":"Anne Burnett Marion School of Medicine at Texas Christian University , Fort Worth, TX 76129 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2502-7480","authenticated-orcid":false,"given":"Kumaraman","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Anne Burnett Marion School of Medicine at Texas Christian University , Fort Worth, TX 76129 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"2023031500161108100_","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13058-020-01353-z","article-title":"Comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations","volume":"22","author":"Reddy","year":"2020","journal-title":"Breast Cancer Res"},{"key":"2023031500161108100_","first-page":"e28551","article-title":"Metaplastic breast cancer: characteristics and survival outcomes","volume":"14","author":"Thapa","year":"2022","journal-title":"Cureus"},{"key":"2023031500161108100_","article-title":"Clinicopathologic features of metaplastic breast carcinoma: experience from a tertiary cancer center of North India","volume":"14","author":"Damera","year":"2022","journal-title":"Cureus"},{"key":"2023031500161108100_","doi-asserted-by":"crossref","first-page":"e2341","DOI":"10.1097\/MD.0000000000002341","article-title":"Metaplastic breast carcinoma versus triple-negative breast cancer","volume":"94","author":"Aydiner","year":"2015","journal-title":"Medicine"},{"key":"2023031500161108100_","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jclinpath-2011-200586","article-title":"Metaplastic breast cancer: clinicopathological features and its prognosis","volume":"65","author":"Lee","year":"2012","journal-title":"J Clin Pathol"},{"key":"2023031500161108100_","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10549-011-1686-9","article-title":"Lack of efficacy to systemic chemotherapy for treatment of metaplastic carcinoma of the breast in the modern era","volume":"130","author":"Chen","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"2023031500161108100_","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41379-019-0208-x","article-title":"Metaplastic breast carcinoma: a clinical-pathologic study of 97 cases with subset analysis of response to neoadjuvant chemotherapy","volume":"32","author":"Han","year":"2019","journal-title":"Mod Pathol"},{"key":"2023031500161108100_","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41523-021-00302-z","article-title":"Poor response to neoadjuvant chemotherapy in metaplastic breast carcinoma","volume":"7","author":"Wong","year":"2021","journal-title":"NPJ Breast Cancer"},{"key":"2023031500161108100_","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10549-019-05264-2","article-title":"Metaplastic breast cancer has a poor response to neoadjuvant systemic therapy","volume":"176","author":"Al-Hilli","year":"2019","journal-title":"Breast Cancer Res Treat"},{"key":"2023031500161108100_","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/ajcp\/aqv097","article-title":"A clinicopathologic analysis of 45 patients with metaplastic breast carcinoma","volume":"145","author":"Cimino-Mathews","year":"2016","journal-title":"Am J Clin Pathol"},{"key":"2023031500161108100_","doi-asserted-by":"crossref","first-page":"107327482110048","DOI":"10.1177\/10732748211004889","article-title":"Metaplastic breast carcinoma: experience of a tertiary cancer center in the Middle East","volume":"28","author":"Erjan","year":"2021","journal-title":"Cancer Control"},{"year":"2022","author":"Gradishar","article-title":"NCCN Guidelines Version 4.2022 Breast Cancer [Internet]. 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