{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:57:58Z","timestamp":1764053878182,"version":"3.41.2"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Portal hypertension, often stemming from liver cirrhosis or vascular anomalies, can result in cavernous transformation of the portal vein, a rare condition associated with biliary obstruction, variceal hemorrhage, and splenomegaly. This case report details a unique occurrence of portal hypertension, splenomegaly, and cavernous transformation of the portal vein successfully managed through splenectomy and spleno-renal shunt. A 30-year-old female with a history of portal hypertension, portal gastropathy, and splenomegaly presented with left upper quadrant abdominal pain. She had previously undergone esophageal variceal ligation and required intermittent blood transfusions. Additional complications included easy bruising, heavy menstrual bleeding, and a prior episode of hematemesis. Clinical assessment confirmed splenomegaly, while a CT scan confirmed the diagnosis. A tailored surgical approach was chosen, leading to splenectomy and spleno-renal shunt.<\/jats:p>","DOI":"10.1093\/jscr\/rjad607","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T17:26:06Z","timestamp":1701969966000},"source":"Crossref","is-referenced-by-count":1,"title":["Successful management of portal hypertension with splenomegaly and cavernous transformation of the portal vein: a rare case report"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1472-3714","authenticated-orcid":false,"given":"Simrah","family":"Sharjeel","sequence":"first","affiliation":[{"name":"Medicine, Jinnah Sindh Medical University , Karachi , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Abdullah","sequence":"additional","affiliation":[{"name":"General Surgery, Indus Hospital and Health Network , Karachi , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"2023120714095194600_ref1","article-title":"Portal hypertension in cirrhosis: pathophysiological mechanisms and therapy","volume":"3","author":"Iwakiri","year":"2021","journal-title":"JHEP Rep"},{"key":"2023120714095194600_ref2","article-title":"Optimal treatment for patients with cavernous transformation of the portal vein","volume":"9","author":"Wei","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"2023120714095194600_ref3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijsu.2020.10.034","article-title":"The SCARE Guideline: updating consensus surgical CAse REport (SCARE) guidelines","volume":"84","author":"Agha","year":"2020","journal-title":"Int J Surg"},{"key":"2023120714095194600_ref4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4103\/1319-3767.157550","article-title":"Extrahepatic portal vein obstruction and portal vein thrombosis in special situations: need for a new classification","volume":"21","author":"Wani","year":"2015","journal-title":"Saudi J Gastroenterol"},{"key":"2023120714095194600_ref5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/jamasurg.2013.4045","article-title":"Fifty-three years' experience with randomized clinical trials of emergency portacaval shunt for bleeding esophageal varices in cirrhosis: 1958\u20132011","volume":"149","author":"Orloff","year":"2014","journal-title":"JAMA Surg"},{"key":"2023120714095194600_ref6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11894-020-00792-0","article-title":"Causes and management of non-cirrhotic portal hypertension","volume":"22","author":"Gioia","year":"2020","journal-title":"Curr Gastroenterol Rep"},{"key":"2023120714095194600_ref7","doi-asserted-by":"crossref","first-page":"bcr2013200222","DOI":"10.1136\/bcr-2013-200222","article-title":"Portal pyaemia secondary to open haemorrhoidectomy: need for prophylactic broad spectrum antibiotics","volume":"2013","author":"Prabhu","year":"2013","journal-title":"BMJ Case Rep"},{"key":"2023120714095194600_ref8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1477-2574.2010.00232.x","article-title":"Portal biliopathy: a study of 39 surgically treated patients","volume":"13","author":"Agarwal","year":"2011","journal-title":"HPB (Oxford)"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/12\/rjad607\/54036194\/rjad607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2023\/12\/rjad607\/54036194\/rjad607.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T17:26:10Z","timestamp":1701969970000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjad607\/7459588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjad607","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,12]]},"article-number":"rjad607"}}