{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:13:11Z","timestamp":1782846791767,"version":"3.54.5"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High-grade appendiceal mucinous neoplasms (HAMN) are rare mucinous appendiceal tumors that are mostly incidentally discovered and histologically show marked cytoplasmic atypia. We report a 62-year-old female patient who was diagnosed with acute right flank pain mimicking renal colic. Abdominal and pelvis CT scans showed no calculi or hydronephrosis. Incidentally, a markedly distended retrocecal appendix was identified and an appendectomy was performed. Histopathology revealed an HAMN of size 5.8\u00a0cm. HAMN are one of the rare and somewhat recently described epithelial appendiceal tumors. The latest 2019 classification is based on histologic appearance and on the consensus for classification and pathologic reporting of Pseudomyxoma peritonei and associated appendiceal neoplasia (Peritoneal Surface Pathology Group International, modified Delphi process). Histologically, appendiceal mucinous lesions are classified as nonneoplastic\/mucocele and neoplastic lesions with separate subcategorization. Despite its rarity, it is crucial for clinicians to be aware of HAMN to distinguish it from other clinical differentials.<\/jats:p>","DOI":"10.1093\/jscr\/rjad567","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T03:11:03Z","timestamp":1697598663000},"source":"Crossref","is-referenced-by-count":3,"title":["High-grade appendiceal mucinous neoplasm presenting as renal colic; a case report and review of literature"],"prefix":"10.1093","volume":"2023","author":[{"given":"Baraa","family":"Amir","sequence":"first","affiliation":[{"name":"Imam Abdulrahman Bin Faisal University , Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaar","family":"Amir","sequence":"additional","affiliation":[{"name":"Imam Abdulrahman Bin Faisal University , Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwa","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Pathology Services, John Hopkins Aramco Healthcare , Dhahran 34455, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"2023101720464557000_ref1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.55418\/9781933477398-05","volume-title":"Tumors of the Intestines","author":"Montgomery","year":"2017"},{"key":"2023101720464557000_ref2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/PAS.0000000000000535","article-title":"A consensus for classification and pathologic reporting of Pseudomyxoma Peritonei and associated appendiceal neoplasia","volume":"40","author":"Carr","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"2023101720464557000_ref3","article-title":"Appendiceal mucinous lesions","author":"Overman"},{"key":"2023101720464557000_ref4","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1097\/00000478-200308000-00006","article-title":"Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases","volume":"27","author":"Misdraji","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"2023101720464557000_ref5","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1097\/PAS.0b013e3181af6067","article-title":"Clinicopathologic study of 116 cases with analysis of factors predicting recurrence","volume":"33","author":"Pai","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"2023101720464557000_ref6","first-page":"144","volume-title":"Who Classification of Tumours: Digestive System","author":"Misdraji","year":"2019","edition":"5th"},{"key":"2023101720464557000_ref7","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0002-9440(10)65442-9","article-title":"Molecular genetic evidence supporting the clonality and appendiceal origin of Pseudomyxoma Peritonei in women","volume":"154","author":"Szych","year":"1999","journal-title":"Am J Pathol"},{"key":"2023101720464557000_ref8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/bjc.2013.47","article-title":"Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms","volume":"108","author":"Nishikawa","year":"2013","journal-title":"Br J Cancer"},{"key":"2023101720464557000_ref9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/his.13986","article-title":"Mutation profile of high-grade appendiceal mucinous neoplasm","volume":"76","author":"Liao","year":"2019","journal-title":"Histopathology"},{"key":"2023101720464557000_ref10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3322\/caac.21388","article-title":"The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/10\/rjad567\/52190739\/rjad567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/10\/rjad567\/52190739\/rjad567.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T03:11:09Z","timestamp":1697598669000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjad567\/7319952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjad567","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10]]},"published":{"date-parts":[[2023,10]]},"article-number":"rjad567"}}