{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:23:16Z","timestamp":1773829396512,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Primary leptomeningeal melanoma is an extremely rare type of intracranial melanoma. It cannot be reliably distinguished from metastatic melanoma on neuroimaging and histopathological characteristics alone; its diagnosis is established only after exclusion of secondary metastatic disease from a cutaneous, mucosal or retinal primary. Prognosis is poor, partly due to its high rate of misdiagnosis. Herein, we report a case of a primary meningeal melanoma of the skull base with melanomatosis, in a 31-year-old man, mimicking meningioma. Our aim is to highlight the diagnostic pitfalls and to discuss the histopathological differential diagnoses, especially with other pigmented lesions of central nervous system.<\/jats:p>","DOI":"10.1093\/jscr\/rjad323","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T23:31:36Z","timestamp":1686612696000},"source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic challenge: primary leptomeningeal melanoma with melanomatosis, illustrative case report"],"prefix":"10.1093","volume":"2023","author":[{"given":"Hafsa","family":"El Ouazzani","sequence":"first","affiliation":[{"name":"Ibn Sina University Hospital Center in Rabat Department of Pathology HSR, , Morocco"},{"name":"Mohammed V University in Rabat , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Yassaad","family":"Oudghiri","sequence":"additional","affiliation":[{"name":"Mohammed V University in Rabat , Morocco"},{"name":"Ibn Sina University Hospital Center in Rabat Department of Neurosurgery HSR, , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Abbas","sequence":"additional","affiliation":[{"name":"Mohammed V University in Rabat , Morocco"},{"name":"Ibn Sina University Hospital Center in Rabat Department of Neurosurgery HSR, , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Regragui","sequence":"additional","affiliation":[{"name":"Mohammed V University in Rabat , Morocco"},{"name":"Ibn Sina University Hospital Center in Rabat Department of Neurosurgery HSR, , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdessamad","family":"Elouahabi","sequence":"additional","affiliation":[{"name":"Mohammed V University in Rabat , Morocco"},{"name":"Ibn Sina University Hospital Center in Rabat Department of Neurosurgery HSR, , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fouad","family":"Zouaidia","sequence":"additional","affiliation":[{"name":"Mohammed V University in Rabat , Morocco"},{"name":"Ibn Sina University Hospital Center in Rabat Department of Pathology Ibn Sina, , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Cherradi","sequence":"additional","affiliation":[{"name":"Ibn Sina University Hospital Center in Rabat Department of Pathology HSR, , Morocco"},{"name":"Mohammed V University in Rabat , Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"2023061223311927300_ref1","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.3892\/ol.2015.3537","article-title":"Intracranial malignant melanoma: a report of 7 cases","volume":"10","author":"Yunfeng","year":"2015","journal-title":"Oncol Lett"},{"key":"2023061223311927300_ref2","doi-asserted-by":"crossref","first-page":"03","DOI":"10.3109\/02841868909111189","article-title":"Primary meningeal melanoma","volume":"28","author":"Helseth","year":"1989","journal-title":"Acta Oncol"},{"key":"2023061223311927300_ref3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0090-3019(01)00348-2","article-title":"Primitive cerebral melanoma: case report and review of the literature","volume":"55","author":"Grecocrasto","year":"2001","journal-title":"Surg Neurol"},{"key":"2023061223311927300_ref4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12883-019-1460-x","article-title":"Primary diffuse meningeal melanomatosis \u2013 a rare form of meningeal melanoma: case report","volume":"19","author":"Garbacz","year":"2019","journal-title":"BMC Neurol"},{"key":"2023061223311927300_ref5","first-page":"340","volume-title":"Melanocytic tumours. In WHO Classification of Tumours Editirial Board: Central Nervous System Tumors","author":"Singh","year":"2021","edition":"5th"},{"key":"2023061223311927300_ref6","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1440-1789.2010.01160.x","article-title":"Malignant transformation of intracranial meningeal melanocytoma. Case report and review of the literature","volume":"31","author":"Fulin","year":"2011","journal-title":"Neuropathology"},{"key":"2023061223311927300_ref7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3171\/spi.2007.6.5.451","article-title":"Malignant transformation of spinal meningeal melanocytoma. Case report and review of the literature","volume":"6","author":"Wang","year":"2007","journal-title":"J Neurosurg Spine"},{"key":"2023061223311927300_ref8","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jocn.2009.12.020","article-title":"The diagnostic dilemma of primary central nervous system melanoma","volume":"17","author":"Tabassum","year":"2010","journal-title":"J Clin Neurosci"},{"key":"2023061223311927300_ref9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00008390-200510000-00017","article-title":"Central nervous system as exclusive site of disease in patients with melanoma: treatment and clinical outcome of two cases","volume":"15","author":"Ferraresi","year":"2005","journal-title":"Melanoma Res"},{"key":"2023061223311927300_ref10","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.5858\/arpa.2017-0162-RA","article-title":"Pathology of melanotic schwannoma","volume":"142","author":"Borislav","year":"2018","journal-title":"Arch Pathol Lab Med"},{"key":"2023061223311927300_ref11","article-title":"Primary meningeal melanoma masquerading as neurofibromatosis type 2: illustrative case","volume":"2","author":"Melanie","journal-title":"J Neurosurg Case Lessons"},{"key":"2023061223311927300_ref12","first-page":"1","article-title":"Two cases of primary leptomeningeal melanomatosis mimicking subacute meningitis","volume":"0","author":"Sabina","year":"2017","journal-title":"Neuroradiol J"},{"key":"2023061223311927300_ref13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00001622-200403000-00014","article-title":"Management of brain metastases in patients with melanoma","volume":"16","author":"Tarhini","year":"2004","journal-title":"Curr Opin Oncol"},{"key":"2023061223311927300_ref14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12967-020-02212-3","article-title":"Bevacizumab treatment of meningeal melanoma metastases","volume":"18","author":"Simonsen","year":"2020","journal-title":"J Transl Med"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/6\/rjad323\/50572979\/rjad323.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/6\/rjad323\/50572979\/rjad323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T23:31:50Z","timestamp":1686612710000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjad323\/7194182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjad323","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,6,1]]},"article-number":"rjad323"}}