{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:56:14Z","timestamp":1753876574536,"version":"3.41.2"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Leiomyosarcomas of the uterine cervix are rare, mostly occurring in perimenopausal women. Diagnosis is based on pathology and immunohistochemistry. Surgery with a total abdominal hysterectomy and bilateral salpingo-oophorectomy remains the standard. A female patient in her 60s presented with heavy postmenopausal bleeding. Vaginal ultrasound scan and magnetic resonance imaging showed a large strongly vascularized cervical mass with features suspicious of sarcomatous degeneration. Positron Emission Tomography-Computed Tomography (PET-CT) did not reveal any evidence of metastases nor lymphadenopathy, but presence of right hydronephrosis. An abdominal hysterectomy with bilateral salpingo-oophorectomy, and end-to-end anastomosis of the right ureter, was performed. Pathology showed an International Federation of Gynecology and Obstetrics (FIGO)-stage 1B leiomyosarcoma of the uterine cervix. No adjuvant treatment was given. Adjuvant radiotherapy reduces the risk of recurrence but no survival impact. The benefit of adjuvant chemotherapy is questionable given the lack of randomized trials. Multidisciplinary research concerning molecular alterations of the disease is required to determine optimal management strategies with potential novel molecular therapies.<\/jats:p>","DOI":"10.1093\/jscr\/rjad439","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T09:01:12Z","timestamp":1691139672000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary leiomyosarcoma of the uterine cervix: an unusual case and critical appraisal"],"prefix":"10.1093","volume":"2023","author":[{"given":"Ines","family":"Lebbe","sequence":"first","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology, AZ Sint-Jan Hospital Bruges , Bruges , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eveline","family":"De Cuypere","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, AZ Sint-Jan Hospital Bruges , Bruges , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele","family":"Claes","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, AZ Sint-Jan Hospital Bruges , Bruges , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Loccufier","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology, AZ Sint-Jan Hospital Bruges , Bruges , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Ghysel","sequence":"additional","affiliation":[{"name":"Department of Urology, AZ Sint-Jan Hospital Bruges , Bruges , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9784-7974","authenticated-orcid":false,"given":"Philippe","family":"Van Trappen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Gynecological Oncology, AZ Sint-Jan Hospital Bruges , Bruges , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"2023080409010587500_ref1","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.18632\/oncotarget.26803","article-title":"Role of surgery in gynaecological sarcomas","volume":"10","author":"Ghirardi","year":"2019","journal-title":"Oncotarget"},{"key":"2023080409010587500_ref2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ygyno.2003.08.037","article-title":"Leiomyosarcoma of the cervix","volume":"91","author":"Irvin","year":"2003","journal-title":"Gynecol Oncol"},{"key":"2023080409010587500_ref3","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2020.31.e25","article-title":"Primary sarcoma of the cervix: an analysis of patient and tumor characteristics, treatment patterns, and outcomes","volume":"31","author":"Albert","year":"2020","journal-title":"J Gynecol Oncol"},{"key":"2023080409010587500_ref4","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.diii.2013.06.004","article-title":"MR perfusion for pelvic female imaging","volume":"94","author":"Thomassin-Naggara","year":"2013","journal-title":"Diagn Interv Imaging"},{"key":"2023080409010587500_ref5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/jcu.20386","article-title":"Can gray-scale and color Doppler sonography differentiate between uterine leiomyosarcoma and leiomyoma?","volume":"35","author":"Exacoustos","year":"2007","journal-title":"J Clin Ultrasound"},{"key":"2023080409010587500_ref6","doi-asserted-by":"crossref","first-page":"bcr2013008616","DOI":"10.1136\/bcr-2013-008616","article-title":"Case report: the uncovered story of leiomyosarcoma of the cervix: a rare case report and review of literature","volume":"2013","author":"Dhull","year":"2013","journal-title":"BMJ Case Reports"},{"key":"2023080409010587500_ref7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0090-8258(03)00137-9","article-title":"Retrospective review of 208 patients with leiomyosarcoma of the uterus: prognostic indicators, surgical management, and adjuvant therapy","volume":"89","author":"Giuntoli","year":"2003","journal-title":"Gynecol Oncol"},{"key":"2023080409010587500_ref8","first-page":"185","article-title":"Prognostic factors in uterine leiomyosarcoma: a clinical and histopathological study of 143 cases. 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