{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:36:06Z","timestamp":1757777766058,"version":"3.41.2"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T00:00:00Z","timestamp":1694908800000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mixed malignant M\u00fcllerian tumors (MMMTs) are rare and aggressive neoplasms made up of both carcinomatous and sarcomatous components that primarily appear in the female reproductive tract. The cellular origin of this malignancy has eluded advancements in molecular and immunohistochemical techniques contributing to the limited diagnostic and therapeutic strategies. This case report presents a 41-year-old female with a history of abnormal uterine bleeding and dysmenorrhea who was later diagnosed with an MMMT. This case highlights the importance of considering MMMTs in patients with a long-standing history of abnormal uterine bleeding because the prompt recognition and diagnosis of this condition may lead to an improved overall survival for these patients.<\/jats:p>","DOI":"10.1093\/jscr\/rjad523","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T22:15:36Z","timestamp":1694988936000},"source":"Crossref","is-referenced-by-count":1,"title":["Challenges in diagnosis and treatment: a case report on a mixed malignant M\u00fcllerian tumor"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3135-732X","authenticated-orcid":false,"given":"Daniela","family":"Saenz","sequence":"first","affiliation":[{"name":"Department of Medical Research, Universidad Francisco Marroqu\u00edn , Guatemala City 01010 , Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4617-8046","authenticated-orcid":false,"given":"Jorge D","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Universidad Francisco Marroqu\u00edn , Guatemala City 01010 , Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-1904","authenticated-orcid":false,"given":"Juan P","family":"C\u00f3bar","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Universidad Francisco Marroqu\u00edn , Guatemala City 01010 , Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,16]]},"reference":[{"key":"2023091722152565400_ref1","first-page":"1","article-title":"Clinical features, diagnosis, staging, and treatment of uterine carcinosarcoma","author":"Penson","year":"2016"},{"key":"2023091722152565400_ref2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.critrevonc.2014.10.013","article-title":"Rare uterine cancer: carcinosarcomas: review from histology to treatment","volume":"94","author":"Artioli","year":"2015","journal-title":"Crit Rev Oncol Hematol"},{"key":"2023091722152565400_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/569609","article-title":"Malignant mixed mullerian tumor: an immunohistochemical study","volume":"2012","author":"Bing","year":"2012","journal-title":"Pathol Res Int"},{"key":"2023091722152565400_ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/470795","article-title":"Uterine Carcinosarcomas (malignant mixed M\u00fcllerian tumours): a review with special emphasis on the controversies in management","volume":"2011","author":"Kanthan","year":"2011","journal-title":"Obstet Gynecol Int"},{"volume-title":"Uterine Sarcoma: Classification, Epidemiology, Clinical Manifestations, and Diagnosis - UpToDate","year":"2019","author":"Memarzadeh","key":"2023091722152565400_ref5"},{"key":"2023091722152565400_ref6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/jnci\/djh007","article-title":"Risk of malignant mixed Mullerian tumors after tamoxifen therapy for breast cancer","volume":"96","author":"Curtis","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"2023091722152565400_ref7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4103\/0973-1482.138197","article-title":"Review literature on uterine carcinosarcoma","volume":"10","author":"Singh","year":"2014","journal-title":"J Cancer Res Ther"},{"key":"2023091722152565400_ref8","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.bpobgyn.2011.05.010","article-title":"Pathology of mixed M\u00fcllerian tumours","volume":"25","author":"D\u2019Angelo","year":"2011","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2023091722152565400_ref9","first-page":"16","article-title":"Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells","volume-title":"Medicines (Basel)","author":"Testa","year":"2018"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/9\/rjad523\/51626320\/rjad523.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/9\/rjad523\/51626320\/rjad523.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T22:15:42Z","timestamp":1694988942000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjad523\/7275625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjad523","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2023,9]]},"published":{"date-parts":[[2023,9]]},"article-number":"rjad523"}}