{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:17Z","timestamp":1753877237915,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN) is a rare spectrum of acute, mucocutaneous drug reactions characterized by epidermal necrosis of the skin and mucous membranes with progressive multiorgan failure. Cutaneous presentation of SJS\/TEN is similar to that of acute graft-versus-host disease, creating a diagnostic dilemma in solid-organ transplant recipients presenting with diffuse, erythematous eruptions, skin sloughing, and systemic sequelae, reflective of both diseases. This case report details a 48-year-old woman post-orthotopic liver transplantation (OLT) who developed a diffuse, painful, morbilliform rash with progressive desquamation, along with corresponding pathological analysis indicative of SJS\/TEN. There are few documented reports of SJS\/TEN in solid-organ transplant recipients, and this case illustrates successful intervention and resolution of SJS\/TEN in an OLT recipient while managing intraabdominal sepsis and an episode of acute rejection. Despite its rarity, prompt diagnosis of SJS\/TEN and the implementation of tailored therapeutic strategies are crucial in the care of solid-organ transplant recipients.<\/jats:p>","DOI":"10.1093\/jscr\/rjad739","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T17:25:01Z","timestamp":1705598701000},"source":"Crossref","is-referenced-by-count":1,"title":["Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis in an orthotopic liver transplant recipient: a case report"],"prefix":"10.1093","volume":"2024","author":[{"given":"Chun-Sing","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Abdominal Transplantation , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"},{"name":"Baylor College of Medicine , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3967-8500","authenticated-orcid":false,"given":"Emily","family":"Strouphauer","sequence":"additional","affiliation":[{"name":"School of Medicine, Baylor College of Medicine , 1 Baylor Plaza, Houston, TX , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"O\u2019Mahony","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"},{"name":"Baylor College of Medicine , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhu T N","family":"Galv\u00e1n","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"},{"name":"Baylor College of Medicine , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Cotton","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"},{"name":"Baylor College of Medicine , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Goss","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"},{"name":"Baylor College of Medicine , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"},{"name":"Baylor College of Medicine , Michael E. DeBakey Department of General Surgery, , Houston, TX , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"2024011817243401000_ref1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jaip.2014.10.002","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: a cross-sectional analysis of patients in an integrated allergy repository of a large health care system","volume":"3","author":"Blumenthal","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"volume-title":"StatPearls","year":"2022","author":"Oakley","key":"2024011817243401000_ref2"},{"volume-title":"Merck Manuals Professional Edition","author":"Benedetti","key":"2024011817243401000_ref3"},{"key":"2024011817243401000_ref4"},{"key":"2024011817243401000_ref5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1750-1172-5-39","article-title":"Toxic epidermal necrolysis and Stevens-Johnson syndrome","volume":"5","author":"Harr","year":"2010","journal-title":"Orphanet J Rare Dis"},{"journal-title":"Pathophysiology","article-title":"Stevens-Johnson Syndrome: practice essentials, background","author":"Foster","key":"2024011817243401000_ref6"},{"key":"2024011817243401000_ref7","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/lt.21203","article-title":"Graft vs. host disease after liver transplantation: a new approach is needed","volume":"13","author":"Perri","year":"2007","journal-title":"Liver Transpl"},{"key":"2024011817243401000_ref8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1399-3062.2012.00746.x","article-title":"Graft-versus-host disease or toxic epidermal necrolysis: diagnostic dilemma after liver transplantation","volume":"14","author":"Jeanmonod","year":"2012","journal-title":"Transpl Infect Dis"},{"key":"2024011817243401000_ref9","first-page":"e1","article-title":"Severe desquamating disorder after liver transplant","volume":"5","author":"Schulz","year":"2006","journal-title":"J Burns Wounds"},{"key":"2024011817243401000_ref10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fimmu.2022.917782","article-title":"Diagnostic and therapeutic dilemma in Stevens\u2013Johnson syndrome-like acute graft-versus-host disease after liver transplantation: a case report","volume":"13","author":"Hung","year":"2022","journal-title":"Front Immunol"},{"key":"2024011817243401000_ref11","first-page":"8981429","article-title":"Treatment of acute graft-versus-host disease in liver transplant recipients","volume":"2021","author":"Kim","year":"2021","journal-title":"Case Rep Transplant"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/1\/rjad739\/56149739\/rjad739.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/1\/rjad739\/56149739\/rjad739.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T17:25:09Z","timestamp":1705598709000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjad739\/7560338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjad739","relation":{},"ISSN":["2042-8812"],"issn-type":[{"type":"electronic","value":"2042-8812"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2024,1]]},"article-number":"rjad739"}}