{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:03:53Z","timestamp":1787670233801,"version":"build-2736575974"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Skull base osteomyelitis is a rare and life-threatening infection of the skull base, commonly seen in elderly diabetic patients as a result of otogenic or paranasal infection. The diagnosis is based on a series of arguments, including a high clinical suspicion, imaging findings, negative biopsies for malignancy, and microbiological isolation. Complications, including abscess formation and vascular involvement, mandate a multidisciplinary treatment approach, primarily involving broad-spectrum antibiotics and surgical debridement, but the prognosis is usually poor. Herein, we describe the case of a 55-year-old male, who 15\u00a0years prior, underwent radiation therapy for nasopharyngeal carcinoma. He presented with an infection of the skull base with extensive bone erosion accompanied by an uncommon complication; an intra clival abscess. Despite aggressive antibiotic therapy, the patient ultimately succumbed to septic shock.<\/jats:p>","DOI":"10.1093\/jscr\/rjae282","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T09:53:11Z","timestamp":1714729991000},"source":"Crossref","is-referenced-by-count":6,"title":["Navigating the complexity of skull base osteomyelitis: a case study and comprehensive review"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-6949","authenticated-orcid":false,"given":"Kenza","family":"Horache","sequence":"first","affiliation":[{"name":"Neuroradiology Department, Specialty Hospital of Rabat , Rue Lamfadel Cherkaoui Rabat - Institut B.P 6527 , Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Jidal","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Specialty Hospital of Rabat , Rue Lamfadel Cherkaoui Rabat - Institut B.P 6527 , Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najwa El","family":"Kettani","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Specialty Hospital of Rabat , Rue Lamfadel Cherkaoui Rabat - Institut B.P 6527 , Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Fikri","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Specialty Hospital of Rabat , Rue Lamfadel Cherkaoui Rabat - Institut B.P 6527 , Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Jiddane","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Specialty Hospital of Rabat , Rue Lamfadel Cherkaoui Rabat - Institut B.P 6527 , Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdaous","family":"Touarsa","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Specialty Hospital of Rabat , Rue Lamfadel Cherkaoui Rabat - Institut B.P 6527 , Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"2024050309515134200_ref1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1148\/rg.2021200046","article-title":"Diagnosis of skull base osteomyelitis","volume":"41","author":"\u00c1lvarez J\u00e1\u00f1ez","year":"2021","journal-title":"Radiographics"},{"key":"2024050309515134200_ref2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1055\/s-0034-1372468","article-title":"Osteomyelitis of the temporal bone: terminology, diagnosis, and management","volume":"75","author":"Prasad","year":"2014","journal-title":"J Neurol Surg B Skull Base"},{"key":"2024050309515134200_ref3","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/lary.24440","article-title":"Central skull base osteomyelitis: an emerging clinical entity","volume":"124","author":"Johnson","year":"2014","journal-title":"Laryngoscope"},{"key":"2024050309515134200_ref4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11060-020-03462-3","article-title":"Osteoradionecrosis of the skull base","volume":"150","author":"Leonetti","year":"2020","journal-title":"J Neurooncol"},{"key":"2024050309515134200_ref5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13256-017-1221-7","article-title":"Severe skull base osteomyelitis caused by Pseudomonas aeruginosa with successful outcome after prolonged outpatient therapy with continuous infusion of ceftazidime and oral ciprofloxacin: a case report","volume":"11","author":"Conde-D\u00edaz","year":"2017","journal-title":"J Med Case Rep"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/5\/rjae282\/57388506\/rjae282.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2024\/5\/rjae282\/57388506\/rjae282.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T09:53:15Z","timestamp":1714729995000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjae282\/7661459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjae282","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,5]]},"article-number":"rjae282"}}