{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:28:44Z","timestamp":1769941724004,"version":"3.49.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Secondary chronic osteomyelitis (SCO) is caused by bacterial infection leading to progressive jawbone destruction. Antibiotics are used as first-line treatment; surgical therapy is usually extensive and may not provide a cure. Bisphosphonates have been reported to be successful in patients with primary nonbacterial osteomyelitis, and literature indicates promising results in SCO. A 38-year-old patient presented with a progressive mandible-destruction 17\u00a0years after wisdom tooth extraction. Several treatment attempts have been unsuccessful. Seeking a second opinion, the patient was then interdisciplinary treated with 90\u00a0mg of intravenous pamidronate every four weeks, three times. The patient did not experience side effects presenting a considerable improvement in mouth opening and reporting a dissolvent of signs of pain or infection. The MRI showed edema reduction and decreased contrast uptake. Therefore, bisphosphonate treatment of secondary chronic osteomyelitis of the jaw is a safe and effective option in selected cases after unsuccessful first- and second-line therapy.<\/jats:p>","DOI":"10.1093\/jscr\/rjad270","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T23:42:21Z","timestamp":1685058141000},"source":"Crossref","is-referenced-by-count":6,"title":["Bisphosphonate-treatment of secondary chronic osteomyelitis of the jaw \u2013 a case report"],"prefix":"10.1093","volume":"2023","author":[{"given":"Diana","family":"Heimes","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Medical Center Mainz , 55131 Mainz , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peer W","family":"K\u00e4mmerer","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Medical Center Mainz , 55131 Mainz , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"2023052523421350800_ref1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/978-3-540-28766-7_2","volume-title":"Osteomyelitis of the Jaws","author":"Baltensperger","year":"2009"},{"key":"2023052523421350800_ref2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/ors.12578","article-title":"Secondary chronic osteomyelitis of the mandible: a resistant disease successfully treated with bisphosphonate therapy","volume":"14","author":"Cheng","year":"2020","journal-title":"Oral Surgery"},{"key":"2023052523421350800_ref3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bjoms.2020.01.012","article-title":"Outcome of different treatments for chronic diffuse sclerosing osteomyelitis of the mandible: a systematic review of published papers","volume":"58","author":"Meent","year":"2020","journal-title":"Br J Oral Maxillofac Surg"},{"key":"2023052523421350800_ref4","first-page":"142","article-title":"Is zoledronate a safe and effective treatment option in chronic nonbacterial osteomyelitis?","volume":"98","author":"Gonzalez Vazquez","year":"2023","journal-title":"An Pediatr (Engl Ed)"},{"key":"2023052523421350800_ref5","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.oooo.2020.06.023","article-title":"Application of pamidronate disodium for the treatment of diffuse sclerosing osteomyelitis of the mandible: a clinical study","volume":"130","author":"Li","year":"2020","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"2023052523421350800_ref6","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.ijom.2020.06.017","article-title":"Oral administration of alendronate and vitamin D3 for the treatment of chronic non-bacterial osteomyelitis of the jaw","volume":"49","author":"Yang","year":"2020","journal-title":"Int J Oral Maxillofac Surg"},{"key":"2023052523421350800_ref7","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.jcms.2015.08.028","article-title":"Ibandronate treatment of diffuse sclerosing osteomyelitis of the mandible: pain relief and insight into pathogenesis","volume":"43","author":"Otto","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"2023052523421350800_ref8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1752-1947-8-44","article-title":"Non-infectious osteomyelitis of the mandible in a young woman: a case report","volume":"8","author":"Rasmussen","year":"2014","journal-title":"J Med Case Reports"},{"key":"2023052523421350800_ref9","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s00223-018-0495-0","article-title":"Chronic non-bacterial osteomyelitis: a review","volume":"104","author":"Buch","year":"2019","journal-title":"Calcif Tissue Int"},{"key":"2023052523421350800_ref10","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.joms.2014.10.017","article-title":"Chronic osteomyelitis of the mandible: diagnosis and management--an institution's experience over 7 years","volume":"73","author":"Baur","year":"2015","journal-title":"J Oral Maxillofac Surg"},{"key":"2023052523421350800_ref11","first-page":"248","article-title":"Garr\u00e9's osteomyelitis of the mandible; 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