{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:02:18Z","timestamp":1777352538790,"version":"3.51.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tooth loss often leads to significant alveolar bone resorption, presenting a challenge for dental implant placement. This case report presents the effectiveness of concentrated platelet-rich fibrin (C-PRF) in combination with bone allograft for horizontal bone augmentation in a severely atrophic maxilla. A 33-year-old female patient with extensive bone loss in the upper anterior maxilla was treated in two stages. The initial stage involved horizontal bone augmentation using a mixture of C-PRF and bone allograft. This was followed, 5\u00a0months later, by dental implant placement. The preparation of C-PRF, surgical procedure, and postoperative care are thoroughly described. Post-treatment Cone Beam Computed Tomography showed an increase in alveolar bone thickness from 2.4\u20133.4\u00a0mm pre-operatively to 6.3\u20137.3\u00a0mm, demonstrating the procedure\u2019s effectiveness in achieving adequate bone volume for implant placement. The use of C-PRF with allograft in horizontal bone augmentation shows promise in enhancing bone regeneration, especially in a severely atrophic maxilla.<\/jats:p>","DOI":"10.1093\/jscr\/rjae165","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T05:41:00Z","timestamp":1710826860000},"source":"Crossref","is-referenced-by-count":3,"title":["Management of a severely atrophic maxilla using concentrated platelet-rich fibrin block. A case report"],"prefix":"10.1093","volume":"2024","author":[{"given":"Raghad N","family":"Saleh","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Surgery Department, University College London , London EC4N 1SA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"Ashhab","sequence":"additional","affiliation":[{"name":"Graduate Studies, Arab American University , Ramallah 00970 , Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meral Voltaire","family":"Kharoufeh","sequence":"additional","affiliation":[{"name":"Periodontics Department, Al-Quds University , Jerusalem 00970 , Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cezar Edward","family":"Lahham","sequence":"additional","affiliation":[{"name":"Periodontics Department, Arab American University , Bethlehem 00970 , Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,17]]},"reference":[{"key":"2024031904424752800_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0501.2011.02375.x","article-title":"A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans","volume":"23","author":"Tan","year":"2012","journal-title":"Clin Oral Implants Res"},{"key":"2024031904424752800_ref2","first-page":"304","article-title":"Ridge preservation: important buzzwords in dentistry","volume":"48","author":"Ashman","year":"2000","journal-title":"Gen Dent"},{"key":"2024031904424752800_ref3","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jbm.a.34812","article-title":"Vertical bone augmentation procedures: basics and techniques in dental implantology","volume":"102","author":"Draenert","year":"2014","journal-title":"J Biomed Mater Res Part A"},{"key":"2024031904424752800_ref4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1600-0757.2011.00432.x","article-title":"Advanced reconstructive technologies for periodontal tissue repair","volume":"59","author":"Ramseier","year":"2020","journal-title":"Periodontol 2000"},{"key":"2024031904424752800_ref5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/eos.12364","article-title":"Guided bone regeneration: materials and biological mechanisms revisited","volume":"125","author":"Elgali","year":"2017","journal-title":"Eur J Oral Sci"},{"key":"2024031904424752800_ref6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.12998\/wjcc.v5.i5.159","article-title":"Evolution, current status and advances in application of platelet concentrate in periodontics and implantology","volume":"5","author":"Agrawal","year":"2017","journal-title":"World J Clin Cases"},{"key":"2024031904424752800_ref7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.actbio.2018.05.021","article-title":"Autologous liquid platelet rich fibrin: a novel drug delivery system","volume":"75","author":"Miron","year":"2018","journal-title":"Acta Biomater"},{"key":"2024031904424752800_ref8","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.injury.2005.07.019","article-title":"Current concepts of molecular aspects of bone healing","volume":"36","author":"Dimitriou","year":"2005","journal-title":"Injury"},{"key":"2024031904424752800_ref9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1186\/s12903-023-03400-5","article-title":"The effect of recurrent application of concentrated platelet-rich fibrin inside the extraction socket on the hard and soft tissues. A randomized controlled trial","volume":"23","author":"Lahham","year":"2023","journal-title":"BMC Oral Health"},{"key":"2024031904424752800_ref10","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1515\/med-2021-0259","article-title":"Platelet-rich fibrin: basics of biological actions and protocol modifications","volume":"16","author":"Pavlovic","year":"2021","journal-title":"Open Med (Wars)"},{"key":"2024031904424752800_ref11","first-page":"112557","article-title":"The feasibility of injectable PRF (I-PRF) for bone tissue engineering and its application in oral and maxillofacial reconstruction: from bench to chairside","volume":"134","author":"Farshidfar","year":"2021","journal-title":"Mater Sci Eng C"},{"key":"2024031904424752800_ref12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s40729-020-00266-y","article-title":"Guided bone regeneration in staged vertical and horizontal bone augmentation using platelet-rich fibrin associated with bone grafts: a retrospective clinical study","volume":"6","author":"Amaral Vallad\u00e3o","year":"2020","journal-title":"Int J Implant Dent"},{"key":"2024031904424752800_ref13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1563\/AAID-JOI-D-14-00023","article-title":"Classification of the alveolar ridge width: implant-driven treatment considerations for the horizontally deficient alveolar ridges","volume":"40","author":"Tolstunov","year":"2014","journal-title":"J Oral Implantol"},{"key":"2024031904424752800_ref14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/clr.17_13356","article-title":"L-PRF block for horizontal bone augmentation, clinical results and histology- a prospective case series","volume":"29","author":"Cortellini","year":"2018","journal-title":"Clin Oral Implants Res"},{"key":"2024031904424752800_ref15","article-title":"Volumetric CBCT evaluation of sticky bone (ABBM+ i-PRF) in horizontal ridge augmentation - a case series","volume":"13","author":"Parthasarathy","year":"2022","journal-title":"J Pharm Negat Results"},{"key":"2024031904424752800_ref16","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1034\/j.1600-051x.2000.027012889.x","article-title":"A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans","volume":"27","author":"Camargo","year":"2000","journal-title":"J Clin Periodontol"},{"key":"2024031904424752800_ref17","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1007\/s00784-020-03303-7","article-title":"Improved growth factor delivery and cellular activity using concentrated platelet-rich fibrin (C-PRF) when compared with traditional injectable (i-PRF) protocols","volume":"24","author":"Fujioka-Kobayashi","year":"2020","journal-title":"Clin Oral Investig"},{"key":"2024031904424752800_ref18","doi-asserted-by":"crossref","DOI":"10.3390\/ma15041474","article-title":"Sticky bone preparation device: a pilot study on the release of cytokines and growth factors","volume":"15","author":"Gheno","year":"2022","journal-title":"Materials (Basel)"},{"key":"2024031904424752800_ref19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.21608\/dsu.2021.64004.1066","article-title":"Effect of injectable-platelet rich fibrin on marginal adaptation of bioactive materials used as direct pulp capping; an experimental animal study","volume":"2","author":"Mansour","year":"2021","journal-title":"Dent Sci Updat"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/3\/rjae165\/56996178\/rjae165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/3\/rjae165\/56996178\/rjae165.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T05:41:10Z","timestamp":1710826870000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae165\/7630544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae165","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2024,3]]},"article-number":"rjae165"}}