{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:50:39Z","timestamp":1760986239973,"version":"3.41.2"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The recurrence rate following thymoma surgery has been reported to be as high as 29%. In cases of localized recurrence, complete resection can result in prolonged patient survival. However, surgery is rarely considered in cases of invasive recurrent thymomas with high disease burden. Here, we present the case of a woman with type B2 thymoma (Masaoka\u2013Koga stage IVa) treated with surgery, chemotherapy, and radiotherapy. The disease recurred 6 years later, with invasion of the left lung and the 12th thoracic vertebra, as well as extension into the retroperitoneum. Due to the development of chemotherapy-associated toxicity, she underwent surgery with complete tumor resection and has remained free of disease at a 12-months follow-up. Radical surgery for recurrent invasive thymoma extending through the diaphragm is a feasible and safe therapeutic option in highly selected patients who are not eligible for systemic treatments.<\/jats:p>","DOI":"10.1093\/jscr\/rjae288","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T05:31:02Z","timestamp":1714973462000},"source":"Crossref","is-referenced-by-count":2,"title":["Salvage surgery for recurrent transdiaphragmatic thymoma in a patient not eligible for chemotherapy"],"prefix":"10.1093","volume":"2024","author":[{"given":"Giulia","family":"Fabbri","sequence":"first","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust Department of Thoracic Surgery, , Great Maze Pond, London SE1 9RT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabih","family":"Berjaoui","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust Department of Thoracic Surgery, , Great Maze Pond, London SE1 9RT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savvas","family":"Lampridis","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust Department of Thoracic Surgery, , Great Maze Pond, London SE1 9RT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajdeep","family":"Bilkhu","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust Department of Cardiac Surgery, , London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishaan","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust Department of Thoracic Surgery, , Great Maze Pond, London SE1 9RT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ee Phui","family":"Kew","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust Department of Thoracic Surgery, , Great Maze Pond, London SE1 9RT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshay","family":"Patel","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust Department of Thoracic Surgery, , Great Maze Pond, London SE1 9RT, United Kingdom"},{"name":"University of Birmingham, Vincent Drive, Edgbaston Institute of Immunology and Immunotherapy, , Birmingham, B15 2TT, England, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bille","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust Department of Thoracic Surgery, , Great Maze Pond, London SE1 9RT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"key":"2024050605305279600_ref1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.athoracsur.2014.04.028","article-title":"A meta-analysis of surgical versus nonsurgical management of recurrent thymoma","volume":"98","author":"Hamaji","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"2024050605305279600_ref2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/jso.20671","article-title":"Outcome of surgical treatment for recurrent thymic epithelial tumors with reference to world health organization histologic classification system","volume":"95","author":"Okumura","year":"2007","journal-title":"J Surg Oncol"},{"key":"2024050605305279600_ref3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lungcan.2019.09.024","article-title":"Prognostic factors after treatment for iterative thymoma recurrences: a multicentric experience","volume":"138","author":"Chiappetta","year":"2019","journal-title":"Lung Cancer"},{"key":"2024050605305279600_ref4","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1097\/JTO.0000000000000370","article-title":"Long-term results after treatment for recurrent thymoma: a multicenter analysis","volume":"9","author":"Sandri","year":"2014","journal-title":"J Thorac Oncol"}],"container-title":["Journal of Surgical Case 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