{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:30:18Z","timestamp":1789993818688,"version":"4.0.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Department of Otolaryngology"},{"name":"University of Iowa Hospitals and Clinics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chlorhexidine (CHD) is commonly included in surgical antiseptics and can be associated with adverse reactions ranging from contact dermatitis to anaphylaxis. A 32-year-old female presented to the OR for facial fat grafting. Surgical sites were prepped with CHD gluconate or topical iodine. Donor and recipient sites were infiltrated with local anesthetic injection prior to fat harvest and facial injection. Eleven days later, she presented with new painful, pruritic rash over donor sites where CHD had been applied prior to local anesthetic infiltration. Treatment with topical clobetasol and prednisone taper resulted in complete symptom resolution. This patient\u2019s response most likely represented a delayed type IV, T-cell mediated hypersensitivity. CHD is a known trigger of allergic reactions. Infiltration of local anesthetic may introduce skin prep into the subcutaneous tissue akin to intradermal testing. For those with delayed cutaneous reactions, steroids may provide symptomatic relief.<\/jats:p>","DOI":"10.1093\/jscr\/rjae103","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T07:53:06Z","timestamp":1720252386000},"source":"Crossref","is-referenced-by-count":4,"title":["Cutaneous hypersensitivity to chlorhexidine following facial fat grafting: a delayed intradermal response"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6955-797X","authenticated-orcid":false,"given":"Brady J","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics , Iowa City, IA 52242, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary G","family":"Tanenbaum","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics , Iowa City, IA 52242, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Michael","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics , Iowa City, IA 52242, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics , Iowa City, IA 52242, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,6]]},"reference":[{"key":"2024070607525806500_ref1","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1097\/01.prs.0000260712.44089.e7","article-title":"Autologous fat transfer for facial recontouring: is there science behind the art?","volume":"119","author":"Kaufman","year":"2007","journal-title":"Plast 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