{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:53:47Z","timestamp":1775786027217,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Extramammary Paget disease (EMPD) is an uncommon slow-growing skin adenocarcinoma originating in the anogenital region and axilla outside the mammary glands, often in regions with apocrine glands. The most common location is the vulva, followed by perineal, perianal, scrotal and penile skin. Here, we report a case of a 63-year-old male with EMPD in the perianal region. He reported 4\u00a0years of pain associated with an increasing region of skin irritation and bleeding on defecation that did not improve with topical agents. A biopsy sample revealed poorly differentiated carcinoma consistent with adenocarcinoma and associated with Paget disease. Workup was done. The patient tolerated local excision of the region well with no complications. A rare disease, EMPT, is challenging to diagnose and manage. Histopathological findings can, however, differentiate it from a wide array of similar skin conditions. Thorough investigations should be undertaken before initiating treatment to ensure the best outcomes.<\/jats:p>","DOI":"10.1093\/jscr\/rjad291","type":"journal-article","created":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T13:14:51Z","timestamp":1687094091000},"source":"Crossref","is-referenced-by-count":2,"title":["Perianal extramammary Paget\u2019s disease with adenocarcinoma of perianal skin area, a case report"],"prefix":"10.1093","volume":"2023","author":[{"given":"Alhasan H","family":"Alhebshi","sequence":"first","affiliation":[{"name":"International Medical Center in Jeddah , Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Aldekhail","sequence":"additional","affiliation":[{"name":"Al-Qassim University Medical School , Qassim , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Abduljabbar","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital and Research Center in Riyadh , Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"2023061813144318600_ref1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/j.1600-0560.2009.01174.x","article-title":"Pigmented extramammary Paget's disease of the axilla mimicking melanoma: case report and review of the literature","volume":"36","author":"Hilliard","year":"2009","journal-title":"J Cutan Pathol"},{"key":"2023061813144318600_ref2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fonc.2018.00038","article-title":"Metastatic extramammary Paget\u2019s disease: pathogenesis and novel therapeutic approach","volume":"8","author":"Fukuda","year":"2018","journal-title":"Front Oncol"},{"key":"2023061813144318600_ref3","doi-asserted-by":"crossref","first-page":"106796","DOI":"10.1016\/j.ijscr.2022.106796","article-title":"Stein J stage 3 perianal extra mammary Paget's disease: a case report of a non-operative approach","volume":"91","author":"Apikotoa","year":"2022","journal-title":"Int J Surg Case Rep"},{"key":"2023061813144318600_ref4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.14740\/gr727e","article-title":"Extramammary Paget's disease of anal canal associated with rectal adenoma without invasive carcinoma","volume":"9","author":"Chumbalkar","year":"2016","journal-title":"Gastroenterology Res"},{"key":"2023061813144318600_ref5","doi-asserted-by":"crossref","first-page":"713786","DOI":"10.3389\/fonc.2021.713786","article-title":"Extramammary Paget's disease in the genital area of a male: a case report and review of the literature","volume":"11","author":"Zhao","year":"2021","journal-title":"Front Oncol"},{"key":"2023061813144318600_ref6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000514253","article-title":"A case report of familial extramammary Paget's disease in female siblings","volume":"13","author":"Rutnumnoi","year":"2021","journal-title":"Case Rep Dermatol"},{"key":"2023061813144318600_ref7","doi-asserted-by":"crossref","first-page":"rjab262","DOI":"10.1093\/jscr\/rjab262","article-title":"Extramammary Paget disease: five perianal case report and treatment options","volume":"2021","author":"Deng","year":"2021","journal-title":"J Surg Case Rep"},{"key":"2023061813144318600_ref8","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.mayocp.2018.02.024","article-title":"Evidence-based screening recommendations for occult cancers in the setting of newly diagnosed extramammary Paget disease","volume":"93","author":"Schmitt","year":"2018","journal-title":"Mayo Clin Proc"},{"key":"2023061813144318600_ref9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1186\/1471-2407-10-405","article-title":"Extramammary Paget's disease with the appearance of a nodule: a case report","volume":"10","author":"Wang","year":"2010","journal-title":"BMC Cancer"},{"key":"2023061813144318600_ref10","first-page":"72","article-title":"An advanced case of extramammary Paget disease: safe and effective treatment in an inoperable elderly patient using extensive en face electron irradiation","volume-title":"JAAD Case Rep","author":"Valle","year":"2019"},{"key":"2023061813144318600_ref11","first-page":"250","article-title":"Radiotherapy for invasive extramammary Paget's disease: a case report","volume-title":"Dermatologica Sinica","author":"Lin","year":"2020"},{"key":"2023061813144318600_ref12","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s10350-004-6618-x","article-title":"Long-term outcome of perianal Paget's disease","volume":"46","author":"McCarter","year":"2003","journal-title":"Dis Colon Rectum"},{"key":"2023061813144318600_ref13","first-page":"313","article-title":"Extramammary Paget's disease: treatment, prognostic factors and outcome in 76 patients","volume":"158","author":"Hatta","year":"2008","journal-title":"Br J Dermatol"},{"key":"2023061813144318600_ref14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4137\/CMO.S13107","article-title":"Advanced extramammary Paget\u2019s disease of the groin, penis, and scrotum","volume":"8","author":"Isrow","year":"2014","journal-title":"Clin Med Insights Oncol"},{"key":"2023061813144318600_ref15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s13193-016-0551-z","article-title":"Extra mammary Paget's disease of vulva: a case report","volume":"7","author":"Tomar","year":"2016","journal-title":"Indian J Surg Oncol"},{"key":"2023061813144318600_ref16","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.4081\/dr.2020.8841","article-title":"Metastatic extramammary Paget disease: a remarkable clinical case and a brief review of a rare disease","volume":"12","author":"Fernandes","year":"2020","journal-title":"Dermatol Reports"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/6\/rjad291\/50627542\/rjad291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/6\/rjad291\/50627542\/rjad291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T13:14:59Z","timestamp":1687094099000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjad291\/7199514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjad291","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,6,1]]},"article-number":"rjad291"}}