{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:53:21Z","timestamp":1774479201841,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Haemobilia, or bleeding within the biliary tree, is rare. It can cause biliary obstruction secondary to blood clots. A comorbid 87-year-old was admitted to hospital with acute cholecystitis, choledocholithiasis, and an Escherichia coli bacteremia. He had a partial pancreatectomy and gastrojejunostomy 35\u00a0years prior for severe pancreatitis. He was treated with antibiotics and a percutaneous cholecystostomy. He developed atrial fibrillation and was subsequently commenced on warfarin. He re-presented 5 days after discharge with abdominal pain and fevers. Liver function tests revealed cholestasis and a supratherapeutic international normalised ratio. Imaging showed cholecystitis, biliary obstruction, and extensive biliary blood clots. He improved with antibiotics, vitamin K, and alteplase flushes through the percutaneous cholecystostomy. Repeat cholangiogram demonstrated dissolution of the biliary clots. Due to altered anatomy and comorbidities, alteplase flushes were utilized to relieve this patient\u2019s biliary obstruction. Thrombolytics may assist in treating biliary clots when first-line options are not possible or favourable.<\/jats:p>","DOI":"10.1093\/jscr\/rjae055","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T07:21:40Z","timestamp":1708672900000},"source":"Crossref","is-referenced-by-count":3,"title":["Percutaneous thrombolysis via cholecystostomy catheter to dissolve biliary clots causing obstructive jaundice"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3072-4494","authenticated-orcid":false,"given":"Sonya A","family":"Smith","sequence":"first","affiliation":[{"name":"Department of General Surgery, The Prince Charles Hospital , 627 Rode Rd, Chermside QLD0, Queensland 4032 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fraser","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Prince Charles Hospital , 627 Rode Rd, Chermside QLD0, Queensland 4032 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Bell-Allen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Prince Charles Hospital , 627 Rode Rd, Chermside QLD0, Queensland 4032 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Prince Charles Hospital , 627 Rode Rd, Chermside, Queensland 4032 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjivan","family":"Mudaliar","sequence":"additional","affiliation":[{"name":"Department of Gastroentrology, The Prince Charles Hospital , 627 Rode Rd, Chermside, Queensland 4032 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khurram","family":"Aftab","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Prince Charles Hospital , 627 Rode Rd, Chermside, Queensland 4032 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Prince Charles Hospital , 627 Rode Rd, Chermside QLD0, Queensland 4032 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manju D","family":"Chandrasegaram","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Prince Charles Hospital , 627 Rode Rd, Chermside QLD0, Queensland 4032 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"2024022307212849000_ref1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.livres.2018.09.007","article-title":"Hemobilia: Etiology, diagnosis, and treatment","volume":"2","author":"Berry","year":"2018","journal-title":"Liver Res"},{"key":"2024022307212849000_ref2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1046\/j.1365-2168.2001.01756.x","article-title":"Haemobilia","volume":"88","author":"Green","year":"2001","journal-title":"Br J Surg"},{"key":"2024022307212849000_ref3","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00000658-197908000-00020","article-title":"M. Clinical significance and pathophysiological background","volume":"190","author":"Sandblom","year":"1979","journal-title":"Ann Surg"},{"key":"2024022307212849000_ref4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11894-021-00808-3","article-title":"Review of ERCP techniques in roux-en-Y gastric bypass patients: highlight on the novel EUS-directed transgastric ERCP (EGDE) technique","volume":"23","author":"Khara","year":"2021","journal-title":"Curr Gastroenterol Rep"},{"key":"2024022307212849000_ref5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3324\/haematol.2011.050492","article-title":"Thrombolytic therapy for central venous catheter occlusion","volume":"97","author":"Baskin","year":"2012","journal-title":"Haematologica"},{"key":"2024022307212849000_ref6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"key":"2024022307212849000_ref7","first-page":"186","article-title":"Update on thrombolytic therapy in acute pulmonary thromboembolism","volume":"51","author":"Ucar","year":"2019","journal-title":"Eurasian J Med"},{"key":"2024022307212849000_ref8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0016-5107(02)70057-6","article-title":"Dissolution of blood clots in the biliary ducts with a thrombolytic agent infused through nasobiliary catheter","volume":"56","author":"Moparty","year":"2002","journal-title":"Gastrointest Endosc"},{"key":"2024022307212849000_ref9","doi-asserted-by":"crossref","first-page":"107273","DOI":"10.1016\/j.ijscr.2022.107273","article-title":"Acute cholangitis due to haemobilia complicating percutaneous cholecystostomy: first literature case report","volume":"96","author":"Beji","year":"2022","journal-title":"Int J Surg Case Rep"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/2\/rjae055\/56741961\/rjae055.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/2\/rjae055\/56741961\/rjae055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T07:21:47Z","timestamp":1708672907000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae055\/7612642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae055","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2024,2]]},"article-number":"rjae055"}}