{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:18Z","timestamp":1753877238166,"version":"3.41.2"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"International Science and Technology Innovation Cooperation Project of Sichuan Province","award":["22GJHZ0278"],"award-info":[{"award-number":["22GJHZ0278"]}]},{"name":"Sichuan Science and Technology Program","award":["2022YFS0614"],"award-info":[{"award-number":["2022YFS0614"]}]},{"name":"Medical Research Project of Sichuan Province","award":["S21020"],"award-info":[{"award-number":["S21020"]}]},{"name":"Science and Technology Strategic Cooperation Project of Luzhou Municipal People's Government"},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2021LZXNYD-D10"],"award-info":[{"award-number":["2021LZXNYD-D10"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Doctoral Research Initiation Program of the Affiliated Hospital of Southwest Medical University","award":["19041"],"award-info":[{"award-number":["19041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cutaneous mucormycosis with ischemic complications is a life-threatening condition with high mortality rates, particularly in immunocompromised individuals. The incidence of mucormycosis has increased during the COVID-19 pandemic due to reduced immunity. We present the case of a 17-year-old high school student who experienced a sprained left lower extremity, followed by worsening pain and swelling due to the topical application of unknown local herbs. Eighteen days after the injury, she was admitted to our department in a comatose state with left lower limb ischemia. The patient had a history of uncontrolled diabetes mellitus and displayed a necrotic lesion on her left ankle, suggestive of invasive infectious fungi disease. Diagnostic procedures, including tissue staining and molecular analysis, identified Rhizopus oryzae as the causative organism. Administering amphotericin B yielded marked improvement, but the patient necessitated a mid-thigh amputation to curtail the infection\u2019s advance, culminating in her successful discharge post-treatment.<\/jats:p>","DOI":"10.1093\/jscr\/rjae003","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T03:29:07Z","timestamp":1707362947000},"source":"Crossref","is-referenced-by-count":0,"title":["A 17-year-old student with ankle sprain to leg amputation"],"prefix":"10.1093","volume":"2024","author":[{"given":"Xi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University , Luzhou 646000 , China"},{"name":"Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou , Luzhou 646000, Sichuan , China"},{"name":"Key Laboratory of Medical Electrophysiology , Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, , Luzhou 646000, Sichuan , China"},{"name":"Southwest Medical University , Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, , Luzhou 646000, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinhuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University , Luzhou 646000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University , Luzhou 646000 , China"},{"name":"Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou , Luzhou 646000, Sichuan , China"},{"name":"Key Laboratory of Medical Electrophysiology , Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, , Luzhou 646000, Sichuan , China"},{"name":"Southwest Medical University , Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, , Luzhou 646000, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixue","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University , Luzhou 646000 , China"},{"name":"Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou , Luzhou 646000, Sichuan , China"},{"name":"Key Laboratory of Medical Electrophysiology , Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, , Luzhou 646000, Sichuan , China"},{"name":"Southwest Medical University , Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, , Luzhou 646000, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Vascular Surgery), The Affiliated Hospital of Southwest Medical University , Luzhou 646000 , China"},{"name":"Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou , Luzhou 646000, Sichuan , China"},{"name":"Key Laboratory of Medical Electrophysiology , Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, , Luzhou 646000, Sichuan , China"},{"name":"Southwest Medical University , Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, , Luzhou 646000, Sichuan , China"},{"name":"Department of Interventional Medicine, The Affiliated Hospital of Southwest Medical University , Luzhou 646000 , China"},{"name":"Nucleic Acid Medicine of Luzhou Key Laboratory, Southwest Medical University , Luzhou 646000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"2024020803273693400_ref1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/lio2.899","article-title":"Mucormycosis in pre-COVID-19 and COVID-19 era: a study of prevalence, risk factors and clinical features","volume":"7","author":"Arjmand","year":"2022","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"2024020803273693400_ref2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/ijciis.ijciis_48_21","article-title":"Storm of a rare opportunistic life threatening mucormycosis among post COVID-19 patients: a tale of two pathogens","volume":"12","author":"Sannathimmappa","year":"2022","journal-title":"Int J Crit Illn Inj Sci"},{"key":"2024020803273693400_ref3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/jof5030057","article-title":"Necrotizing mucormycosis of wounds following combat injuries, natural disasters, burns, and other trauma","volume":"5","author":"Walsh","year":"2019","journal-title":"J Fungi (Basel)"},{"key":"2024020803273693400_ref4","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/IAI.73.2.778-783.2005","article-title":"Rhizopus oryzae adheres to, is phagocytosed by, and damages endothelial cells in vitro","volume":"73","author":"Ibrahim","year":"2005","journal-title":"Infect Immun"},{"key":"2024020803273693400_ref5","doi-asserted-by":"crossref","DOI":"10.1016\/j.dsx.2021.05.019","article-title":"Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India","volume":"15","author":"Singh","year":"2021","journal-title":"Diabetes Metab Syndr"},{"key":"2024020803273693400_ref6","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/tmi.13641","article-title":"COVID-19 and mucormycosis syndemic: double health threat to a collapsing healthcare system in India","volume":"26","author":"Rocha","year":"2021","journal-title":"Trop Med Int Health"},{"key":"2024020803273693400_ref7","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat Med"}],"container-title":["Journal of Surgical Case 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