{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:08Z","timestamp":1753877228906,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gastrointestinal (GI) intestinal stromal tumors account for 60% of mesenchymal GI tract tumors commonly located in the stomach and small intestine, predominantly solid tumors that rarely undergo cystic degeneration. A 65-year-old patient with increasing upper abdominal swelling and a computed tomography scan abdomen showed a large unilocular 17\u2009\u00d7\u200916\u2009\u00d7\u200915 cm lesion. A colossal cystic swelling in the lesser omentum, anterior to the stomach, was found upon exploration. Histopathological examination showed a spindle cell tumor turned out to be CD117 positive and S100 negative on immunostains. The tumor was moderate risk gastric gastrointestinal intestinal stromal tumor (GIST) based on the site; Stomach, Size &amp;gt;10\u00a0cm; Mitosis &amp;lt;5\/5\u00a0mm2 according to risk assessment of GIST, 2006. GISTs are predominantly solid tumors and rarely undergo cystic transformation. The primary differential diagnoses of spindle cell neoplasm are GISTs, Leiomyoma, Leiomyosarcoma and Schwannoma. These spindle cell neoplasms are differentiated by applying a panel of Immunohistochemical stains, CD117, SMA and S100.<\/jats:p>","DOI":"10.1093\/jscr\/rjad241","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T23:32:15Z","timestamp":1685057535000},"source":"Crossref","is-referenced-by-count":0,"title":["Rare serosal cystic gastric gastrointestinal stromal tumor with extensive intestinal metaplasia in an adherent gastric mucosa; a case report in a 65-year-old male"],"prefix":"10.1093","volume":"2023","author":[{"given":"Pir Muneeb","family":"Rehman","sequence":"first","affiliation":[{"name":"Department of Surgery , Azra Naheed Medical College, Lahore , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariha","family":"Sahrish","sequence":"additional","affiliation":[{"name":"Department of Histopathology , Azra Naheed Medical College, Lahore , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Histopathology , Azra Naheed Medical College, Lahore , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba","family":"Tariq","sequence":"additional","affiliation":[{"name":"Department of Radiology , Azra Naheed Medical College, Lahore , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Shoaib","sequence":"additional","affiliation":[{"name":"Department of Surgery , Azra Naheed Medical College, Lahore , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehrish","family":"Rubab","sequence":"additional","affiliation":[{"name":"Department of Radiology , University Hospital Crosshouse, Glasgow, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhamad","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of Physiology , Continental Medical College, Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehwish","family":"Niazi","sequence":"additional","affiliation":[{"name":"Department of Histopathology , Azra Naheed Medical College, Lahore , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saima","family":"Irum","sequence":"additional","affiliation":[{"name":"Department of Hematology , Azra Naheed Medical College, Lahore , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Aqeel","sequence":"additional","affiliation":[{"name":"Department of Surgery , Azra Naheed Medical College, Lahore , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"2023052523320247800_ref1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.31080\/ASGIS.2021.04.0250","article-title":"Giant GIST of the stomach masquerading gigantic cyst located in the upper part of the peritoneal cavity","volume":"4","author":"Bayramov","year":"2021","journal-title":"Acta Scientific Gastrointestinal Disorders"},{"key":"2023052523320247800_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12957-017-1285-2","article-title":"Giant gastrointestinal stromal tumor with predominantly cystic changes: a case report and literature review","volume":"15","author":"Wang","year":"2017","journal-title":"World J Surg Oncol"},{"key":"2023052523320247800_ref3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ijc.33536","article-title":"Neoadjuvant therapy for gastrointestinal stromal tumors: a propensity score-weighted analysis","volume":"149","author":"Marqueen","year":"2021","journal-title":"Int J Cancer"},{"key":"2023052523320247800_ref4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijscr.2015.04.037","article-title":"A rare case of giant gastrointestinal stromal tumor of the stomach involving the serosal surface","volume":"12","author":"Koyuncuer","year":"2015","journal-title":"Int J Surg Case Rep"},{"key":"2023052523320247800_ref5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ccr3.92","article-title":"Gastrointestinal stromal tumor (GIST) mistaken for pancreatic pseudocyst\u2013case report and literature review","volume":"2","author":"Hansen","year":"2014","journal-title":"Clin Case Rep"},{"key":"2023052523320247800_ref6","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.3892\/ol.2014.1954","article-title":"Exophytic gastrointestinal stromal tumor with cystic changes: a case report","volume":"7","author":"Zhu","year":"2014","journal-title":"Oncol Lett"},{"key":"2023052523320247800_ref7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12328-015-0577-8","article-title":"A case of a stomach gastrointestinal stromal tumor with extremely predominant cystic formation","volume":"8","author":"Okano","year":"2015","journal-title":"Clin J Gastroenterol"},{"key":"2023052523320247800_ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/6170861","article-title":"Gigantic GIST: a case of the largest gastrointestinal stromal tumor found to date","volume":"2018","author":"Mohamed","year":"2018","journal-title":"Case Rep Surg"},{"key":"2023052523320247800_ref9","article-title":"Histomorphological Spectrum and Immunohistochemical features of gastrointestinal stromal tumour: a series of eight cases","volume":"16","year":"2022","journal-title":"J Clin Diagnostic Res"},{"key":"2023052523320247800_ref10","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.7314\/APJCP.2015.16.12.4873","article-title":"Gastrointestinal stromal tumors: a clinicopathological and risk stratification study of 255 cases from Pakistan and review of the literature","volume":"16","author":"Din","year":"2015","journal-title":"Asian Pac J Cancer Prev"},{"key":"2023052523320247800_ref11","first-page":"187","article-title":"Synchronous primary adenocarcinoma and gastrointestinal stromal tumor in the stomach: a report of two cases","volume":"15","author":"Bircan","year":"2004","journal-title":"Turk J Gastroenterol"},{"key":"2023052523320247800_ref12","article-title":"Gastrointestinal stromal tumor (GIST): case study. International research","volume":"5","author":"","year":"2022","journal-title":"J Gastroenterol Hepatol"},{"key":"2023052523320247800_ref13","first-page":"150","article-title":"Gastrointestinal stromal tumor (GIST) with glandular component. A report of an unusual tumor resembling adenosarcoma","volume":"41","author":"Zamecnik","year":"2005","journal-title":"Cesk Patol"},{"key":"2023052523320247800_ref14","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1177\/000313481608201126","article-title":"A review of sleeve gastrectomy specimen histopathology","volume":"82","author":"Kinsinger","year":"2016","journal-title":"Am Surg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/5\/rjad241\/50452814\/rjad241.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/5\/rjad241\/50452814\/rjad241.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T23:32:23Z","timestamp":1685057543000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjad241\/7179768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjad241","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,5,1]]},"article-number":"rjad241"}}