{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:08:19Z","timestamp":1753877299131,"version":"3.41.2"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pneumoperitoneum in patients with systemic lupus erythematosus is commonly recognized as a surgical emergency that requires exploration. However, it may not be associated with bowel perforation and may be a benign disease manifestation. We present a case of a young patient who developed spontaneous pneumoperitoneum after pulse steroid therapy for lupus enteritis and was successfully managed conservatively. Patients with connective tissue disease may present with pneumoperitoneum, with or without pneumatosis cystoides intestinalis. Therefore, a detailed clinical history, thorough clinical examination, and laboratory parameters should be evaluated before proceeding with surgical intervention. A conservative approach may be attempted in patients with spontaneous pneumoperitoneum, and surgery should only be considered if clinical deterioration occurs.<\/jats:p>","DOI":"10.1093\/jscr\/rjae182","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:29:01Z","timestamp":1711600141000},"source":"Crossref","is-referenced-by-count":1,"title":["Systemic lupus erythematosus presenting with pneumoperitoneum without evidence of pneumatosis cystoides intestinalis\u2014when not to operate\u2014a case report"],"prefix":"10.1093","volume":"2024","author":[{"given":"Wafa","family":"Iftekhar","sequence":"first","affiliation":[{"name":"Aga Khan University Hospital Department of General Surgery, , Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7881-8748","authenticated-orcid":false,"given":"Hafsa","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital Department of General Surgery, , Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul R","family":"Alvi","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital Department of General Surgery, , Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"2024032804281726400_ref1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/s00261-014-0110-4","article-title":"From esophagus to rectum: a comprehensive review of alimentary tract perforations at computed tomography","volume":"39","author":"Del Gaizo","year":"2014","journal-title":"Abdom Imaging"},{"key":"2024032804281726400_ref2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jmau.2016.04.004","article-title":"The pattern of causes of pneumoperitoneum-induced peritonitis: results of an empirical study","volume":"5","author":"Makki","year":"2017","journal-title":"J Microsc Ultrastruct"},{"key":"2024032804281726400_ref3","first-page":"e93750","article-title":"Asymptomatic spontaneous pneumoperitoneum","author":"Kadkhodaie","year":"2008"},{"key":"2024032804281726400_ref4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/pgmj.73.863.531","article-title":"Spontaneous pneumoperitoneum and other nonsurgical causes of intraperitoneal free gas","volume":"73","author":"Williams","year":"1997","journal-title":"Postgrad Med J"},{"key":"2024032804281726400_ref5","doi-asserted-by":"crossref","first-page":"bcr2014207234","DOI":"10.1136\/bcr-2014-207234","article-title":"Pneumatosis intestinalis an increasingly common radiological finding, benign or life-threatening? 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operate","volume":"4","author":"Quach","year":"2019","journal-title":"Int J Case Rep"},{"key":"2024032804281726400_ref17","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1016\/j.radcr.2020.09.034","article-title":"Pneumatosis intestinalis with pneumoperitoneum: not always a surgical emergency","volume":"15","author":"Than","year":"2020","journal-title":"Radiol Case Rep"},{"key":"2024032804281726400_ref18","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00296-022-05205-1","article-title":"Pneumomediastinum, pneumatosis intestinalis and pneumoperitoneum in a patient with polymyositis: case-based review","volume":"43","author":"Dilbil","year":"2023","journal-title":"Rheumatol Int"},{"key":"2024032804281726400_ref19","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.18203\/2320-6012.ijrms20212795","article-title":"Spontaneous pneumoperitoneum secondary to intestinal pneumatosis: an uncommon cause of acute 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