{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:34Z","timestamp":1753877194938,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T00:00:00Z","timestamp":1697328000000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Perivascular epithelioid cell neoplasm (PEComa) is a rare type of tumor, and hepatic PEComa is even rarer. Its preoperative diagnosis is difficult, given the absence of specific clinical manifestations, often constituting an accidental finding, and the lack of a gold standard for identification using imaging studies. Instead, the diagnosis of hepatic PEComa is based on morphological and immunohistochemical features. We describe a case of an asymptomatic hepatic PEComa, angiomyolipoma type, which appeared in a middle-aged woman with chronic liver disease, during her follow-up and screening. Given the patient's context, human immunodeficiency virus-positive with chronic hepatitis C, and the similarities between the two tumors, the hepatic lesion was interpreted as hepatocellular carcinoma. The patient underwent surgical excision of the tumor, and the positive immunohistochemical staining for human melanoma black 45 and Melan A made the definitive diagnosis. In the absence of aggressiveness tumor markers, surveillance was decided. We also provide a literature review of these tumors.<\/jats:p>","DOI":"10.1093\/jscr\/rjad556","type":"journal-article","created":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T17:47:40Z","timestamp":1697392060000},"source":"Crossref","is-referenced-by-count":2,"title":["Hepatic angiomyolipoma, misdiagnosed as hepatocellular carcinoma"],"prefix":"10.1093","volume":"2023","author":[{"given":"B\u00e1rbara M","family":"Marinho","sequence":"first","affiliation":[{"name":"General Surgery Service, Department of Surgery, Centro Hospitalar Universit\u00e1rio do Porto , EPE, 4099-001 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio G","family":"Canha","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Pancreatic Unit, Department of Surgery, Centro Hospitalar Universit\u00e1rio do Porto , EPE, 4099-001 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donz\u00edlia S","family":"Silva","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Pancreatic Unit, Department of Surgery, Centro Hospitalar Universit\u00e1rio do Porto , EPE, 4099-001 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana P","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Service, Department of Pathology, Centro Hospitalar Universit\u00e1rio do Porto , EPE, 4099-001 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,14]]},"reference":[{"key":"2023101517473211600_ref1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/jso.21814","article-title":"Diagnosis and treatment of hepatic angiomyolipoma","volume":"103","author":"Ding","year":"2011","journal-title":"J Surg Oncol"},{"key":"2023101517473211600_ref2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.hpb.2019.09.004","article-title":"Hepatic angiomyolipoma: an international multicenter analysis on diagnosis, management and outcome","volume":"22","author":"Klompenhouwer","year":"2020","journal-title":"Hpb [Internet]"},{"key":"2023101517473211600_ref3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000509192","article-title":"A rare case of PEComa of the liver","volume":"28","author":"Attard","year":"2021","journal-title":"GE Port J Gastroenterol"},{"key":"2023101517473211600_ref4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1155\/2013\/904126","article-title":"PEComa: a perivascular epithelioid cell tumor in the liver - a case report and review of the literature","volume":"2013","author":"Khaja","year":"2013","journal-title":"Case Rep Med"},{"key":"2023101517473211600_ref5","doi-asserted-by":"crossref","first-page":"bcr2014204122","DOI":"10.1136\/bcr-2014-204122","article-title":"Hepatic PEComa: a potential pitfall in the evaluation of hepatic neoplasms","volume":"2014","author":"Khan","year":"2014","journal-title":"BMJ Case Rep"},{"key":"2023101517473211600_ref6","first-page":"1169","article-title":"Angiomyolipoma of the liver: a rare benign tumor treated with a laparoscopic approach for the first time","volume":"31","author":"Damaskos","year":"2017","journal-title":"In Vivo (Brooklyn)"},{"key":"2023101517473211600_ref7","doi-asserted-by":"crossref","first-page":"e3890","DOI":"10.1097\/MD.0000000000003890","article-title":"A systematic review: perivascular epithelioid cell tumor of gastrointestinal tract","volume":"95","author":"Chen","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2023101517473211600_ref8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3350\/cmh.2016.0034","article-title":"Hepatic perivascular epithelioid cell tumor (PEComa): a case report with a review of literatures","volume":"23","author":"Son","year":"2017","journal-title":"Clin Mol Hepatol"},{"key":"2023101517473211600_ref9","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s13193-012-0169-8","article-title":"Acute abdomen as an unusual presentation of broad ligament angiomyolipoma. A case report and review of literature","volume":"3","author":"Shakuntala","year":"2012","journal-title":"Indian J Surg Oncol"},{"key":"2023101517473211600_ref10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5603\/OCP.2020.0003","article-title":"Diagnosis and treatment of malignant PEComa tumours","volume":"16","author":"Sobiborowicz","year":"2020","journal-title":"Oncol Clin Pract"},{"key":"2023101517473211600_ref11","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1590\/abd1806-4841.20187595","article-title":"Malignant subcutaneous PEComa on the cheek","volume":"93","author":"Girardi","year":"2018","journal-title":"An Bras Dermatol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/10\/rjad556\/52137713\/rjad556.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/10\/rjad556\/52137713\/rjad556.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T17:47:44Z","timestamp":1697392064000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjad556\/7317496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjad556","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2023,10]]},"published":{"date-parts":[[2023,10]]},"article-number":"rjad556"}}