{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:44:29Z","timestamp":1790790269432,"version":"4.1.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Systemic amyloidosis is an incurable multisystem disease, caused by fibrillar protein deposits with resulting dysfunction of affected organ systems. It mostly affects patients &amp;gt; 60\u00a0years. Diagnosis is often delayed because the symptoms are nonspecific and highly variable. We report on an elderly patient with multi-organ involvement with proven wild-type transthyretin amyloidosis. The initial manifestation involved bilateral carpal tunnel syndrome and lumbar spinal canal stenosis. The occurrence of ligament and tendon disorders, unexplained muscle pain and polyneuropathy in elderly patients should be considered as a possible first manifestation of systemic amyloidosis.<\/jats:p>","DOI":"10.1093\/jscr\/rjae183","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:29:46Z","timestamp":1711600186000},"source":"Crossref","is-referenced-by-count":3,"title":["Carpal tunnel syndrome, spinal canal stenosis, cardiomyopathy, renal insufficiency, enteropathy, and diffuse myopathy as an expression of systemic ATTR amyloidosis - diagnostics and therapy"],"prefix":"10.1093","volume":"2024","author":[{"given":"Sebastian","family":"Radmer","sequence":"first","affiliation":[{"name":"Centre for Orthopaedics , Bozener Str. 17, 10825 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1385-2793","authenticated-orcid":false,"given":"Julian Ramin","family":"Andresen","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Orthopedics and Trauma Surgery, , Waehringer Guertel 18-20, Vienna 1090, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"2024032804293422200_ref1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1182\/blood-2016-01-629790","article-title":"What is new in diagnosis and management of light chain amyloidosis?","volume":"128","author":"Palladini","year":"2016","journal-title":"Blood"},{"key":"2024032804293422200_ref2","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/eurheartj\/ehv338","article-title":"Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction","volume":"36","author":"Gonzalez-Lopez","year":"2015","journal-title":"Eur Heart J"},{"key":"2024032804293422200_ref3","doi-asserted-by":"crossref","first-page":"101667","DOI":"10.1016\/j.cpcardiol.2023.101667","article-title":"Real-world efficacy of tafamidis in patients with transthyretin amyloidosis and heart failure","volume":"48","author":"Ghoneem","year":"2023","journal-title":"Curr Probl Cardiol"},{"key":"2024032804293422200_ref4","first-page":"159","article-title":"Amyloidosis - the diagnosis and treatment of an underdiagnosed disease","volume":"117","author":"Ihne","year":"2020","journal-title":"Dtsch Arztebl Int"},{"key":"2024032804293422200_ref5","first-page":"329","article-title":"Carpal tunnel syndrome and ATTR-amyloidosis","volume":"50","author":"Hahn","year":"2018","journal-title":"Handchir Mikrochir Plast Chir"},{"key":"2024032804293422200_ref6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/ejhf.1742","article-title":"Carpal tunnel syndrome in cardiac amyloidosis: implications for early diagnosis and prognostic role across the spectrum of aetiologies","volume":"22","author":"Milandri","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"2024032804293422200_ref7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1080\/13506129.2021.1950681","article-title":"Association between spinal stenosis and wild-type ATTR amyloidosis","volume":"28","author":"Godara","year":"2021","journal-title":"Amyloid"},{"key":"2024032804293422200_ref8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jjcc.2023.04.019","article-title":"Clinical characteristics and prognostic implications of orthopedic ligament disorders in patients with wild-type transthyretin amyloidosis cardiomyopathy","volume":"82","author":"Klarskov","year":"2023","journal-title":"J Cardiol"},{"key":"2024032804293422200_ref9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.14797\/mdcvj.1163","article-title":"Opportunities for earlier diagnosis and treatment of cardiac amyloidosis","volume":"18","author":"Martyn","year":"2022","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"2024032804293422200_ref10","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/ehjci\/jeab226","article-title":"Tafamidis treatment delays structural and functional changes of the left ventricle in patients with transthyretin amyloid cardiomyopathy","volume":"23","author":"Rettl","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2024032804293422200_ref11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/13506129.2022.2131385","article-title":"Impact of tafamidis on myocardial strain in transthyretin amyloid cardiomyopathy","volume":"30","author":"Rettl","year":"2023","journal-title":"Amyloid"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/3\/rjae183\/57099534\/rjae183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/3\/rjae183\/57099534\/rjae183.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:29:52Z","timestamp":1711600192000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae183\/7635882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae183","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2024,3]]},"article-number":"rjae183"}}