{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:19:49Z","timestamp":1773919189856,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Polyarteritis nodosa (PAN) is a necrotizing vasculitis commonly affecting small-sized vessels and medium-sized vessels. We present the case of surgical resection for ischemic colitis secondary to PAN. A 26-year-old woman presented with left lower quadrant pain, diarrhea and bloody stools. Colonoscopy showed diffuse circumferential ulceration and necrotic lining from the sigmoid colon to the splenic flexure. A subsequent computed tomography angiography (CTA) revealed left colonic wall thickening, hypoenhancement and multiple inferior mesenteric artery aneurysms, concerning for vasculitis. Ensuing laboratory workup all returned negative. Worsening pain, left-sided peritonitis, tachycardia and rising white blood cell necessitated a colectomy from the proximal descending to upper rectum with an end colostomy. Surgical pathology showed features consistent with PAN. The patient improved significantly after surgery and was discharged on a steroid taper and later started on mycophenolate mofetil. This case is a unique presentation of isolated large intestinal involvement and was treated with both medical and surgical interventions.<\/jats:p>","DOI":"10.1093\/jscr\/rjad195","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T21:33:38Z","timestamp":1681940018000},"source":"Crossref","is-referenced-by-count":2,"title":["Polyarteritis nodosa: a case report of isolated large bowel involvement and surgical intervention"],"prefix":"10.1093","volume":"2023","author":[{"given":"Georgina E","family":"Sellyn","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine , Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Kapil","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baldeep","family":"Pabla","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center , Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mujeeb Ur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Surgery, District Headquarter Hospital , Buner, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimal","family":"Khan","sequence":"additional","affiliation":[{"name":"Section of Surgical Sciences, Department of Colon and Rectal Surgery, Vanderbilt University Medical Center , Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"2023041921332610500_ref1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11926-021-00983-2","article-title":"Clinical approach to diagnosis and therapy of polyarteritis nodosa","volume":"23","author":"Ho\u010devar","year":"2021","journal-title":"Curr Rheumatol Rep"},{"key":"2023041921332610500_ref2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s12016-017-8612-9","article-title":"Cutaneous manifestations of medium- and large-vessel vasculitis","volume":"53","author":"Chasset","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"key":"2023041921332610500_ref3","volume-title":"Polyarteritis Nodosa","author":"Jacobs-Kosmin","year":"2021"},{"key":"2023041921332610500_ref4","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/ki.1985.104","article-title":"Renal vasculitis","volume":"27","author":"Balow","year":"1985","journal-title":"Kidney Int"},{"key":"2023041921332610500_ref5","first-page":"2022","volume-title":"Polyarteritis Nodosa","author":"Stanton"},{"key":"2023041921332610500_ref6","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cgh.2008.04.004","article-title":"Gastrointestinal involvement in polyarteritis nodosa","volume":"6","author":"Ebert","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2023041921332610500_ref7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.berh.2009.03.001","article-title":"The diagnosis of vasculitis","volume":"23","author":"Jayne","year":"2009","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2023041921332610500_ref8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/art.10922","article-title":"Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: a prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty-five patients","volume":"49","author":"Guillevin","year":"2003","journal-title":"Arthritis Rheum"},{"key":"2023041921332610500_ref9","first-page":"e21509","article-title":"Colonic perforation in polyarteritis nodosa with concurrent perforated sigmoid diverticulitis","volume":"14","author":"Leung","year":"2022","journal-title":"Cureus"},{"key":"2023041921332610500_ref10","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/art.27340","article-title":"French vasculitis study group. Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: a prospective randomized study of one hundred twenty-four patients","volume":"62","author":"Ribi","year":"2010","journal-title":"Arthritis Rheum"},{"key":"2023041921332610500_ref11","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0002-9343(01)01131-7","article-title":"Gastrointestinal involvement in polyarteritis nodosa (1986-2000): presentation and outcomes in 24 patients","volume":"112","author":"Levine","year":"2002","journal-title":"Am J Med"},{"key":"2023041921332610500_ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/741047","article-title":"Ischemic colitis revealing polyarteritis nodosa","volume":"2013","author":"Hamzaoui","year":"2013","journal-title":"Case Rep Med"},{"key":"2023041921332610500_ref13","doi-asserted-by":"crossref","first-page":"S861","DOI":"10.14309\/01.ajg.0000595732.01721.bf","article-title":"1551\u2003the vasculitic mimic: polyarteritis nodosa initially presenting with colonic involvement","volume":"114","author":"Lorio","year":"2019","journal-title":"Am J Gastroenterol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/4\/rjad195\/50032952\/rjad195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/4\/rjad195\/50032952\/rjad195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T21:33:47Z","timestamp":1681940027000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjad195\/7130981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,1]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjad195","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4]]},"published":{"date-parts":[[2023,4,1]]},"article-number":"rjad195"}}